Established and advanced adjuvants in vaccines' formulation: Mineral adsorbents, nanoparticulate carriers and microneedle delivery systems
In the era of modern vaccinology, limited immunogenicity of the most commonly used antigens has enforced the use of various adjuvants in vaccine formulations to achieve desired immune response. Aluminum-containing adjuvants have been, historically, the most widely used mineral immunostimulants, gene...
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| Format: | Article |
| Language: | srp |
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Pharmaceutical Association of Serbia, Belgrade, Serbia
2019-01-01
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| Series: | Arhiv za farmaciju |
| Subjects: | |
| Online Access: | https://scindeks-clanci.ceon.rs/data/pdf/0004-1963/2019/0004-19631906420K.pdf |
| _version_ | 1818574290346311680 |
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| author | Krajišnik Danina Ilić Tanja Nikolić Ines Savić Snežana |
| author_facet | Krajišnik Danina Ilić Tanja Nikolić Ines Savić Snežana |
| author_sort | Krajišnik Danina |
| collection | DOAJ |
| description | In the era of modern vaccinology, limited immunogenicity of the most commonly used antigens has enforced the use of various adjuvants in vaccine formulations to achieve desired immune response. Aluminum-containing adjuvants have been, historically, the most widely used mineral immunostimulants, generally regarded as safe to use in human vaccines. The great academic progress in inorganic (nano)materials synthesis, structure control and functionalization design has led to a growing interest in innovative adjuvants such as clays, mesoporous silica nanoparticles, zinc oxide, iron oxide and iron hydroxide nanoparticles, etc. On the other hand, there has been an intention to use specific nanoparticulated antigen delivery systems, such as nanoemulsions, in order to protect antigens from premature proteolytic degradation and/or to improve antigen immunogenicity by facilitating antigen uptake and processing by antigen presenting cells. Simultaneously, numerous research efforts have been focused on the development of innovative technologies for antigen delivery into the skin (such as microneedles), with the aim to improve vaccine efficacy alongside with enhanced patient adherence, particularly in children population (noninvasive or minimally invasive administration). Therefore, this review deals with each of these approaches in more detail, with the special emphasis on examples of their use in vaccine formulations as well as on the factors influencing their efficacy and safety. |
| first_indexed | 2024-12-15T00:24:37Z |
| format | Article |
| id | doaj.art-2f162e38b1f54474b9ed8eba9b09ea74 |
| institution | Directory Open Access Journal |
| issn | 0004-1963 2217-8767 |
| language | srp |
| last_indexed | 2024-12-15T00:24:37Z |
| publishDate | 2019-01-01 |
| publisher | Pharmaceutical Association of Serbia, Belgrade, Serbia |
| record_format | Article |
| series | Arhiv za farmaciju |
| spelling | doaj.art-2f162e38b1f54474b9ed8eba9b09ea742022-12-21T22:42:11ZsrpPharmaceutical Association of Serbia, Belgrade, SerbiaArhiv za farmaciju0004-19632217-87672019-01-0169642045110.5937/arhfarm1906420K0004-19631906420KEstablished and advanced adjuvants in vaccines' formulation: Mineral adsorbents, nanoparticulate carriers and microneedle delivery systemsKrajišnik Danina0https://orcid.org/0000-0002-5525-0109Ilić Tanja1Nikolić Ines2Savić Snežana3https://orcid.org/0000-0002-6236-9730University of Belgrade, Faculty of Pharmacy, Department of Pharmaceutical Technology and Cosmetology, SerbiaUniversity of Belgrade, Faculty of Pharmacy, Department of Pharmaceutical Technology and Cosmetology, SerbiaUniversity of Belgrade, Faculty of Pharmacy, Department of Pharmaceutical Technology and Cosmetology, SerbiaUniversity of Belgrade, Faculty of Pharmacy, Department of Pharmaceutical Technology and Cosmetology, SerbiaIn the era of modern vaccinology, limited immunogenicity of the most commonly used antigens has enforced the use of various adjuvants in vaccine formulations to achieve desired immune response. Aluminum-containing adjuvants have been, historically, the most widely used mineral immunostimulants, generally regarded as safe to use in human vaccines. The great academic progress in inorganic (nano)materials synthesis, structure control and functionalization design has led to a growing interest in innovative adjuvants such as clays, mesoporous silica nanoparticles, zinc oxide, iron oxide and iron hydroxide nanoparticles, etc. On the other hand, there has been an intention to use specific nanoparticulated antigen delivery systems, such as nanoemulsions, in order to protect antigens from premature proteolytic degradation and/or to improve antigen immunogenicity by facilitating antigen uptake and processing by antigen presenting cells. Simultaneously, numerous research efforts have been focused on the development of innovative technologies for antigen delivery into the skin (such as microneedles), with the aim to improve vaccine efficacy alongside with enhanced patient adherence, particularly in children population (noninvasive or minimally invasive administration). Therefore, this review deals with each of these approaches in more detail, with the special emphasis on examples of their use in vaccine formulations as well as on the factors influencing their efficacy and safety.https://scindeks-clanci.ceon.rs/data/pdf/0004-1963/2019/0004-19631906420K.pdfvaccine formulationadjuvantsmineral adsorbentsnanoemulsionsmicroneedles |
| spellingShingle | Krajišnik Danina Ilić Tanja Nikolić Ines Savić Snežana Established and advanced adjuvants in vaccines' formulation: Mineral adsorbents, nanoparticulate carriers and microneedle delivery systems Arhiv za farmaciju vaccine formulation adjuvants mineral adsorbents nanoemulsions microneedles |
| title | Established and advanced adjuvants in vaccines' formulation: Mineral adsorbents, nanoparticulate carriers and microneedle delivery systems |
| title_full | Established and advanced adjuvants in vaccines' formulation: Mineral adsorbents, nanoparticulate carriers and microneedle delivery systems |
| title_fullStr | Established and advanced adjuvants in vaccines' formulation: Mineral adsorbents, nanoparticulate carriers and microneedle delivery systems |
| title_full_unstemmed | Established and advanced adjuvants in vaccines' formulation: Mineral adsorbents, nanoparticulate carriers and microneedle delivery systems |
| title_short | Established and advanced adjuvants in vaccines' formulation: Mineral adsorbents, nanoparticulate carriers and microneedle delivery systems |
| title_sort | established and advanced adjuvants in vaccines formulation mineral adsorbents nanoparticulate carriers and microneedle delivery systems |
| topic | vaccine formulation adjuvants mineral adsorbents nanoemulsions microneedles |
| url | https://scindeks-clanci.ceon.rs/data/pdf/0004-1963/2019/0004-19631906420K.pdf |
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