Pharmacological target and the biological mechanism of gallic acid for anticataract effect: A network analysis
Background: This study aimed to identify the pharmacological targets and mechanisms of action of the traditional Indian plant, Saraca asoca bioactive, gallic acid, in the treatment of cataract using bioinformatics tools i.e., network pharmacology. Material/Methods: Targets of cataract were obtained...
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| Format: | Article |
| Language: | English |
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Elsevier
2022-05-01
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| Series: | Phytomedicine Plus |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2667031322000446 |
| _version_ | 1818243955654918144 |
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| author | Mohd Riyaz Beg Adeeba Laeeq Sadhana Sathaye |
| author_facet | Mohd Riyaz Beg Adeeba Laeeq Sadhana Sathaye |
| author_sort | Mohd Riyaz Beg |
| collection | DOAJ |
| description | Background: This study aimed to identify the pharmacological targets and mechanisms of action of the traditional Indian plant, Saraca asoca bioactive, gallic acid, in the treatment of cataract using bioinformatics tools i.e., network pharmacology. Material/Methods: Targets of cataract were obtained by using DisGeNET gene discovery web-based database. The herbal ingredients target (HIT), the SuperPred, and the SwissTargetPrediction database were used for compound target prediction i.e., targets of gallic acid. Pathophysiological and therapeutic targets were imported to the STRING database, and the Cytoscape network integration software was used to construct component-target and disease-target interaction networks as a part of protein-protein interaction (PPI). Core targets were identified by network topological parameters and were further tested to identify the biological process and the signaling pathways by using functional enrichment analysis tool, FunRich. Results: Key targets genes for gallic acid in the treatment of patients with cataract were identified, including indoleamine-2,3-dioxygenase-1 (IDO1), serum albumin (ALB), estrogen receptor (ESR1), prostaglandin G/H synthase-2 (PTGS2), epidermal growth factor receptor (EGFR), plasminogen activator inhibitor-1 (SERPINE1), aromatase (CYP19A1), neutrophil elastase (ELANE), and catechol-O-methyltransferase (COMT), apoptosis regulator (BCL2), carbonic anhydrase-4 (CA4), tyrosine-protein kinase receptor UFO (AXL), tyrosinase (TYR), kallikrein-7 (KLK7), and serine/threonine-protein kinase (NEK2). The signaling pathways of core targets mainly involved signaling events mediated by BMP receptors, integrins, proteoglycan syndecan, glypican, TRAIL, S1P (sphingosine-1-phosphate), LKB1, endothelins, VEGF, VEGFR, estrogen receptors, INF-γ, IL-5, mTOR, biological oxidation, kynurenines formation, TGF-β, etc. Conclusion: Pharmacological network analysis was used to identify the gene targets and mechanisms of gallic acid for the treatment of patient with cataract. |
| first_indexed | 2024-12-12T14:09:21Z |
| format | Article |
| id | doaj.art-2f0e66fe7e2e4029ab011da5de219355 |
| institution | Directory Open Access Journal |
| issn | 2667-0313 |
| language | English |
| last_indexed | 2024-12-12T14:09:21Z |
| publishDate | 2022-05-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Phytomedicine Plus |
| spelling | doaj.art-2f0e66fe7e2e4029ab011da5de2193552022-12-22T00:22:07ZengElsevierPhytomedicine Plus2667-03132022-05-0122100258Pharmacological target and the biological mechanism of gallic acid for anticataract effect: A network analysisMohd Riyaz Beg0Adeeba Laeeq1Sadhana Sathaye2Department of Pharmaceutical Sciences and Technology, Institute of Chemical Technology, Mumbai 400019, Maharashtra, India; Corresponding author.Department of Pharmacology, School of Pharmaceutical Education and Research, Jamia Hamdard, New Delhi, IndiaDepartment of Pharmaceutical Sciences and Technology, Institute of Chemical Technology, Mumbai 400019, Maharashtra, IndiaBackground: This study aimed to identify the pharmacological targets and mechanisms of action of the traditional Indian plant, Saraca asoca bioactive, gallic acid, in the treatment of cataract using bioinformatics tools i.e., network pharmacology. Material/Methods: Targets of cataract were obtained by using DisGeNET gene discovery web-based database. The herbal ingredients target (HIT), the SuperPred, and the SwissTargetPrediction database were used for compound target prediction i.e., targets of gallic acid. Pathophysiological and therapeutic targets were imported to the STRING database, and the Cytoscape network integration software was used to construct component-target and disease-target interaction networks as a part of protein-protein interaction (PPI). Core targets were identified by network topological parameters and were further tested to identify the biological process and the signaling pathways by using functional enrichment analysis tool, FunRich. Results: Key targets genes for gallic acid in the treatment of patients with cataract were identified, including indoleamine-2,3-dioxygenase-1 (IDO1), serum albumin (ALB), estrogen receptor (ESR1), prostaglandin G/H synthase-2 (PTGS2), epidermal growth factor receptor (EGFR), plasminogen activator inhibitor-1 (SERPINE1), aromatase (CYP19A1), neutrophil elastase (ELANE), and catechol-O-methyltransferase (COMT), apoptosis regulator (BCL2), carbonic anhydrase-4 (CA4), tyrosine-protein kinase receptor UFO (AXL), tyrosinase (TYR), kallikrein-7 (KLK7), and serine/threonine-protein kinase (NEK2). The signaling pathways of core targets mainly involved signaling events mediated by BMP receptors, integrins, proteoglycan syndecan, glypican, TRAIL, S1P (sphingosine-1-phosphate), LKB1, endothelins, VEGF, VEGFR, estrogen receptors, INF-γ, IL-5, mTOR, biological oxidation, kynurenines formation, TGF-β, etc. Conclusion: Pharmacological network analysis was used to identify the gene targets and mechanisms of gallic acid for the treatment of patient with cataract.http://www.sciencedirect.com/science/article/pii/S2667031322000446Gallic acidNetwork pharmacologyCataractSaraca asocaProtein-protein interactionsOcular pharmacology |
| spellingShingle | Mohd Riyaz Beg Adeeba Laeeq Sadhana Sathaye Pharmacological target and the biological mechanism of gallic acid for anticataract effect: A network analysis Phytomedicine Plus Gallic acid Network pharmacology Cataract Saraca asoca Protein-protein interactions Ocular pharmacology |
| title | Pharmacological target and the biological mechanism of gallic acid for anticataract effect: A network analysis |
| title_full | Pharmacological target and the biological mechanism of gallic acid for anticataract effect: A network analysis |
| title_fullStr | Pharmacological target and the biological mechanism of gallic acid for anticataract effect: A network analysis |
| title_full_unstemmed | Pharmacological target and the biological mechanism of gallic acid for anticataract effect: A network analysis |
| title_short | Pharmacological target and the biological mechanism of gallic acid for anticataract effect: A network analysis |
| title_sort | pharmacological target and the biological mechanism of gallic acid for anticataract effect a network analysis |
| topic | Gallic acid Network pharmacology Cataract Saraca asoca Protein-protein interactions Ocular pharmacology |
| url | http://www.sciencedirect.com/science/article/pii/S2667031322000446 |
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