Is PTSD-Phenotype Associated with HPA-Axis Sensitivity? Feedback Inhibition and Other Modulating Factors of Glucocorticoid Signaling Dynamics

Is PTSD-Phenotype Associated with HPA-Axis Sensitivity? Feedback Inhibition and Other Modulating Factors of Glucocorticoid Signaling Dynamics

Previously, we found that basal corticosterone pulsatility significantly impacts the vulnerability for developing post-traumatic stress disorder (PTSD). Rats that exhibited PTSD-phenotype were characterized by blunted basal corticosterone pulsatility amplitude and a blunted corticosterone response t...

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Bibliographic Details
Main Authors: Dor Danan, Doron Todder, Joseph Zohar, Hagit Cohen
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:International Journal of Molecular Sciences
Subjects:
posttraumatic stress disorder
hypothalamus–pituitary–adrenal axis
pulsatility
animal model
corticosterone
glucocorticoid receptor
Online Access:https://www.mdpi.com/1422-0067/22/11/6050

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