The Role of the Adhesion Receptor CD146 and Its Soluble Form in Human Embryo Implantation and Pregnancy
CD146 is an adhesion molecule essentially located in the vascular system, which has been described to play an important role in angiogenesis. A soluble form of CD146, called sCD146, is detected in the bloodstream and is known as an angiogenic factor. During placental development, CD146 is selectivel...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-08-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2021.711394/full |
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| author | Sylvie Bouvier Sylvie Bouvier Sylvie Bouvier Elise Kaspi Ahmad Joshkon Odile Paulmyer-Lacroix Marie-Dominique Piercecchi-Marti Akshita Sharma Aurélie S. Leroyer Alexandrine Bertaud Jean-Christophe Gris Jean-Christophe Gris Jean-Christophe Gris Jean-Christophe Gris Françoise Dignat-George Marcel Blot-Chabaud Nathalie Bardin |
| author_facet | Sylvie Bouvier Sylvie Bouvier Sylvie Bouvier Elise Kaspi Ahmad Joshkon Odile Paulmyer-Lacroix Marie-Dominique Piercecchi-Marti Akshita Sharma Aurélie S. Leroyer Alexandrine Bertaud Jean-Christophe Gris Jean-Christophe Gris Jean-Christophe Gris Jean-Christophe Gris Françoise Dignat-George Marcel Blot-Chabaud Nathalie Bardin |
| author_sort | Sylvie Bouvier |
| collection | DOAJ |
| description | CD146 is an adhesion molecule essentially located in the vascular system, which has been described to play an important role in angiogenesis. A soluble form of CD146, called sCD146, is detected in the bloodstream and is known as an angiogenic factor. During placental development, CD146 is selectively expressed in extravillous trophoblasts. A growing body of evidence shows that CD146 and, in particular, sCD146, regulate extravillous trophoblasts migration and invasion both in vitro and in vivo. Hereby, we review expression and functions of CD146/sCD146 in the obstetrical field, mainly in pregnancy and in embryo implantation. We emphasized the relevance of quantifying sCD146 in the plasma of pregnant women or in embryo supernatant in the case of in vitro fertilization (IVF) to predict pathological pregnancy such as preeclampsia or implantation defect. This review will also shed light on some major results that led us to define CD146/sCD146 as a biomarker of placental development and paves the way toward identification of new therapeutic targets during implantation and pregnancy. |
| first_indexed | 2024-12-22T06:28:21Z |
| format | Article |
| id | doaj.art-2f1eb6c2ccd94ccdb6ef49e95c5175c8 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-12-22T06:28:21Z |
| publishDate | 2021-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-2f1eb6c2ccd94ccdb6ef49e95c5175c82022-12-21T18:35:47ZengFrontiers Media S.A.Frontiers in Immunology1664-32242021-08-011210.3389/fimmu.2021.711394711394The Role of the Adhesion Receptor CD146 and Its Soluble Form in Human Embryo Implantation and PregnancySylvie Bouvier0Sylvie Bouvier1Sylvie Bouvier2Elise Kaspi3Ahmad Joshkon4Odile Paulmyer-Lacroix5Marie-Dominique Piercecchi-Marti6Akshita Sharma7Aurélie S. Leroyer8Alexandrine Bertaud9Jean-Christophe Gris10Jean-Christophe Gris11Jean-Christophe Gris12Jean-Christophe Gris13Françoise Dignat-George14Marcel Blot-Chabaud15Nathalie Bardin16Department of Hematology, Nîmes University Hospital, Nîmes, FranceFaculty of Pharmaceutical and Biological Sciences, University of Montpellier, Montpellier, FranceUA11 Institute Desbrest of Epidemiology and Public Health, INSERM, Univ Montpellier, Montpellier, FranceAix Marseille Univ, APHM, INSERM, MMG, Hôpital la Timone, Service de Biologie Cellulaire, Marseille, FranceAix-Marseille Univ, INSERM, INRAE, C2VN, Marseille, FranceAix Marseille Univ, APHM, Hôpital la