Bioinformatic Description of Immunotherapy Targets for Pediatric T-Cell Leukemia and the Impact of Normal Gene Sets Used for Comparison

Bioinformatic Description of Immunotherapy Targets for Pediatric T-Cell Leukemia and the Impact of Normal Gene Sets Used for Comparison

Pediatric lymphoid leukemia has the highest cure rate of all pediatric malignancies, yet due to its prevalence, still accounts for the majority of childhood cancer deaths and requires long-term highly toxic therapy. The ability to target B-cell ALL with immunoglobulin-like binders, whether anti-CD...

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Bibliographic Details
Main Authors: Rimas J Orentas, Jessica eNordlund, Jianbin eHe, Sivasish eSindiri, Crystal eMackall, Terry J Fry, Javed eKhan
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-06-01
Series:Frontiers in Oncology
Subjects:
Immunotherapy
Leukemia
bioinformatics
Adoptive immunotherapy
Antibody therapy
chimeric antigen receptors
Online Access:http://journal.frontiersin.org/Journal/10.3389/fonc.2014.00134/full

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