Meloxicam in rheumatology practice: The history of its use in the therapy of pain
Nonsteroidal anti-inflammatory drugs (NSAIDs) are widely used to treat pain syndrome in acute and chronic diseases of various genesis, which are accompanied by pain and inflammation. However, the use of NSAIDs is partially limited by their adverse reactions (ARs), so great attention has been recentl...
| Main Authors: | , |
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| Format: | Article |
| Language: | Russian |
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IMA-PRESS LLC
2016-06-01
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| Series: | Современная ревматология |
| Subjects: | |
| Online Access: | https://mrj.ima-press.net/mrj/article/view/684 |
| _version_ | 1797876813036257280 |
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| author | L. I. Alekseeva P. S. Kovalenko |
| author_facet | L. I. Alekseeva P. S. Kovalenko |
| author_sort | L. I. Alekseeva |
| collection | DOAJ |
| description | Nonsteroidal anti-inflammatory drugs (NSAIDs) are widely used to treat pain syndrome in acute and chronic diseases of various genesis, which are accompanied by pain and inflammation. However, the use of NSAIDs is partially limited by their adverse reactions (ARs), so great attention has been recently given to the safety of NSAIDs and to the elaboration of guidelines for their administration. Therapy with NSAIDs requires that a physician should be aware of not only the mechanism of their action, but also the possible ARs, as well as their risk factors and ways of correction. It is emphasized that NSAIDs should be prescribed in terms of the possible risk of complications in different organs and tissues. The review considers the gastrointestinal, renal, and cardiac safety of NSAIDs, such as the extensively used drug meloxicam in particular. Meloxicam is as effective as nonselective NSAIDs, but due to the primary inhibition of cyclooxygenase-2, it has also a better safety profile: when it is used, there are rare gastrointestinal complications and a low cardiovascular risk that is chiefly represented by a vascular component, which makes possible to use it with caution in patients at cardiovascular risk. The results of numerous investigations show that meloxicam has a good efficacy/safety ratio and noticeable analgesic and anti-inflammatory effects, which makes it the drug of choice for the treatment of a wide range of rheumatic diseases and acute and chronic diseases of the joint and spinal column. It is pointed out that there is a need for further clinical trials of the safety of meloxicam to specify individual mechanisms of its cardiotoxicity. |
| first_indexed | 2024-04-10T02:07:14Z |
| format | Article |
| id | doaj.art-2f1b7f34faeb40868ae81bfc7dbecffb |
| institution | Directory Open Access Journal |
| issn | 1996-7012 2310-158X |
| language | Russian |
| last_indexed | 2024-04-10T02:07:14Z |
| publishDate | 2016-06-01 |
| publisher | IMA-PRESS LLC |
| record_format | Article |
| series | Современная ревматология |
| spelling | doaj.art-2f1b7f34faeb40868ae81bfc7dbecffb2023-03-13T08:39:24ZrusIMA-PRESS LLCСовременная ревматология1996-70122310-158X2016-06-01102505510.14412/1996-7012-2016-2-50-551975Meloxicam in rheumatology practice: The history of its use in the therapy of painL. I. Alekseeva0P. S. Kovalenko1ФГБНУ Научно-исследовательский институт ревматологии им. В.А. Насоновой, Москва, Россия 115522, Москва, Каширское шоссе 34АФГБНУ Научно-исследовательский институт ревматологии им. В.А. Насоновой, Москва, Россия 115522, Москва, Каширское шоссе 34АNonsteroidal anti-inflammatory drugs (NSAIDs) are widely used to treat pain syndrome in acute and chronic diseases of various genesis, which are accompanied by pain and inflammation. However, the use of NSAIDs is partially limited by their adverse reactions (ARs), so great attention has been recently given to the safety of NSAIDs and to the elaboration of guidelines for their administration. Therapy with NSAIDs requires that a physician should be aware of not only the mechanism of their action, but also the possible ARs, as well as their risk factors and ways of correction. It is emphasized that NSAIDs should be prescribed in terms of the possible risk of complications in different organs and tissues. The review considers the gastrointestinal, renal, and cardiac safety of NSAIDs, such as the extensively used drug meloxicam in particular. Meloxicam is as effective as nonselective NSAIDs, but due to the primary inhibition of cyclooxygenase-2, it has also a better safety profile: when it is used, there are rare gastrointestinal complications and a low cardiovascular risk that is chiefly represented by a vascular component, which makes possible to use it with caution in patients at cardiovascular risk. The results of numerous investigations show that meloxicam has a good efficacy/safety ratio and noticeable analgesic and anti-inflammatory effects, which makes it the drug of choice for the treatment of a wide range of rheumatic diseases and acute and chronic diseases of the joint and spinal column. It is pointed out that there is a need for further clinical trials of the safety of meloxicam to specify individual mechanisms of its cardiotoxicity.https://mrj.ima-press.net/mrj/article/view/684нестероидные противовоспалительные препаратытерапия боли и воспалениябезопасностьосложнениямелоксикам. |
| spellingShingle | L. I. Alekseeva P. S. Kovalenko Meloxicam in rheumatology practice: The history of its use in the therapy of pain Современная ревматология нестероидные противовоспалительные препараты терапия боли и воспаления безопасность осложнения мелоксикам. |
| title | Meloxicam in rheumatology practice: The history of its use in the therapy of pain |
| title_full | Meloxicam in rheumatology practice: The history of its use in the therapy of pain |
| title_fullStr | Meloxicam in rheumatology practice: The history of its use in the therapy of pain |
| title_full_unstemmed | Meloxicam in rheumatology practice: The history of its use in the therapy of pain |
| title_short | Meloxicam in rheumatology practice: The history of its use in the therapy of pain |
| title_sort | meloxicam in rheumatology practice the history of its use in the therapy of pain |
| topic | нестероидные противовоспалительные препараты терапия боли и воспаления безопасность осложнения мелоксикам. |
| url | https://mrj.ima-press.net/mrj/article/view/684 |
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