The potential of Corona Charged Aerosol Detector for investigation of telmisartan: B-cyclodextrin inclusion complexes
Cyclodextrins (CDs) are widely used in pharmaceutical analysis due to its biodegradability and eco-friendly character. The particular structure of CDs, characterized by hydrophobic cavity, enables the formation of inclusion complexes with variety of organic compounds. As structures lacking chromopho...
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| Format: | Article |
| Language: | srp |
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Pharmaceutical Association of Serbia, Belgrade, Serbia
2019-01-01
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| Series: | Arhiv za farmaciju |
| Subjects: | |
| Online Access: | https://scindeks-clanci.ceon.rs/data/pdf/0004-1963/2019/0004-19631901001M.pdf |
| _version_ | 1818611000161599488 |
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| author | Maljurić Nevena Golubović Jelena Otašević Biljana Krmar Jovana Zečević Mira Protić Ana |
| author_facet | Maljurić Nevena Golubović Jelena Otašević Biljana Krmar Jovana Zečević Mira Protić Ana |
| author_sort | Maljurić Nevena |
| collection | DOAJ |
| description | Cyclodextrins (CDs) are widely used in pharmaceutical analysis due to its biodegradability and eco-friendly character. The particular structure of CDs, characterized by hydrophobic cavity, enables the formation of inclusion complexes with variety of organic compounds. As structures lacking chromophores, CDs could not be detected by Photodiode Array (PDA) detector and Corona Charged Aerosol Detector (CAD) was introduced as the most appropriate detector for the formed complexes. The aim of the study was to investigate the degree of complexation between telmisartan, used as a model substance, and b-CD. Moreover, the effect of different b-CD concentrations (5-15 mM) and pH of the aqueous part of mobile phase (3-7) on the degree of complexation was also assessed. The intensity of the formed complex appeared to be the highest when 15 mM b-CD was used for the complexation. Also, it was noticed that the increase in peak areas with an increasing b-CD concentration was more evident at pH 7 in comparison with the same trend at lower pH values. The reproducibility of the measurement was confirmed by low relative standard deviation (RSD) of peak areas within five measurements. These findings support the use of HPLC-CAD methods for studying the process of inclusion complexes formation. |
| first_indexed | 2024-12-16T15:23:22Z |
| format | Article |
| id | doaj.art-2f0bef2d25c341fc9ada9aaf3e9e52c9 |
| institution | Directory Open Access Journal |
| issn | 0004-1963 2217-8767 |
| language | srp |
| last_indexed | 2024-12-16T15:23:22Z |
| publishDate | 2019-01-01 |
| publisher | Pharmaceutical Association of Serbia, Belgrade, Serbia |
| record_format | Article |
| series | Arhiv za farmaciju |
| spelling | doaj.art-2f0bef2d25c341fc9ada9aaf3e9e52c92022-12-21T22:26:33ZsrpPharmaceutical Association of Serbia, Belgrade, SerbiaArhiv za farmaciju0004-19632217-87672019-01-0169111410.5937/arhfarm1901001M0004-19631901001MThe potential of Corona Charged Aerosol Detector for investigation of telmisartan: B-cyclodextrin inclusion complexesMaljurić Nevena0Golubović Jelena1https://orcid.org/0000-0003-4578-6804Otašević Biljana2https://orcid.org/0000-0002-4747-927XKrmar Jovana3https://orcid.org/0000-0002-5469-9633Zečević Mira4https://orcid.org/0000-0003-1531-2501Protić Ana5https://orcid.org/0000-0002-6304-1913University of Belgrade, Faculty of Pharmacy, Department of Drug Analysis, Belgrade, SerbiaUniversity of Belgrade, Faculty of Pharmacy, Department of Drug Analysis, Belgrade, SerbiaUniversity of Belgrade, Faculty of Pharmacy, Department of Drug Analysis, Belgrade, SerbiaUniversity of Belgrade, Faculty of Pharmacy, Department of Drug Analysis, Belgrade, SerbiaUniversity of Belgrade, Faculty of Pharmacy, Department of Drug Analysis, Belgrade, SerbiaUniversity of Belgrade, Faculty of Pharmacy, Department of Drug Analysis, Belgrade, SerbiaCyclodextrins (CDs) are widely used in pharmaceutical analysis due to its biodegradability and eco-friendly character. The particular structure of CDs, characterized by hydrophobic cavity, enables the formation of inclusion complexes with variety of organic compounds. As structures lacking chromophores, CDs could not be detected by Photodiode Array (PDA) detector and Corona Charged Aerosol Detector (CAD) was introduced as the most appropriate detector for the formed complexes. The aim of the study was to investigate the degree of complexation between telmisartan, used as a model substance, and b-CD. Moreover, the effect of different b-CD concentrations (5-15 mM) and pH of the aqueous part of mobile phase (3-7) on the degree of complexation was also assessed. The intensity of the formed complex appeared to be the highest when 15 mM b-CD was used for the complexation. Also, it was noticed that the increase in peak areas with an increasing b-CD concentration was more evident at pH 7 in comparison with the same trend at lower pH values. The reproducibility of the measurement was confirmed by low relative standard deviation (RSD) of peak areas within five measurements. These findings support the use of HPLC-CAD methods for studying the process of inclusion complexes formation.https://scindeks-clanci.ceon.rs/data/pdf/0004-1963/2019/0004-19631901001M.pdfb-cyclodextrininclusion complexcorona charged aerosol detectortelmisartan |
| spellingShingle | Maljurić Nevena Golubović Jelena Otašević Biljana Krmar Jovana Zečević Mira Protić Ana The potential of Corona Charged Aerosol Detector for investigation of telmisartan: B-cyclodextrin inclusion complexes Arhiv za farmaciju b-cyclodextrin inclusion complex corona charged aerosol detector telmisartan |
| title | The potential of Corona Charged Aerosol Detector for investigation of telmisartan: B-cyclodextrin inclusion complexes |
| title_full | The potential of Corona Charged Aerosol Detector for investigation of telmisartan: B-cyclodextrin inclusion complexes |
| title_fullStr | The potential of Corona Charged Aerosol Detector for investigation of telmisartan: B-cyclodextrin inclusion complexes |
| title_full_unstemmed | The potential of Corona Charged Aerosol Detector for investigation of telmisartan: B-cyclodextrin inclusion complexes |
| title_short | The potential of Corona Charged Aerosol Detector for investigation of telmisartan: B-cyclodextrin inclusion complexes |
| title_sort | potential of corona charged aerosol detector for investigation of telmisartan b cyclodextrin inclusion complexes |
| topic | b-cyclodextrin inclusion complex corona charged aerosol detector telmisartan |
| url | https://scindeks-clanci.ceon.rs/data/pdf/0004-1963/2019/0004-19631901001M.pdf |
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