Effect of an Enriched Protein Drink on Muscle Mass and Glycemic Control during Combined Lifestyle Intervention in Older Adults with Obesity and Type 2 Diabetes: A Double-Blind RCT
Background: Weight loss is key to treatment of older adults with obesity and type 2 diabetes, but also a risk for muscle mass loss. This study investigated whether a whey protein drink enriched with leucine and vitamin D could preserve muscle mass and improve glycemic control during combined lifesty...
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MDPI AG
2020-12-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/13/1/64 |
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| author | Robert G. Memelink Wilrike J. Pasman Anke Bongers Anita Tump Annemieke van Ginkel Wim Tromp Suzan Wopereis Sjors Verlaan Johan de Vogel-van den Bosch Peter J. M. Weijs |
| author_facet | Robert G. Memelink Wilrike J. Pasman Anke Bongers Anita Tump Annemieke van Ginkel Wim Tromp Suzan Wopereis Sjors Verlaan Johan de Vogel-van den Bosch Peter J. M. Weijs |
| author_sort | Robert G. Memelink |
| collection | DOAJ |
| description | Background: Weight loss is key to treatment of older adults with obesity and type 2 diabetes, but also a risk for muscle mass loss. This study investigated whether a whey protein drink enriched with leucine and vitamin D could preserve muscle mass and improve glycemic control during combined lifestyle intervention in this population. Methods: 123 older adults with obesity and type 2 diabetes were randomized into a 13-week lifestyle intervention with dietary advice and exercise, receiving either the enriched protein drink (test) or an isocaloric control (control). Muscle mass was assessed with dual-energy X-ray absorptiometry and glycemic control by oral glucose tolerance test. Statistical analyses were performed using a linear mixed model. Results: There was a nonsignificant increase in leg muscle mass (+0.28 kg; 95% CI, −0.01 to 0.56) and a significant increase in appendicular muscle mass (+0.36 kg; 95% CI, 0.005 to 0.71) and total lean mass (+0.92 kg; 95% CI, 0.19 to 1.65) in test vs. control. Insulin sensitivity (Matsuda index) also increased in test vs. control (+0.52; 95% CI, 0.07 to 0.97). Conclusions: Use of an enriched protein drink during combined lifestyle intervention shows beneficial effects on muscle mass and glycemic control in older adults with obesity and type 2 diabetes. |
| first_indexed | 2024-03-10T13:43:22Z |
| format | Article |
| id | doaj.art-2f1a90282f6246f898487a23b028a76c |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-10T13:43:22Z |
| publishDate | 2020-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-2f1a90282f6246f898487a23b028a76c2023-11-21T02:46:43ZengMDPI AGNutrients2072-66432020-12-011316410.3390/nu13010064Effect of an Enriched Protein Drink on Muscle Mass and Glycemic Control during Combined Lifestyle Intervention in Older Adults with Obesity and Type 2 Diabetes: A Double-Blind RCTRobert G. Memelink0Wilrike J. Pasman1Anke Bongers2Anita Tump3Annemieke van Ginkel4Wim Tromp5Suzan Wopereis6Sjors Verlaan7Johan de Vogel-van den Bosch8Peter J. M. Weijs9Department of Nutrition and Dietetics, Faculty of Sports and Nutrition, Center of Expertise Urban Vitality, Amsterdam University of Applied Sciences, 1067 SM Amsterdam, The NetherlandsNetherlands Organisation for Applied Scientific Research (TNO), 3704 HE Zeist, The NetherlandsDanone Nutricia Research, Specialized Nutrition, 3584 CT Utrecht, The NetherlandsVialente-Diëtheek, 3447 GW Woerden, The NetherlandsVialente-Diëtheek, 3447 GW Woerden, The NetherlandsTromp Medical, 1901 ND Castricum, The NetherlandsNetherlands Organisation for Applied Scientific Research (TNO), 3704 HE Zeist, The NetherlandsDepartment of Rehabilitation Medicine, Amsterdam University Medical Centers, Vrije Universiteit, 1081 HV Amsterdam, The NetherlandsDanone Nutricia Research, Specialized Nutrition, 3584 CT Utrecht, The NetherlandsDepartment of Nutrition and Dietetics, Faculty of Sports and Nutrition, Center of Expertise Urban Vitality, Amsterdam University of Applied Sciences, 1067 SM Amsterdam, The NetherlandsBackground: Weight loss is key to treatment of older adults with obesity and type 2 diabetes, but also a risk for muscle mass loss. This study investigated whether a whey protein drink enriched with leucine and vitamin D could preserve muscle mass and improve glycemic control during combined lifestyle intervention in this population. Methods: 123 older adults with obesity and type 2 diabetes were randomized into a 13-week lifestyle intervention with dietary advice and exercise, receiving either the enriched protein drink (test) or an isocaloric control (control). Muscle mass was assessed with dual-energy X-ray absorptiometry and glycemic control by oral glucose tolerance test. Statistical analyses were performed using a linear mixed model. Results: There was a nonsignificant increase in leg muscle mass (+0.28 kg; 95% CI, −0.01 to 0.56) and a significant increase in appendicular muscle mass (+0.36 kg; 95% CI, 0.005 to 0.71) and total lean mass (+0.92 kg; 95% CI, 0.19 to 1.65) in test vs. control. Insulin sensitivity (Matsuda index) also increased in test vs. control (+0.52; 95% CI, 0.07 to 0.97). Conclusions: Use of an enriched protein drink during combined lifestyle intervention shows beneficial effects on muscle mass and glycemic control in older adults with obesity and type 2 diabetes.https://www.mdpi.com/2072-6643/13/1/64overweightweight lossdiabeteselderlyproteinlean mass |
| spellingShingle | Robert G. Memelink Wilrike J. Pasman Anke Bongers Anita Tump Annemieke van Ginkel Wim Tromp Suzan Wopereis Sjors Verlaan Johan de Vogel-van den Bosch Peter J. M. Weijs Effect of an Enriched Protein Drink on Muscle Mass and Glycemic Control during Combined Lifestyle Intervention in Older Adults with Obesity and Type 2 Diabetes: A Double-Blind RCT Nutrients overweight weight loss diabetes elderly protein lean mass |
| title | Effect of an Enriched Protein Drink on Muscle Mass and Glycemic Control during Combined Lifestyle Intervention in Older Adults with Obesity and Type 2 Diabetes: A Double-Blind RCT |
| title_full | Effect of an Enriched Protein Drink on Muscle Mass and Glycemic Control during Combined Lifestyle Intervention in Older Adults with Obesity and Type 2 Diabetes: A Double-Blind RCT |
| title_fullStr | Effect of an Enriched Protein Drink on Muscle Mass and Glycemic Control during Combined Lifestyle Intervention in Older Adults with Obesity and Type 2 Diabetes: A Double-Blind RCT |
| title_full_unstemmed | Effect of an Enriched Protein Drink on Muscle Mass and Glycemic Control during Combined Lifestyle Intervention in Older Adults with Obesity and Type 2 Diabetes: A Double-Blind RCT |
| title_short | Effect of an Enriched Protein Drink on Muscle Mass and Glycemic Control during Combined Lifestyle Intervention in Older Adults with Obesity and Type 2 Diabetes: A Double-Blind RCT |
| title_sort | effect of an enriched protein drink on muscle mass and glycemic control during combined lifestyle intervention in older adults with obesity and type 2 diabetes a double blind rct |
| topic | overweight weight loss diabetes elderly protein lean mass |
| url | https://www.mdpi.com/2072-6643/13/1/64 |
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