Protein profile of different cellular fractions from Mycobacterium tuberculosis strains after exposure to isoniazid
Different biochemical studies looking for the effect of INH on the physiology of Mycobacterium tuberculosis (Mtb) have been conducted. Here, we present a detailed analysis, looking at the protein variation in the Mtb cell due to exposure of sub-inhibitory concentrations of INH, evaluating three diff...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2019-06-01
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| Series: | Data in Brief |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S235234091930304X |
| _version_ | 1818260755115409408 |
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| author | Luisa María Nieto Ramirez Carolina Mehaffy Karen M. Dobos |
| author_facet | Luisa María Nieto Ramirez Carolina Mehaffy Karen M. Dobos |
| author_sort | Luisa María Nieto Ramirez |
| collection | DOAJ |
| description | Different biochemical studies looking for the effect of INH on the physiology of Mycobacterium tuberculosis (Mtb) have been conducted. Here, we present a detailed analysis, looking at the protein variation in the Mtb cell due to exposure of sub-inhibitory concentrations of INH, evaluating three different variables: cellular fraction, genetic lineage, and INH phenotypic profile. Mass spectrometry analysis demonstrated that the most significantly affected cellular fraction was the membrane and the INH resistant strains showed the highest number of proteins altered when they were exposed to INH. Raw data are available via ProteomeXchange with identifier PXD007588. |
| first_indexed | 2024-12-12T18:36:22Z |
| format | Article |
| id | doaj.art-2f138d82a79848548b66a433ea656c82 |
| institution | Directory Open Access Journal |
| issn | 2352-3409 |
| language | English |
| last_indexed | 2024-12-12T18:36:22Z |
| publishDate | 2019-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Data in Brief |
| spelling | doaj.art-2f138d82a79848548b66a433ea656c822022-12-22T00:15:46ZengElsevierData in Brief2352-34092019-06-0124Protein profile of different cellular fractions from Mycobacterium tuberculosis strains after exposure to isoniazidLuisa María Nieto Ramirez0Carolina Mehaffy1Karen M. Dobos2Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO, USA; Universidad Santiago de Cali, Cali, ColombiaDepartment of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO, USADepartment of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO, USA; Corresponding author.Different biochemical studies looking for the effect of INH on the physiology of Mycobacterium tuberculosis (Mtb) have been conducted. Here, we present a detailed analysis, looking at the protein variation in the Mtb cell due to exposure of sub-inhibitory concentrations of INH, evaluating three different variables: cellular fraction, genetic lineage, and INH phenotypic profile. Mass spectrometry analysis demonstrated that the most significantly affected cellular fraction was the membrane and the INH resistant strains showed the highest number of proteins altered when they were exposed to INH. Raw data are available via ProteomeXchange with identifier PXD007588.http://www.sciencedirect.com/science/article/pii/S235234091930304X |
| spellingShingle | Luisa María Nieto Ramirez Carolina Mehaffy Karen M. Dobos Protein profile of different cellular fractions from Mycobacterium tuberculosis strains after exposure to isoniazid Data in Brief |
| title | Protein profile of different cellular fractions from Mycobacterium tuberculosis strains after exposure to isoniazid |
| title_full | Protein profile of different cellular fractions from Mycobacterium tuberculosis strains after exposure to isoniazid |
| title_fullStr | Protein profile of different cellular fractions from Mycobacterium tuberculosis strains after exposure to isoniazid |
| title_full_unstemmed | Protein profile of different cellular fractions from Mycobacterium tuberculosis strains after exposure to isoniazid |
| title_short | Protein profile of different cellular fractions from Mycobacterium tuberculosis strains after exposure to isoniazid |
| title_sort | protein profile of different cellular fractions from mycobacterium tuberculosis strains after exposure to isoniazid |
| url | http://www.sciencedirect.com/science/article/pii/S235234091930304X |
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