Current practice and novel approaches in organ preservation
Organ transplantation remains the only treatment option for patients with end-stage organ failure. The last decade has seen a flurry of activity in improving organ preservation technologies, which promise to increase utilization in a dramatic fashion. They also bring the promise of extending the pre...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-06-01
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| Series: | Frontiers in Transplantation |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/frtra.2023.1156845/full |
| _version_ | 1797809005380239360 |
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| author | Ozge Sila Ozgur Ozge Sila Ozgur Bat-Erdene Namsrai Timothy L. Pruett John C. Bischof Mehmet Toner Mehmet Toner Erik B. Finger Korkut Uygun Korkut Uygun |
| author_facet | Ozge Sila Ozgur Ozge Sila Ozgur Bat-Erdene Namsrai Timothy L. Pruett John C. Bischof Mehmet Toner Mehmet Toner Erik B. Finger Korkut Uygun Korkut Uygun |
| author_sort | Ozge Sila Ozgur |
| collection | DOAJ |
| description | Organ transplantation remains the only treatment option for patients with end-stage organ failure. The last decade has seen a flurry of activity in improving organ preservation technologies, which promise to increase utilization in a dramatic fashion. They also bring the promise of extending the preservation duration significantly, which opens the doors to sharing organs across local and international boundaries and transforms the field. In this work, we review the recent literature on machine perfusion of livers across various protocols in development and clinical use, in the context of extending the preservation duration. We then review the next generation of technologies that have the potential to further extend the limits and open the door to banking organs, including supercooling, partial freezing, and nanowarming, and outline the opportunities arising in the field for researchers in the short and long term. |
| first_indexed | 2024-03-13T06:47:06Z |
| format | Article |
| id | doaj.art-2f0d038007404cf3bf01e1d1ca8710ac |
| institution | Directory Open Access Journal |
| issn | 2813-2440 |
| language | English |
| last_indexed | 2024-03-13T06:47:06Z |
| publishDate | 2023-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Transplantation |
| spelling | doaj.art-2f0d038007404cf3bf01e1d1ca8710ac2023-06-08T05:26:29ZengFrontiers Media S.A.Frontiers in Transplantation2813-24402023-06-01210.3389/frtra.2023.11568451156845Current practice and novel approaches in organ preservationOzge Sila Ozgur0Ozge Sila Ozgur1Bat-Erdene Namsrai2Timothy L. Pruett3John C. Bischof4Mehmet Toner5Mehmet Toner6Erik B. Finger7Korkut Uygun8Korkut Uygun9Department of Surgery, Center for Engineering in Medicine and Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United StatesResearch Department, Shriners Children’s Boston, Boston, MA, United StatesDepartment of Surgery, University of Minnesota, Minneapolis, MN, United StatesDepartment of Surgery, University of Minnesota, Minneapolis, MN, United StatesDepartments of Mechanical and Biomedical Engineering, University of Minnesota, Minneapolis, MN, United StatesDepartment of Surgery, Center for Engineering in Medicine and Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United StatesResearch Department, Shriners Children’s Boston, Boston, MA, United StatesDepartment of Surgery, University of Minnesota, Minneapolis, MN, United StatesDepartment of Surgery, Center for Engineering in Medicine and Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United StatesResearch Department, Shriners Children’s Boston, Boston, MA, United StatesOrgan transplantation remains the only treatment option for patients with end-stage organ failure. The last decade has seen a flurry of activity in improving organ preservation technologies, which promise to increase utilization in a dramatic fashion. They also bring the promise of extending the preservation duration significantly, which opens the doors to sharing organs across local and international boundaries and transforms the field. In this work, we review the recent literature on machine perfusion of livers across various protocols in development and clinical use, in the context of extending the preservation duration. We then review the next generation of technologies that have the potential to further extend the limits and open the door to banking organs, including supercooling, partial freezing, and nanowarming, and outline the opportunities arising in the field for researchers in the short and long term.https://www.frontiersin.org/articles/10.3389/frtra.2023.1156845/fullorgan transplantationliver preservationmachine perfusionsubzero preservationnanowarmingsupercooling |
| spellingShingle | Ozge Sila Ozgur Ozge Sila Ozgur Bat-Erdene Namsrai Timothy L. Pruett John C. Bischof Mehmet Toner Mehmet Toner Erik B. Finger Korkut Uygun Korkut Uygun Current practice and novel approaches in organ preservation Frontiers in Transplantation organ transplantation liver preservation machine perfusion subzero preservation nanowarming supercooling |
| title | Current practice and novel approaches in organ preservation |
| title_full | Current practice and novel approaches in organ preservation |
| title_fullStr | Current practice and novel approaches in organ preservation |
| title_full_unstemmed | Current practice and novel approaches in organ preservation |
| title_short | Current practice and novel approaches in organ preservation |
| title_sort | current practice and novel approaches in organ preservation |
| topic | organ transplantation liver preservation machine perfusion subzero preservation nanowarming supercooling |
| url | https://www.frontiersin.org/articles/10.3389/frtra.2023.1156845/full |
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