Synthesis, modeling, and biological studies of new thiazole-pyrazole analogues as anticancer agents

Synthesis, modeling, and biological studies of new thiazole-pyrazole analogues as anticancer agents

A series of various substituted thiazole-pyrazole hybrids 5, 7, 8, and 9 were synthesized, and their chemical structures were confirmed by spectral data (infrared, 1H & 13C NMR and Mass). The frontier molecular orbital structural and energetic properties of the targeting thiazole-pyrazole hy...

Full description

Bibliographic Details
Main Authors:	Gadeer R.S. Ashour, Ahmad Fawzi Qarah, Abdulmajeed F. Alrefaei, Adel I. Alalawy, Amerah Alsoliemy, Alaa M. Alqahtani, Wael M. Alamoudi, Nashwa M. El-Metwaly
Format:	Article
Language:	English
Published:	Elsevier 2023-07-01
Series:	Journal of Saudi Chemical Society
Subjects:	Thiosemicarbazone 4-chlorophenacyl bromide Thiazole-pyrazole hybrids DFT/B3LYP Cytotoxicity Carbonic anhydrases
Online Access:	http://www.sciencedirect.com/science/article/pii/S131961032300073X

Similar Items

Synthesis of phenylthiourea-based pyrazole, thiazole and/or pyran compounds: molecular modeling and biological activity
by: Ahmad Fawzi Qarah, et al.
Published: (2023-12-01)

Synthesis and cytotoxicity evaluation of thiosemicarbazones and their thiazole derivatives
by: Saulo Feheiberg Pinto Braga, et al.

2-[3-(4-Chlorophenyl)-5-(4-fluorophenyl)-4,5-dihydro-1H-pyrazol-1-yl]-8H-indeno[1,2-d]thiazole
by: Gamal A. El-Hiti, et al.
Published: (2019-02-01)

2-{5-(1,3-Benzodioxol-5-yl)-1-[4-(4-chlorophenyl)-1,3-thiazol-2-yl]-4,5-dihydro-1H-pyrazol-3-yl}pyrazine
by: Suban Syed Shafi, et al.
Published: (2010-03-01)

5-(4-Methoxyphenyl)-1-[4-(4-methoxyphenyl)thiazol-2-yl]-3-[4-(prop-2-ynyloxy)phenyl]-4,5-dihydro-1H-pyrazole
by: Sreeramapura D. Archana, et al.
Published: (2022-11-01)

New thiazol-pyridazine derivatives as antimicrobial and antiviral candidates: Synthesis, and application
by: Fuad A. Alatawi, et al.
Published: (2024-03-01)

Novel Structural Hybrids of Pyrrole and Thiazole Moieties: Synthesis and Evaluation of Antibacterial and Antifungal Activities
by: Mohamed Salem, et al.
Published: (2021-12-01)

Synthesis, molecular modeling and bioactivity of new bis-thiazole, thiazole-pyrazole, and thiazole-pyridine analogues
by: Abrar Bayazeed, et al.
Published: (2023-11-01)

Uses of Cyanoacetylhydrazine in Heterocyclic Synthesis: Novel Synthesis of Pyrazole Derivatives with Anti-tumor Activities
by: Mahmoud A. Abdelaziz, et al.
Published: (2012-07-01)

Synthesis, antibacterial, antifungal, antioxidant, cytotoxicity and molecular docking studies of thiazole derivatives
by: Keshav B. Gangurde, et al.
Published: (2024-01-01)

Design, synthesis and biological evaluation of 1,3,4-oxadiazoles/thiadiazoles bearing pyrazole scaffold as antimicrobial and antioxidant candidates
by: Pavithra Gurunanjappa, et al.
Published: (2016-07-01)

Synthesis of new thiazolyl-thienyl and thiazolyl-thiadiazolyl ketones: Molecular modelling and docking studies as antimicrobial agents
by: Haifa Alharbi, et al.
Published: (2024-01-01)

Synthesis, Characterization and Biological Activity Evaluation of Some Pyrazoles, Thiazoles and Oxazoles Derived from 2-Mercaptoaniline
by: Ahmood Kh. Jebur AL-Joubory, et al.
Published: (2021-03-01)

Antiparasitic Behavior of Trifluoromethylated Pyrazole 2-Amino-1,3,4-thiadiazole Hybrids and Their Analogues: Synthesis and Structure-Activity Relationship
by: Jeniffer do Nascimento Ascencio Camargo, et al.
Published: (2020-10-01)

2-[3-(4-Chlorophenyl)-5-(4-fluorophenyl)-4,5-dihydro-1H-pyrazol-1-yl]-5-[(4-fluorophenyl)diazenyl]-4-methylthiazole
by: Saud A. Alanazi, et al.
Published: (2020-05-01)

Pyrazole Incorporated New Thiosemicarbazones: Design, Synthesis and Investigation of DPP-4 Inhibitory Effects
by: Belgin Sever, et al.
Published: (2020-10-01)

4-(4-Bromophenyl)-2-(3-(4-chlorophenyl)-5-{3-[5-methyl-1-(4-methylphenyl)-1H-1,2,3-triazol-4-yl]-1-phenyl-1H-pyrazol-4-yl}-4,5-dihydro-1H-pyrazol-1-yl)-1,3-thiazole
by: Gamal A. El-Hiti, et al.
Published: (2018-03-01)

