Adverse effects of air pollutant exposure on blood lipid levels in adults: A systematic review and meta-analysis
Background: Air pollution is a crucial public health issue, but evidence on its association with blood lipids is still limited and inconsistent. Objectives: To systematically review and explore associations between major air pollutants (PM2.5, PM10, SO2, NO2, and O3) and blood lipid levels in long-,...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Health/LWW
2020-01-01
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| Series: | Cardiology Plus |
| Subjects: | |
| Online Access: | http://www.cardiologyplus.org/article.asp?issn=2470-7511;year=2020;volume=5;issue=3;spage=118;epage=129;aulast=Zhang |
| _version_ | 1828217447865384960 |
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| author | Xin-Yu Zhang Si-Han Huang Hai-Yan Gong Xin-Yan Wang Ke-Yong Huang Xiang-Feng Lu Fang-Chao Liu |
| author_facet | Xin-Yu Zhang Si-Han Huang Hai-Yan Gong Xin-Yan Wang Ke-Yong Huang Xiang-Feng Lu Fang-Chao Liu |
| author_sort | Xin-Yu Zhang |
| collection | DOAJ |
| description | Background: Air pollution is a crucial public health issue, but evidence on its association with blood lipids is still limited and inconsistent. Objectives: To systematically review and explore associations between major air pollutants (PM2.5, PM10, SO2, NO2, and O3) and blood lipid levels in long-, middle-, and short-term exposure durations. Data Source: Databases of PubMed, Embase, and Web of Science were searched for eligible articles published until August 16, 2019. Study Eligibility Criteria: English articles were explored for associations between air pollutants and blood lipids among adults using quantitative measures. Methods: Random-effect models were used to synthesize the association, and I2 value was used to evaluate the degree of heterogeneity. Results: Of the 15 studies that met the inclusion criteria, 11, 7, and 4 records were used to evaluate long-, middle-, and short-term effects. Generally, air pollutants had adverse influence on blood lipid levels, and results were robust across sensitivity analyses. For example, PM2.5 was significantly associated with increased total cholesterol and low-density lipoprotein-cholesterol levels, with a percentage change of 4.53 (0.12, 8.93) and 5.36 (0.37, 10.35) per 10 μg/m3 increment, respectively, in long-term exposure. However, associations with NO2, SO2, and O3 were still insufficient. Moreover, prospective evidence was considerably inadequate. Limitation: We only pooled the association of air pollution with major blood lipids. We were unable to clarify the health effects of chemical components or susceptible population because of limited studies. Conclusions: Ambient air pollutants have detrimental effects on blood lipid levels. Further prospective evidence is highly warranted to demonstrate these associations. |
| first_indexed | 2024-04-12T15:48:23Z |
| format | Article |
| id | doaj.art-2f193f39c70b4c05b2551b16a4e23925 |
| institution | Directory Open Access Journal |
| issn | 2470-7511 2470-752X |
| language | English |
| last_indexed | 2024-04-12T15:48:23Z |
| publishDate | 2020-01-01 |
| publisher | Wolters Kluwer Health/LWW |
| record_format | Article |
| series | Cardiology Plus |
| spelling | doaj.art-2f193f39c70b4c05b2551b16a4e239252022-12-22T03:26:36ZengWolters Kluwer Health/LWWCardiology Plus2470-75112470-752X2020-01-015311812910.4103/cp.cp_18_20Adverse effects of air pollutant exposure on blood lipid levels in adults: A systematic review and meta-analysisXin-Yu ZhangSi-Han HuangHai-Yan GongXin-Yan WangKe-Yong HuangXiang-Feng LuFang-Chao LiuBackground: Air pollution is a crucial public health issue, but evidence on its association with blood lipids is still limited and inconsistent. Objectives: To systematically review and explore associations between major air pollutants (PM2.5, PM10, SO2, NO2, and O3) and blood lipid levels in long-, middle-, and short-term exposure durations. Data Source: Databases of PubMed, Embase, and Web of Science were searched for eligible articles published until August 16, 2019. Study Eligibility Criteria: English articles were explored for associations between air pollutants and blood lipids among adults using quantitative measures. Methods: Random-effect models were used to synthesize the association, and I2 value was used to evaluate the degree of heterogeneity. Results: Of the 15 studies that met the inclusion criteria, 11, 7, and 4 records were used to evaluate long-, middle-, and short-term effects. Generally, air pollutants had adverse influence on blood lipid levels, and results were robust across sensitivity analyses. For example, PM2.5 was significantly associated with increased total cholesterol and low-density lipoprotein-cholesterol levels, with a percentage change of 4.53 (0.12, 8.93) and 5.36 (0.37, 10.35) per 10 μg/m3 increment, respectively, in long-term exposure. However, associations with NO2, SO2, and O3 were still insufficient. Moreover, prospective evidence was considerably inadequate. Limitation: We only pooled the association of air pollution with major blood lipids. We were unable to clarify the health effects of chemical components or susceptible population because of limited studies. Conclusions: Ambient air pollutants have detrimental effects on blood lipid levels. Further prospective evidence is highly warranted to demonstrate these associations.http://www.cardiologyplus.org/article.asp?issn=2470-7511;year=2020;volume=5;issue=3;spage=118;epage=129;aulast=Zhangair pollutants; lipids; meta-analysis |
| spellingShingle | Xin-Yu Zhang Si-Han Huang Hai-Yan Gong Xin-Yan Wang Ke-Yong Huang Xiang-Feng Lu Fang-Chao Liu Adverse effects of air pollutant exposure on blood lipid levels in adults: A systematic review and meta-analysis Cardiology Plus air pollutants; lipids; meta-analysis |
| title | Adverse effects of air pollutant exposure on blood lipid levels in adults: A systematic review and meta-analysis |
| title_full | Adverse effects of air pollutant exposure on blood lipid levels in adults: A systematic review and meta-analysis |
| title_fullStr | Adverse effects of air pollutant exposure on blood lipid levels in adults: A systematic review and meta-analysis |
| title_full_unstemmed | Adverse effects of air pollutant exposure on blood lipid levels in adults: A systematic review and meta-analysis |
| title_short | Adverse effects of air pollutant exposure on blood lipid levels in adults: A systematic review and meta-analysis |
| title_sort | adverse effects of air pollutant exposure on blood lipid levels in adults a systematic review and meta analysis |
| topic | air pollutants; lipids; meta-analysis |
| url | http://www.cardiologyplus.org/article.asp?issn=2470-7511;year=2020;volume=5;issue=3;spage=118;epage=129;aulast=Zhang |
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