Conception, Laboratory of Histology-Embryology/Biology of Reproduction, Marseille, FranceAix Marseille Univ, APHM, CNRS, EFS, ADES, Hôpital La Timone, Forensic Department, Marseille, FranceDepartment of Stem Cell and Regenerative Medicine, Centre for Interdisciplinary Research, DY Patil University, Kolhapur, IndiaAix-Marseille Univ, INSERM, INRAE, C2VN, Marseille, FranceAix-Marseille Univ, INSERM, INRAE, C2VN, Marseille, FranceDepartment of Hematology, Nîmes University Hospital, Nîmes, FranceFaculty of Pharmaceutical and Biological Sciences, University of Montpellier, Montpellier, FranceUA11 Institute Desbrest of Epidemiology and Public Health, INSERM, Univ Montpellier, Montpellier, FranceI.M. Sechenov First Moscow State Medical University, Moscow, Russia0Aix Marseille Univ, APHM, INSERM, INRAE, C2VN, Hôpital la Conception, Laboratoire d’Hématologie, Marseille, FranceAix-Marseille Univ, INSERM, INRAE, C2VN, Marseille, France1Aix Marseille Univ, APHM, INSERM, INRAE, C2VN, Hôpital la Conception, Laboratoire d’Immunologie, Marseille, FranceCD146 is an adhesion molecule essentially located in the vascular system, which has been described to play an important role in angiogenesis. A soluble form of CD146, called sCD146, is detected in the bloodstream and is known as an angiogenic factor. During placental development, CD146 is selectively expressed in extravillous trophoblasts. A growing body of evidence shows that CD146 and, in particular, sCD146, regulate extravillous trophoblasts migration and invasion both in vitro and in vivo. Hereby, we review expression and functions of CD146/sCD146 in the obstetrical field, mainly in pregnancy and in embryo implantation. We emphasized the relevance of quantifying sCD146 in the plasma of pregnant women or in embryo supernatant in the case of in vitro fertilization (IVF) to predict pathological pregnancy such as preeclampsia or implantation defect. This review will also shed light on some major results that led us to define CD146/sCD146 as a biomarker of placental development and paves the way toward identification of new therapeutic targets during implantation and pregnancy.https://www.frontiersin.org/articles/10.3389/fimmu.2021.711394/fullbiomarkerCD146/sCD146fertilityimplantationpregnancypreeclampsia |
| spellingShingle | Sylvie Bouvier Sylvie Bouvier Sylvie Bouvier Elise Kaspi Ahmad Joshkon Odile Paulmyer-Lacroix Marie-Dominique Piercecchi-Marti Akshita Sharma Aurélie S. Leroyer Alexandrine Bertaud Jean-Christophe Gris Jean-Christophe Gris Jean-Christophe Gris Jean-Christophe Gris Françoise Dignat-George Marcel Blot-Chabaud Nathalie Bardin The Role of the Adhesion Receptor CD146 and Its Soluble Form in Human Embryo Implantation and Pregnancy Frontiers in Immunology biomarker CD146/sCD146 fertility implantation pregnancy preeclampsia |
| title | The Role of the Adhesion Receptor CD146 and Its Soluble Form in Human Embryo Implantation and Pregnancy |
| title_full | The Role of the Adhesion Receptor CD146 and Its Soluble Form in Human Embryo Implantation and Pregnancy |
| title_fullStr | The Role of the Adhesion Receptor CD146 and Its Soluble Form in Human Embryo Implantation and Pregnancy |
| title_full_unstemmed | The Role of the Adhesion Receptor CD146 and Its Soluble Form in Human Embryo Implantation and Pregnancy |
| title_short | The Role of the Adhesion Receptor CD146 and Its Soluble Form in Human Embryo Implantation and Pregnancy |
| title_sort | role of the adhesion receptor cd146 and its soluble form in human embryo implantation and pregnancy |
| topic | biomarker CD146/sCD146 fertility implantation pregnancy preeclampsia |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2021.711394/full |
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