The diagnostic accuracy of intraoperative differentiation and delineation techniques in brain tumours
Abstract Brain tumour identification and delineation in a timeframe of seconds would significantly guide and support surgical decisions. Here, treatment is often complicated by the infiltration of gliomas in the surrounding brain parenchyma. Accurate delineation of the invasive margins is essential...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Springer
2022-11-01
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| Series: | Discover Oncology |
| Subjects: | |
| Online Access: | https://doi.org/10.1007/s12672-022-00585-z |
| _version_ | 1797988393106276352 |
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| author | Laura Van Hese Steven De Vleeschouwer Tom Theys Steffen Rex Ron M. A. Heeren Eva Cuypers |
| author_facet | Laura Van Hese Steven De Vleeschouwer Tom Theys Steffen Rex Ron M. A. Heeren Eva Cuypers |
| author_sort | Laura Van Hese |
| collection | DOAJ |
| description | Abstract Brain tumour identification and delineation in a timeframe of seconds would significantly guide and support surgical decisions. Here, treatment is often complicated by the infiltration of gliomas in the surrounding brain parenchyma. Accurate delineation of the invasive margins is essential to increase the extent of resection and to avoid postoperative neurological deficits. Currently, histopathological annotation of brain biopsies and genetic phenotyping still define the first line treatment, where results become only available after surgery. Furthermore, adjuvant techniques to improve intraoperative visualisation of the tumour tissue have been developed and validated. In this review, we focused on the sensitivity and specificity of conventional techniques to characterise the tumour type and margin, specifically fluorescent-guided surgery, neuronavigation and intraoperative imaging as well as on more experimental techniques such as mass spectrometry-based diagnostics, Raman spectrometry and hyperspectral imaging. Based on our findings, all investigated methods had their advantages and limitations, guiding researchers towards the combined use of intraoperative imaging techniques. This can lead to an improved outcome in terms of extent of tumour resection and progression free survival while preserving neurological outcome of the patients. |
| first_indexed | 2024-04-11T08:02:25Z |
| format | Article |
| id | doaj.art-2f113aea6ff14027bd4b754a7e2de766 |
| institution | Directory Open Access Journal |
| issn | 2730-6011 |
| language | English |
| last_indexed | 2024-04-11T08:02:25Z |
| publishDate | 2022-11-01 |
| publisher | Springer |
| record_format | Article |
| series | Discover Oncology |
| spelling | doaj.art-2f113aea6ff14027bd4b754a7e2de7662022-12-22T04:35:39ZengSpringerDiscover Oncology2730-60112022-11-0113111410.1007/s12672-022-00585-zThe diagnostic accuracy of intraoperative differentiation and delineation techniques in brain tumoursLaura Van Hese0Steven De Vleeschouwer1Tom Theys2Steffen Rex3Ron M. A. Heeren4Eva Cuypers5Division of Mass Spectrometry Imaging, Maastricht MultiModal Molecular Imaging (M4I) Institute, Maastricht UniversityNeurosurgery Department, University Hospitals LeuvenNeurosurgery Department, University Hospitals LeuvenDepartment of Anaesthesiology, University Hospitals LeuvenDivision of Mass Spectrometry Imaging, Maastricht MultiModal Molecular Imaging (M4I) Institute, Maastricht UniversityDivision of Mass Spectrometry Imaging, Maastricht MultiModal Molecular Imaging (M4I) Institute, Maastricht UniversityAbstract Brain tumour identification and delineation in a timeframe of seconds would significantly guide and support surgical decisions. Here, treatment is often complicated by the infiltration of gliomas in the surrounding brain parenchyma. Accurate delineation of the invasive margins is essential to increase the extent of resection and to avoid postoperative neurological deficits. Currently, histopathological annotation of brain biopsies and genetic phenotyping still define the first line treatment, where results become only available after surgery. Furthermore, adjuvant techniques to improve intraoperative visualisation of the tumour tissue have been developed and validated. In this review, we focused on the sensitivity and specificity of conventional techniques to characterise the tumour type and margin, specifically fluorescent-guided surgery, neuronavigation and intraoperative imaging as well as on more experimental techniques such as mass spectrometry-based diagnostics, Raman spectrometry and hyperspectral imaging. Based on our findings, all investigated methods had their advantages and limitations, guiding researchers towards the combined use of intraoperative imaging techniques. This can lead to an improved outcome in terms of extent of tumour resection and progression free survival while preserving neurological outcome of the patients.https://doi.org/10.1007/s12672-022-00585-zBrain tumourIntraoperative characterisationTumour margin delineationLiterature review |
| spellingShingle | Laura Van Hese Steven De Vleeschouwer Tom Theys Steffen Rex Ron M. A. Heeren Eva Cuypers The diagnostic accuracy of intraoperative differentiation and delineation techniques in brain tumours Discover Oncology Brain tumour Intraoperative characterisation Tumour margin delineation Literature review |
| title | The diagnostic accuracy of intraoperative differentiation and delineation techniques in brain tumours |
| title_full | The diagnostic accuracy of intraoperative differentiation and delineation techniques in brain tumours |
| title_fullStr | The diagnostic accuracy of intraoperative differentiation and delineation techniques in brain tumours |
| title_full_unstemmed | The diagnostic accuracy of intraoperative differentiation and delineation techniques in brain tumours |
| title_short | The diagnostic accuracy of intraoperative differentiation and delineation techniques in brain tumours |
| title_sort | diagnostic accuracy of intraoperative differentiation and delineation techniques in brain tumours |
| topic | Brain tumour Intraoperative characterisation Tumour margin delineation Literature review |
| url | https://doi.org/10.1007/s12672-022-00585-z |
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