Silver nanoparticles synthesized from the seaweed Sargassum polycystum and screening for their biological potential
Abstract World-wide antimicrobial resistant is biggest threat in global health. It requires the urgent need of multisectoral action for the scientific community to achieve the sustainable development Goals. Due to their antimicrobial properties, silver nanoparticles are potential activates to pathog...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2022-08-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-022-18379-2 |
| _version_ | 1811274927857205248 |
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| author | Rajasekar Thiurunavukkarau Sabarika Shanmugam Kumaran Subramanian Priyadarshini Pandi Gangatharan Muralitharan Maryshamya Arokiarajan Karthika Kasinathan Anbarasu Sivaraj Revathy Kalyanasundaram Suliman Yousef AlOmar Velmurugan Shanmugam |
| author_facet | Rajasekar Thiurunavukkarau Sabarika Shanmugam Kumaran Subramanian Priyadarshini Pandi Gangatharan Muralitharan Maryshamya Arokiarajan Karthika Kasinathan Anbarasu Sivaraj Revathy Kalyanasundaram Suliman Yousef AlOmar Velmurugan Shanmugam |
| author_sort | Rajasekar Thiurunavukkarau |
| collection | DOAJ |
| description | Abstract World-wide antimicrobial resistant is biggest threat in global health. It requires the urgent need of multisectoral action for the scientific community to achieve the sustainable development Goals. Due to their antimicrobial properties, silver nanoparticles are potential activates to pathogens, which explains their potential for multiple applications in various fields. In the present studies, we evaluate the antimicrobial properties of a Sargassum polycystum algal extract, an unrivaled green synthetic method for producing -defined shaped seaweed silver nanoparticles. To confirm their structure and size, some characterization techniques are used, such as Absorption spectrophotometer (UV–VIS), Fourier transforms infrared spectroscopy (FTIR), Scanning electron Microscope (SEM), Transmission electron microscopy (TEM) and X-Ray diffraction (XRD). Evaluate the antibacterial and anti-mycobacterial activity using silver nanoparticles. The toxicity study of this silver nanoparticle has been done with the help of zebrafish larva. The biological nanoparticle having good antimicrobial activity against Staphylococcus aureus, Micrococcus luteus, Pseudomonas fluorescens and Candida albicans and also it shows potent activity against MTB H37Rv, SHRE sensitive MTB Rifampicin resistant MTB around 98%. Seaweed nanoparticles had lower toxicity for the survival of the fish larvae. In comparison, other dosages will arrest the cell cycle and leads to death. The present finding revealed that these seaweeds nanoparticles have potential anti-mycobacterial activity against pathogens at low concentrations. This makes them a potent source of antibacterial and anti-TB agents |
| first_indexed | 2024-04-12T23:27:56Z |
| format | Article |
| id | doaj.art-2f1677d5e74d471187535125b83665e9 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-04-12T23:27:56Z |
| publishDate | 2022-08-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-2f1677d5e74d471187535125b83665e92022-12-22T03:12:21ZengNature PortfolioScientific Reports2045-23222022-08-0112111110.1038/s41598-022-18379-2Silver nanoparticles synthesized from the seaweed Sargassum polycystum and screening for their biological potentialRajasekar Thiurunavukkarau0Sabarika Shanmugam1Kumaran Subramanian2Priyadarshini Pandi3Gangatharan Muralitharan4Maryshamya Arokiarajan5Karthika Kasinathan6Anbarasu Sivaraj7Revathy Kalyanasundaram8Suliman Yousef AlOmar9Velmurugan Shanmugam10Centre for Drug Discovery and Development, Col. Dr. Jeppiaar Research Park, Sathyabama Institute of Science and Technology Jeppiaar NagarDepartmentof Microbiology, Centre of Excellence in Life Sciences, Bharathidasan UniversityCentre for Drug Discovery and Development, Col. Dr. Jeppiaar Research Park, Sathyabama Institute of Science and Technology Jeppiaar NagarDepartment of Biotechnology, Mohamed Sathak College of Arts and ScienceDepartmentof Microbiology, Centre of Excellence in Life Sciences, Bharathidasan UniversityCentre for Drug Discovery and Development, Col. Dr. Jeppiaar Research Park, Sathyabama Institute of Science and Technology Jeppiaar NagarDepartmentof Microbiology, Centre of Excellence in Life Sciences, Bharathidasan UniversityCentre for Drug Discovery and Development, Col. Dr. Jeppiaar Research Park, Sathyabama Institute of Science and Technology Jeppiaar NagarCentre for Drug Discovery and Development, Col. Dr. Jeppiaar Research Park, Sathyabama Institute of Science and Technology Jeppiaar NagarDepartment of Zoology, College of Science, Kind Saud UniversityMadda Walabu UniversityAbstract World-wide antimicrobial resistant is biggest threat in global health. It requires the urgent need of multisectoral action for the scientific community to achieve the sustainable development Goals. Due to their antimicrobial properties, silver nanoparticles are potential activates to pathogens, which explains their potential for multiple applications in various fields. In the present studies, we evaluate the antimicrobial properties of a Sargassum polycystum algal extract, an unrivaled green synthetic method for producing -defined shaped seaweed silver nanoparticles. To confirm their structure and size, some characterization techniques are used, such as Absorption spectrophotometer (UV–VIS), Fourier transforms infrared spectroscopy (FTIR), Scanning electron Microscope (SEM), Transmission electron microscopy (TEM) and X-Ray diffraction (XRD). Evaluate the antibacterial and anti-mycobacterial activity using silver nanoparticles. The toxicity study of this silver nanoparticle has been done with the help of zebrafish larva. The biological nanoparticle having good antimicrobial activity against Staphylococcus aureus, Micrococcus luteus, Pseudomonas fluorescens and Candida albicans and also it shows potent activity against MTB H37Rv, SHRE sensitive MTB Rifampicin resistant MTB around 98%. Seaweed nanoparticles had lower toxicity for the survival of the fish larvae. In comparison, other dosages will arrest the cell cycle and leads to death. The present finding revealed that these seaweeds nanoparticles have potential anti-mycobacterial activity against pathogens at low concentrations. This makes them a potent source of antibacterial and anti-TB agentshttps://doi.org/10.1038/s41598-022-18379-2 |
| spellingShingle | Rajasekar Thiurunavukkarau Sabarika Shanmugam Kumaran Subramanian Priyadarshini Pandi Gangatharan Muralitharan Maryshamya Arokiarajan Karthika Kasinathan Anbarasu Sivaraj Revathy Kalyanasundaram Suliman Yousef AlOmar Velmurugan Shanmugam Silver nanoparticles synthesized from the seaweed Sargassum polycystum and screening for their biological potential Scientific Reports |
| title | Silver nanoparticles synthesized from the seaweed Sargassum polycystum and screening for their biological potential |
| title_full | Silver nanoparticles synthesized from the seaweed Sargassum polycystum and screening for their biological potential |
| title_fullStr | Silver nanoparticles synthesized from the seaweed Sargassum polycystum and screening for their biological potential |
| title_full_unstemmed | Silver nanoparticles synthesized from the seaweed Sargassum polycystum and screening for their biological potential |
| title_short | Silver nanoparticles synthesized from the seaweed Sargassum polycystum and screening for their biological potential |
| title_sort | silver nanoparticles synthesized from the seaweed sargassum polycystum and screening for their biological potential |
| url | https://doi.org/10.1038/s41598-022-18379-2 |
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