Effectiveness of vitamin E on oral mucositis caused by radiotherapy and chemotherapy: a meta-analysis
Objective·To examine, using a systematic review and meta-analysis, the effectiveness of vitamin E on treating oral mucositis caused by radiotherapy and chemotherapy.Methods·A systematic literature search was performed by using PubMed, Embase, Cochrane Library, Web of Science, CINAHL, OpenGrey, Chine...
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| Format: | Article |
| Language: | zho |
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Editorial Office of Journal of Shanghai Jiao Tong University (Medical Science)
2023-02-01
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| Series: | Shanghai Jiaotong Daxue xuebao. Yixue ban |
| Subjects: | |
| Online Access: | https://xuebao.shsmu.edu.cn/article/2023/1674-8115/1674-8115-2023-43-2-208.shtml |
| _version_ | 1797385338131316736 |
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| author | LIANG Yanjing HUANG Chuxian LI Hongyan HOU Lili |
| author_facet | LIANG Yanjing HUANG Chuxian LI Hongyan HOU Lili |
| author_sort | LIANG Yanjing |
| collection | DOAJ |
| description | Objective·To examine, using a systematic review and meta-analysis, the effectiveness of vitamin E on treating oral mucositis caused by radiotherapy and chemotherapy.Methods·A systematic literature search was performed by using PubMed, Embase, Cochrane Library, Web of Science, CINAHL, OpenGrey, Chinese biomedical literature database (CBM), Chinese national knowledge infrastructure (CNKI), Wanfang Data, and China Science and Technology Journal Database (VIP). The retrieval time was up to March 2022. The risk of bias was assessed by using the Cochrane Risk-of-Bias tool, version 2.0. RevMan 5.4 was used for meta-analysis.Results·A total of 563 literatures were retrieved. A total of 7 randomized controlled trials were included. The results of meta-analysis revealed that vitamin E supplementation did not significantly affect oral mucositis caused by chemoradiotherapy (RR=0.44, 95%CI 0.15‒1.25, Z=1.54, P=0.120). However, vitamin E may have some effect on severe oral mucositis (RR=0.22, 95%CI 0.11‒0.43, Z=4.33, P=0.000).Conclusion·It cannot be explained that vitamin E can effectively treat oral mucositis caused by radiotherapy and chemotherapy, but vitamin E may be effective for severe oral mucositis. |
| first_indexed | 2024-03-08T21:52:49Z |
| format | Article |
| id | doaj.art-2f1bea89b9494138b22784c669c08cbb |
| institution | Directory Open Access Journal |
| issn | 1674-8115 |
| language | zho |
| last_indexed | 2024-03-08T21:52:49Z |
| publishDate | 2023-02-01 |
| publisher | Editorial Office of Journal of Shanghai Jiao Tong University (Medical Science) |
| record_format | Article |
| series | Shanghai Jiaotong Daxue xuebao. Yixue ban |
| spelling | doaj.art-2f1bea89b9494138b22784c669c08cbb2023-12-20T06:06:03ZzhoEditorial Office of Journal of Shanghai Jiao Tong University (Medical Science)Shanghai Jiaotong Daxue xuebao. Yixue ban1674-81152023-02-0143220821410.3969/j.issn.1674-8115.2023.02.0101674-8115（2023）02-0208-07Effectiveness of vitamin E on oral mucositis caused by radiotherapy and chemotherapy: a meta-analysisLIANG Yanjing0HUANG Chuxian1LI Hongyan2HOU Lili3School of Nursing, Shanghai Jiao Tong University, Shanghai 200025, ChinaSchool of Nursing, Shanghai Jiao Tong University, Shanghai 200025, ChinaSchool of Nursing, Shanghai Jiao Tong University, Shanghai 200025, ChinaSchool of Nursing, Shanghai Jiao Tong University, Shanghai 200025, ChinaObjective·To examine, using a systematic review and meta-analysis, the effectiveness of vitamin E on treating oral mucositis caused by radiotherapy and chemotherapy.Methods·A systematic literature search was performed by using PubMed, Embase, Cochrane Library, Web of Science, CINAHL, OpenGrey, Chinese biomedical literature database (CBM), Chinese national knowledge infrastructure (CNKI), Wanfang Data, and China Science and Technology Journal Database (VIP). The retrieval time was up to March 2022. The risk of bias was assessed by using the Cochrane Risk-of-Bias tool, version 2.0. RevMan 5.4 was used for meta-analysis.Results·A total of 563 literatures were retrieved. A total of 7 randomized controlled trials were included. The results of meta-analysis revealed that vitamin E supplementation did not significantly affect oral mucositis caused by chemoradiotherapy (RR=0.44, 95%CI 0.15‒1.25, Z=1.54, P=0.120). However, vitamin E may have some effect on severe oral mucositis (RR=0.22, 95%CI 0.11‒0.43, Z=4.33, P=0.000).Conclusion·It cannot be explained that vitamin E can effectively treat oral mucositis caused by radiotherapy and chemotherapy, but vitamin E may be effective for severe oral mucositis.https://xuebao.shsmu.edu.cn/article/2023/1674-8115/1674-8115-2023-43-2-208.shtmlvitamin eoral mucositisrandomized controlled trialmeta analysis |
| spellingShingle | LIANG Yanjing HUANG Chuxian LI Hongyan HOU Lili Effectiveness of vitamin E on oral mucositis caused by radiotherapy and chemotherapy: a meta-analysis Shanghai Jiaotong Daxue xuebao. Yixue ban vitamin e oral mucositis randomized controlled trial meta analysis |
| title | Effectiveness of vitamin E on oral mucositis caused by radiotherapy and chemotherapy: a meta-analysis |
| title_full | Effectiveness of vitamin E on oral mucositis caused by radiotherapy and chemotherapy: a meta-analysis |
| title_fullStr | Effectiveness of vitamin E on oral mucositis caused by radiotherapy and chemotherapy: a meta-analysis |
| title_full_unstemmed | Effectiveness of vitamin E on oral mucositis caused by radiotherapy and chemotherapy: a meta-analysis |
| title_short | Effectiveness of vitamin E on oral mucositis caused by radiotherapy and chemotherapy: a meta-analysis |
| title_sort | effectiveness of vitamin e on oral mucositis caused by radiotherapy and chemotherapy a meta analysis |
| topic | vitamin e oral mucositis randomized controlled trial meta analysis |
| url | https://xuebao.shsmu.edu.cn/article/2023/1674-8115/1674-8115-2023-43-2-208.shtml |
| work_keys_str_mv | AT liangyanjing effectivenessofvitamineonoralmucositiscausedbyradiotherapyandchemotherapyametaanalysis AT huangchuxian effectivenessofvitamineonoralmucositiscausedbyradiotherapyandchemotherapyametaanalysis AT lihongyan effectivenessofvitamineonoralmucositiscausedbyradiotherapyandchemotherapyametaanalysis AT houlili effectivenessofvitamineonoralmucositiscausedbyradiotherapyandchemotherapyametaanalysis |