Metformin effect on gut microbiota: insights for HIV-related inflammation
Abstract The gut microbiota is emerging as a prominent player in maintaining health through several metabolic and immune pathways. Dysregulation of gut microbiota composition, also known as dysbiosis, is involved in the clinical outcome of diabetes, inflammatory bowel diseases, cancer, aging and HIV...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2020-03-01
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| Series: | AIDS Research and Therapy |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s12981-020-00267-2 |
| _version_ | 1830514971874689024 |
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| author | Jing Ouyang Stéphane Isnard John Lin Brandon Fombuena André Marette Bertrand Routy Yaokai Chen Jean-Pierre Routy |
| author_facet | Jing Ouyang Stéphane Isnard John Lin Brandon Fombuena André Marette Bertrand Routy Yaokai Chen Jean-Pierre Routy |
| author_sort | Jing Ouyang |
| collection | DOAJ |
| description | Abstract The gut microbiota is emerging as a prominent player in maintaining health through several metabolic and immune pathways. Dysregulation of gut microbiota composition, also known as dysbiosis, is involved in the clinical outcome of diabetes, inflammatory bowel diseases, cancer, aging and HIV infection. Gut dysbiosis and inflammation persist in people living with HIV (PLWH) despite receiving antiretroviral therapy, further contributing to non-AIDS comorbidities. Metformin, a widely used antidiabetic agent, has been found to benefit microbiota composition, promote gut barrier integrity and reduce inflammation in human and animal models of diabetes. Inspired by the effect of metformin on diabetes-related gut dysbiosis, we herein critically review the relevance of metformin to control inflammation in PLWH. Metformin may improve gut microbiota composition, in turn reducing inflammation and risk of non-AIDS comorbidities. This review will pave the way towards innovative strategies to counteract dysregulated microbiota and improve the lives of PLWH. |
| first_indexed | 2024-12-22T03:14:28Z |
| format | Article |
| id | doaj.art-2f1c1d85c98246118d9a27d06201f633 |
| institution | Directory Open Access Journal |
| issn | 1742-6405 |
| language | English |
| last_indexed | 2024-12-22T03:14:28Z |
| publishDate | 2020-03-01 |
| publisher | BMC |
| record_format | Article |
| series | AIDS Research and Therapy |
| spelling | doaj.art-2f1c1d85c98246118d9a27d06201f6332022-12-21T18:40:51ZengBMCAIDS Research and Therapy1742-64052020-03-011711910.1186/s12981-020-00267-2Metformin effect on gut microbiota: insights for HIV-related inflammationJing Ouyang0Stéphane Isnard1John Lin2Brandon Fombuena3André Marette4Bertrand Routy5Yaokai Chen6Jean-Pierre Routy7Chongqing Public Health Medical CenterInfectious Diseases and Immunity in Global Health Program, Research Institute, McGill University Health CentreInfectious Diseases and Immunity in Global Health Program, Research Institute, McGill University Health CentreInfectious Diseases and Immunity in Global Health Program, Research Institute, McGill University Health CentreDepartment of Medicine, Faculty of Medicine, Cardiology Axis of the Québec Heart and Lung Institute, Laval UniversityResearch Centre for the University of Montréal (CRCHUM)Chongqing Public Health Medical CenterInfectious Diseases and Immunity in Global Health Program, Research Institute, McGill University Health CentreAbstract The gut microbiota is emerging as a prominent player in maintaining health through several metabolic and immune pathways. Dysregulation of gut microbiota composition, also known as dysbiosis, is involved in the clinical outcome of diabetes, inflammatory bowel diseases, cancer, aging and HIV infection. Gut dysbiosis and inflammation persist in people living with HIV (PLWH) despite receiving antiretroviral therapy, further contributing to non-AIDS comorbidities. Metformin, a widely used antidiabetic agent, has been found to benefit microbiota composition, promote gut barrier integrity and reduce inflammation in human and animal models of diabetes. Inspired by the effect of metformin on diabetes-related gut dysbiosis, we herein critically review the relevance of metformin to control inflammation in PLWH. Metformin may improve gut microbiota composition, in turn reducing inflammation and risk of non-AIDS comorbidities. This review will pave the way towards innovative strategies to counteract dysregulated microbiota and improve the lives of PLWH.http://link.springer.com/article/10.1186/s12981-020-00267-2MetforminMicrobiotaGut permeabilityInflammationHIV |
| spellingShingle | Jing Ouyang Stéphane Isnard John Lin Brandon Fombuena André Marette Bertrand Routy Yaokai Chen Jean-Pierre Routy Metformin effect on gut microbiota: insights for HIV-related inflammation AIDS Research and Therapy Metformin Microbiota Gut permeability Inflammation HIV |
| title | Metformin effect on gut microbiota: insights for HIV-related inflammation |
| title_full | Metformin effect on gut microbiota: insights for HIV-related inflammation |
| title_fullStr | Metformin effect on gut microbiota: insights for HIV-related inflammation |
| title_full_unstemmed | Metformin effect on gut microbiota: insights for HIV-related inflammation |
| title_short | Metformin effect on gut microbiota: insights for HIV-related inflammation |
| title_sort | metformin effect on gut microbiota insights for hiv related inflammation |
| topic | Metformin Microbiota Gut permeability Inflammation HIV |
| url | http://link.springer.com/article/10.1186/s12981-020-00267-2 |
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