| Summary: | Objective: To better understand the potential risks and benefits of adjuvant radiotherapy in patients with intermediate-risk surgical stage I endometrial cancer.
Materials and Methods: A retrospective chart review identified 55 patients with endometrial carcinoma stage IA grade 3, stage IB grade 2, and stage IC grade 1, treated at Taipei Veterans General Hospital, Taipei, Taiwan, between 1980 and 2001. The median duration of follow-up was 47 months, and patient age ranged from 34 to 82 years. One patient had stage IA grade 3 cancer, 52 had stage IB grade 2, and two had stage IC grade 1. Thirty-four patients underwent surgery alone and 21 underwent surgery plus radiotherapy. We determined the outcome of adjuvant treatment with postoperative pelvic radiotherapy or surgery alone, comparing locoregional control, overall survival, and treatment-related morbidity.
Results: There was no statistically significant survival difference between the surgery-only and surgery-plus- radiation groups (p = 0.5927). The 5-year overall survival rates were 97% and 95%, respectively. Univariate analysis of prognostic factors showed that only hypertension influenced survival rate (p < 0.0344). The overall recurrence rate was 3.6% (2/55).
Conclusion: The survival rate was high and the relapse rate was low in intermediate-risk surgical stage I endometrial cancer patients. Radiotherapy may be reserved for recurrence.
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