NG2 glial cells integrate synaptic input in global and dendritic calcium signals
Synaptic signaling to NG2-expressing oligodendrocyte precursor cells (NG2 cells) could be key to rendering myelination of axons dependent on neuronal activity, but it has remained unclear whether NG2 glial cells integrate and respond to synaptic input. Here we show that NG2 cells perform linear inte...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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eLife Sciences Publications Ltd
2016-09-01
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| Series: | eLife |
| Subjects: | |
| Online Access: | https://elifesciences.org/articles/16262 |
| _version_ | 1811200338842091520 |
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| author | Wenjing Sun Elizabeth A Matthews Vicky Nicolas Susanne Schoch Dirk Dietrich |
| author_facet | Wenjing Sun Elizabeth A Matthews Vicky Nicolas Susanne Schoch Dirk Dietrich |
| author_sort | Wenjing Sun |
| collection | DOAJ |
| description | Synaptic signaling to NG2-expressing oligodendrocyte precursor cells (NG2 cells) could be key to rendering myelination of axons dependent on neuronal activity, but it has remained unclear whether NG2 glial cells integrate and respond to synaptic input. Here we show that NG2 cells perform linear integration of glutamatergic synaptic inputs and respond with increasing dendritic calcium elevations. Synaptic activity induces rapid Ca2+ signals mediated by low-voltage activated Ca2+ channels under strict inhibitory control of voltage-gated A-type K+ channels. Ca2+ signals can be global and originate throughout the cell. However, voltage-gated channels are also found in thin dendrites which act as compartmentalized processing units and generate local calcium transients. Taken together, the activity-dependent control of Ca2+ signals by A-type channels and the global versus local signaling domains make intracellular Ca2+ in NG2 cells a prime signaling molecule to transform neurotransmitter release into activity-dependent myelination. |
| first_indexed | 2024-04-12T02:03:13Z |
| format | Article |
| id | doaj.art-2f19e1f893f4424997f317fca6fc0ae7 |
| institution | Directory Open Access Journal |
| issn | 2050-084X |
| language | English |
| last_indexed | 2024-04-12T02:03:13Z |
| publishDate | 2016-09-01 |
| publisher | eLife Sciences Publications Ltd |
| record_format | Article |
| series | eLife |
| spelling | doaj.art-2f19e1f893f4424997f317fca6fc0ae72022-12-22T03:52:36ZengeLife Sciences Publications LtdeLife2050-084X2016-09-01510.7554/eLife.16262NG2 glial cells integrate synaptic input in global and dendritic calcium signalsWenjing Sun0https://orcid.org/0000-0002-0905-7420Elizabeth A Matthews1Vicky Nicolas2Susanne Schoch3Dirk Dietrich4https://orcid.org/0000-0002-4307-2448Department of Neurosurgery, University Clinic Bonn, Bonn, GermanyDepartment of Neurosurgery, University Clinic Bonn, Bonn, GermanyDepartment of Neurosurgery, University Clinic Bonn, Bonn, GermanyDepartment of Neuropathology, University Clinic Bonn, Bonn, GermanyDepartment of Neurosurgery, University Clinic Bonn, Bonn, GermanySynaptic signaling to NG2-expressing oligodendrocyte precursor cells (NG2 cells) could be key to rendering myelination of axons dependent on neuronal activity, but it has remained unclear whether NG2 glial cells integrate and respond to synaptic input. Here we show that NG2 cells perform linear integration of glutamatergic synaptic inputs and respond with increasing dendritic calcium elevations. Synaptic activity induces rapid Ca2+ signals mediated by low-voltage activated Ca2+ channels under strict inhibitory control of voltage-gated A-type K+ channels. Ca2+ signals can be global and originate throughout the cell. However, voltage-gated channels are also found in thin dendrites which act as compartmentalized processing units and generate local calcium transients. Taken together, the activity-dependent control of Ca2+ signals by A-type channels and the global versus local signaling domains make intracellular Ca2+ in NG2 cells a prime signaling molecule to transform neurotransmitter release into activity-dependent myelination.https://elifesciences.org/articles/16262NG2 cellssynaptic integrationcalcium signalingA-type potassium channels |
| spellingShingle | Wenjing Sun Elizabeth A Matthews Vicky Nicolas Susanne Schoch Dirk Dietrich NG2 glial cells integrate synaptic input in global and dendritic calcium signals eLife NG2 cells synaptic integration calcium signaling A-type potassium channels |
| title | NG2 glial cells integrate synaptic input in global and dendritic calcium signals |
| title_full | NG2 glial cells integrate synaptic input in global and dendritic calcium signals |
| title_fullStr | NG2 glial cells integrate synaptic input in global and dendritic calcium signals |
| title_full_unstemmed | NG2 glial cells integrate synaptic input in global and dendritic calcium signals |
| title_short | NG2 glial cells integrate synaptic input in global and dendritic calcium signals |
| title_sort | ng2 glial cells integrate synaptic input in global and dendritic calcium signals |
| topic | NG2 cells synaptic integration calcium signaling A-type potassium channels |
| url | https://elifesciences.org/articles/16262 |
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