Lycorine transfersomes modified with cell-penetrating peptides for topical treatment of cutaneous squamous cell carcinoma
Abstract Background Topical anticancer drugs offer a potential therapeutic modality with high compliance for treating cutaneous squamous cell carcinoma (cSCC). However, the existing topical treatments for cSCC are associated with limited penetrating ability to achieve the desired outcome. Therefore,...
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| Format: | Article |
| Language: | English |
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BMC
2023-04-01
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| Series: | Journal of Nanobiotechnology |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12951-023-01877-4 |
| _version_ | 1797836267556175872 |
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| author | Ying Li Zongguang Tai Jinyuan Ma Fengze Miao Rujuan Xin Cuie Shen Min Shen Quangang Zhu Zhongjian Chen |
| author_facet | Ying Li Zongguang Tai Jinyuan Ma Fengze Miao Rujuan Xin Cuie Shen Min Shen Quangang Zhu Zhongjian Chen |
| author_sort | Ying Li |
| collection | DOAJ |
| description | Abstract Background Topical anticancer drugs offer a potential therapeutic modality with high compliance for treating cutaneous squamous cell carcinoma (cSCC). However, the existing topical treatments for cSCC are associated with limited penetrating ability to achieve the desired outcome. Therefore, there remains an urgent requirement to develop drugs with efficient anticancer activity suitable for treating cSCC and to overcome the skin physiological barrier to improve the efficiency of drug delivery to the tumor. Results We introduced lycorine (LR) into the topical treatment for cSCC and developed a cell-penetrating peptide (CPP)-modified cationic transfersome gel loaded with lycorine-oleic acid ionic complex (LR-OA) (LR@DTFs-CPP Gel) and investigated its topical therapeutic effects on cSCC. The anti-cSCC effects of LR and skin penetration of LR-OA transfersomes were confirmed. Simultaneously, cationic lipids and modification of R5H3 peptide of the transfersomes further enhanced the permeability of the skin and tumor as well as the effective delivery of LR to tumor cells. Conclusions Topical treatment of cSCC-xenografted nude mice with LR@DTFs-CPP Gel showed effective anticancer properties with high safety. This novel formulation provides novel insights into the treatment and pathogenesis of cSCC. |
| first_indexed | 2024-04-09T15:05:58Z |
| format | Article |
| id | doaj.art-2f1456dcda82457588f083fe6622f9cf |
| institution | Directory Open Access Journal |
| issn | 1477-3155 |
| language | English |
| last_indexed | 2024-04-09T15:05:58Z |
| publishDate | 2023-04-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Nanobiotechnology |
| spelling | doaj.art-2f1456dcda82457588f083fe6622f9cf2023-04-30T11:27:07ZengBMCJournal of Nanobiotechnology1477-31552023-04-0121111810.1186/s12951-023-01877-4Lycorine transfersomes modified with cell-penetrating peptides for topical treatment of cutaneous squamous cell carcinomaYing Li0Zongguang Tai1Jinyuan Ma2Fengze Miao3Rujuan Xin4Cuie Shen5Min Shen6Quangang Zhu7Zhongjian Chen8Shanghai Skin Disease Hospital, School of Medicine, Tongji UniversityShanghai Skin Disease Hospital, School of Medicine, Tongji UniversityShanghai Skin Disease Hospital, School of Medicine, Tongji UniversityShanghai Skin Disease Hospital, School of Medicine, Tongji UniversityShanghai Skin Disease Hospital, School of Medicine, Tongji UniversityShanghai Skin Disease Hospital, School of Medicine, Tongji UniversityShanghai Skin Disease Hospital, School of Medicine, Tongji UniversityShanghai Skin Disease Hospital, School of Medicine, Tongji UniversityShanghai Skin Disease Hospital, School of Medicine, Tongji UniversityAbstract Background Topical anticancer drugs offer a potential therapeutic modality with high compliance for treating cutaneous squamous cell carcinoma (cSCC). However, the existing topical treatments for cSCC are associated with limited penetrating ability to achieve the desired outcome. Therefore, there remains an urgent requirement to develop drugs with efficient anticancer activity suitable for treating cSCC and to overcome the skin physiological barrier to improve the efficiency of drug delivery to the tumor. Results We introduced lycorine (LR) into the topical treatment for cSCC and developed a cell-penetrating peptide (CPP)-modified cationic transfersome gel loaded with lycorine-oleic acid ionic complex (LR-OA) (LR@DTFs-CPP Gel) and investigated its topical therapeutic effects on cSCC. The anti-cSCC effects of LR and skin penetration of LR-OA transfersomes were confirmed. Simultaneously, cationic lipids and modification of R5H3 peptide of the transfersomes further enhanced the permeability of the skin and tumor as well as the effective delivery of LR to tumor cells. Conclusions Topical treatment of cSCC-xenografted nude mice with LR@DTFs-CPP Gel showed effective anticancer properties with high safety. This novel formulation provides novel insights into the treatment and pathogenesis of cSCC.https://doi.org/10.1186/s12951-023-01877-4LycorineCutaneous squamous cell carcinomaTopical treatmentTransfersomeCell-penetrating peptide |
| spellingShingle | Ying Li Zongguang Tai Jinyuan Ma Fengze Miao Rujuan Xin Cuie Shen Min Shen Quangang Zhu Zhongjian Chen Lycorine transfersomes modified with cell-penetrating peptides for topical treatment of cutaneous squamous cell carcinoma Journal of Nanobiotechnology Lycorine Cutaneous squamous cell carcinoma Topical treatment Transfersome Cell-penetrating peptide |
| title | Lycorine transfersomes modified with cell-penetrating peptides for topical treatment of cutaneous squamous cell carcinoma |
| title_full | Lycorine transfersomes modified with cell-penetrating peptides for topical treatment of cutaneous squamous cell carcinoma |
| title_fullStr | Lycorine transfersomes modified with cell-penetrating peptides for topical treatment of cutaneous squamous cell carcinoma |
| title_full_unstemmed | Lycorine transfersomes modified with cell-penetrating peptides for topical treatment of cutaneous squamous cell carcinoma |
| title_short | Lycorine transfersomes modified with cell-penetrating peptides for topical treatment of cutaneous squamous cell carcinoma |
| title_sort | lycorine transfersomes modified with cell penetrating peptides for topical treatment of cutaneous squamous cell carcinoma |
| topic | Lycorine Cutaneous squamous cell carcinoma Topical treatment Transfersome Cell-penetrating peptide |
| url | https://doi.org/10.1186/s12951-023-01877-4 |
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