Efficacy and Safety of Bempedoic Acid in Patients With Hypercholesterolemia and Statin Intolerance

Efficacy and Safety of Bempedoic Acid in Patients With Hypercholesterolemia and Statin Intolerance

Background Inability to tolerate statins because of muscle symptoms contributes to uncontrolled cholesterol levels and insufficient cardiovascular risk reduction. Bempedoic acid, a prodrug that is activated by a hepatic enzyme not present in skeletal muscle, inhibits ATP‐citrate lyase, an enzyme ups...

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Bibliographic Details
Main Authors: Ulrich Laufs, Maciej Banach, G. B. John Mancini, Daniel Gaudet, LeAnne T. Bloedon, Lulu Ren Sterling, Stephanie Kelly, Erik S. G. Stroes
Format: Article
Language:English
Published: Wiley 2019-04-01
Series:Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Subjects:
hypercholesterolemia
lipids
low‐density lipoprotein cholesterol
muscle
statin
Online Access:https://www.ahajournals.org/doi/10.1161/JAHA.118.011662

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