4-(4-Bromophenyl)-2-(3-(4-bromophenyl)-5-{3-[5-methyl-1-(4-methylphenyl)-1H-1,2,3-triazol-4-yl]-1-phenyl-1H-pyrazol-4-yl}-4,5-dihydro-1H-pyrazol-1-yl)-1,3-thiazole
by: Gamal A. El-Hiti, et al.
Published: (2018-03-01)

Synthesis, antimicrobial and antioxidant activity of triazole, pyrazole containing thiazole derivatives and molecular docking studies on COVID-19
by: Raghavender Matta, et al.
Published: (2023-06-01)

Green Synthesis and Molecular Docking Study of Some New Thiazoles Using Terephthalohydrazide Chitosan Hydrogel as Ecofriendly Biopolymeric Catalyst
by: Jehan Y. Al-Humaidi, et al.
Published: (2023-09-01)

A facile access and evaluation of some novel thiazole and 1,3,4-thiadiazole derivatives incorporating thiazole moiety as potent anticancer agents
by: Sobhi M. Gomha, et al.
Published: (2017-10-01)

Studies on the Synthesis and Reactivity of Novel Benzofuran-2-yl-[3-Methyl-3-Phenylcyclobutyl] Methanones and their Antimicrobial Activity
by: Cavit Kazaz, et al.
Published: (2005-08-01)

5-(4-Fluorophenyl)-1-[4-(4-methylphenyl)thiazol-2-yl]-3-[4-(prop-2-ynyloxy)phenyl]-4,5-dihydro-1H-pyrazole
by: Sreeramapura D. Archana, et al.
Published: (2022-10-01)

Design, synthesis and molecular modelling studies of some pyrazole derivatives as carbonic anhydrase inhibitors
by: Yazgı Dizdaroglu, et al.
Published: (2020-01-01)

Carbonic Anhydrase Inhibition with Sulfonamides Incorporating Pyrazole- and Pyridazinecarboxamide Moieties Provides Examples of Isoform-Selective Inhibitors
by: Andrea Angeli, et al.
Published: (2021-11-01)

Synthesis, molecular docking, in silico study, and evaluation of bis-thiazole-based curcumin derivatives as potential antimicrobial agents
by: Sobhi M. Gomha, et al.
Published: (2024-01-01)

Synthesis and carbonic anhydrase I, II, VII, and IX inhibition studies with a series of benzo[d]thiazole-5- and 6-sulfonamides
by: Morteza Abdoli, et al.
Published: (2017-01-01)

(Hetero)aryl substituted thiazol-2,4-yl scaffold as human carbonic anhydrase I, II, VII and XIV activators
by: Marouan Rami, et al.
Published: (2019-01-01)

Improvement of dye-sensitized solar cells' performance via co-sensitization of new azo thiazole organic dyes with ruthenium (II) based N-719 dye
by: Salhah D. Al-Qahtani, et al.
Published: (2023-05-01)

Convenient Synthesis, Characterization, Cytotoxicity and Toxicity of Pyrazole Derivatives
by: Mona Kamel
Published: (2015-01-01)

Synthesis, in-silico studies, and biological evaluation of some novel 3-thiazolyl-indoles as CDK2–inhibitors
by: Sobhi M. Gomha, et al.
Published: (2023-12-01)

Uses of 3-(2-Bromoacetyl)-2H-chromen-2-one in the Synthesis of Heterocyclic Compounds Incorporating Coumarin: Synthesis, Characterization and Cytotoxicity
by: Rafat M. Mohareb, et al.
Published: (2015-06-01)

New pyrazolyl-thiazolidinone/thiazole derivatives as celecoxib/dasatinib analogues with selective COX-2, HER-2 and EGFR inhibitory effects: design, synthesis, anti-inflammatory/anti-proliferative activities, apoptosis, molecular modelling and ADME studies
by: Wael A. A. Fadaly, et al.
Published: (2023-12-01)

Synthesis, molecular modelling and docking studies of new thieno[2,3-b:4,5-b′] dipyridine compounds as antimicrobial agents
by: Noof A. Alenazi, et al.
Published: (2023-07-01)

Favorable Heteroaromatic Thiazole-Based Polyurea Derivatives as Interesting Biologically Active Products
by: Mostafa A. Hussien, et al.
Published: (2023-06-01)

Synthesis and characterization of some heterocyclic including oxazoles,Thiazoles, Pyridazines, phthalizines and Pyrazoles with evaluating of biological activity.
by: Baghdad Science Journal
Published: (2013-09-01)

Synthesis, characterization and in vitro inhibition of metal complexes of pyrazole based sulfonamide on human erythrocyte carbonic anhydrase isozymes I and II
by: Nurgün Büyükkıdan, et al.
Published: (2017-01-01)

Synthetic Routes to Coumarin(Benzopyrone)-Fused Five-Membered Aromatic Heterocycles Built on the α-Pyrone Moiety. Part II: Five-Membered Aromatic Rings with Multi Heteroatoms
by: Eslam Reda El-Sawy, et al.
Published: (2021-06-01)

Microwave-Assisted Synthesis of some Novel Azoles and Azolopyrimidines as Antimicrobial Agents
by: Sobhi M. Gomha, et al.
Published: (2017-02-01)

Effect of hydrophobic extension of aryl enaminones and pyrazole-linked compounds combined with sulphonamide, sulfaguanidine, or carboxylic acid functionalities on carbonic anhydrase inhibitory potency and selectivity
by: Heba Abdelrasheed Allam, et al.
Published: (2023-12-01)