Expression of Neurokinin B Receptor in the Gingival Squamous Cell Carcinoma Bone Microenvironment
Gingival squamous cell carcinoma (SCC) frequently invades the maxillary or mandibular bone, and bone destruction is known as a key prognostic factor in gingival SCCs. Recently, Neurokinin 3 receptor (NK-3R), the receptor ligand for NK-3, which is a member of the tachykinin family expressed in the ce...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-06-01
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| Series: | Diagnostics |
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| Online Access: | https://www.mdpi.com/2075-4418/11/6/1044 |
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| author | Shoko Yoshida Tsuyoshi Shimo Kiyofumi Takabatake Yurika Murase Kyoichi Obata Tatsuo Okui Yuki Kunisada Soichiro Ibaragi Hitoshi Nagatsuka Akira Sasaki |
| author_facet | Shoko Yoshida Tsuyoshi Shimo Kiyofumi Takabatake Yurika Murase Kyoichi Obata Tatsuo Okui Yuki Kunisada Soichiro Ibaragi Hitoshi Nagatsuka Akira Sasaki |
| author_sort | Shoko Yoshida |
| collection | DOAJ |
| description | Gingival squamous cell carcinoma (SCC) frequently invades the maxillary or mandibular bone, and bone destruction is known as a key prognostic factor in gingival SCCs. Recently, Neurokinin 3 receptor (NK-3R), the receptor ligand for NK-3, which is a member of the tachykinin family expressed in the central nervous system, was identified through pathway analysis as a molecule expressed in osteoclasts induced by the hedgehog signal. Although the expression of NK-3R has been detected in osteoclast and SCC cells at the bone invasion front, the relationship between NK-3R expression and the prognosis of gingival SCC patients remains unclear. In the present study, we retrospectively reviewed 27 patients with gingival SCC who had undergone surgery with curative intent. Significantly higher NK-3R expression in tumor cells was found in a case of jawbone invasion than in a case of exophytic poor jawbone invasion. On the other hand, no significant association was observed between NK-3R tumor-positive cases and tumor size, TNM stage, or tumor differentiation. The survival rate tended to be lower in NK-3R tumor-positive cases, but not significantly. However, the disease-specific survival rate was significantly lower in patients with a large number of NK-3R-positive osteoclasts than in those with a small number of them at the tumor bone invasion front. Our results suggest that NK-3R signaling in the gingival SCC bone microenvironment plays an important role in tumor bone destruction and should be considered a potential therapeutic target in advanced gingival SCC with bone destruction. |
| first_indexed | 2024-03-10T10:39:46Z |
| format | Article |
| id | doaj.art-2f220bbbb1d243e7b33f0b478b57746e |
| institution | Directory Open Access Journal |
| issn | 2075-4418 |
| language | English |
| last_indexed | 2024-03-10T10:39:46Z |
| publishDate | 2021-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diagnostics |
| spelling | doaj.art-2f220bbbb1d243e7b33f0b478b57746e2023-11-21T23:02:20ZengMDPI AGDiagnostics2075-44182021-06-01116104410.3390/diagnostics11061044Expression of Neurokinin B Receptor in the Gingival Squamous Cell Carcinoma Bone MicroenvironmentShoko Yoshida0Tsuyoshi Shimo1Kiyofumi Takabatake2Yurika Murase3Kyoichi Obata4Tatsuo Okui5Yuki Kunisada6Soichiro Ibaragi7Hitoshi Nagatsuka8Akira Sasaki9Department of Oral and Maxillofacial Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700-8525, JapanDivision of Reconstructive Surgery for Oral and Maxillofacial Region, Department of Human Biology and Pathophysiology, School of Dentistry, Health Sciences University of Hokkaido, Hokkaido 061-0293, JapanDepartment of Oral Pathology and Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700-8525, JapanDepartment of Oral and Maxillofacial Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700-8525, JapanDepartment of Oral and Maxillofacial Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700-8525, JapanDepartment of Oral and Maxillofacial Surgery, Faculty of Medicine, Shimane University, Izumo, Shimane 693-8501, JapanDepartment of Oral and Maxillofacial Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700-8525, JapanDepartment of Oral and Maxillofacial Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700-8525, JapanDepartment of Oral Pathology and Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700-8525, JapanDepartment of Oral and Maxillofacial Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700-8525, JapanGingival squamous cell carcinoma (SCC) frequently invades the maxillary or mandibular bone, and bone destruction is known as a key prognostic factor in gingival SCCs. Recently, Neurokinin 3 receptor (NK-3R), the receptor ligand for NK-3, which is a member of the tachykinin family expressed in the central nervous system, was identified through pathway analysis as a molecule expressed in osteoclasts induced by the hedgehog signal. Although the expression of NK-3R has been detected in osteoclast and SCC cells at the bone invasion front, the relationship between NK-3R expression and the prognosis of gingival SCC patients remains unclear. In the present study, we retrospectively reviewed 27 patients with gingival SCC who had undergone surgery with curative intent. Significantly higher NK-3R expression in tumor cells was found in a case of jawbone invasion than in a case of exophytic poor jawbone invasion. On the other hand, no significant association was observed between NK-3R tumor-positive cases and tumor size, TNM stage, or tumor differentiation. The survival rate tended to be lower in NK-3R tumor-positive cases, but not significantly. However, the disease-specific survival rate was significantly lower in patients with a large number of NK-3R-positive osteoclasts than in those with a small number of them at the tumor bone invasion front. Our results suggest that NK-3R signaling in the gingival SCC bone microenvironment plays an important role in tumor bone destruction and should be considered a potential therapeutic target in advanced gingival SCC with bone destruction.https://www.mdpi.com/2075-4418/11/6/1044neurokinin B receptorgingival squamous cell carcinomaosteoclast |
| spellingShingle | Shoko Yoshida Tsuyoshi Shimo Kiyofumi Takabatake Yurika Murase Kyoichi Obata Tatsuo Okui Yuki Kunisada Soichiro Ibaragi Hitoshi Nagatsuka Akira Sasaki Expression of Neurokinin B Receptor in the Gingival Squamous Cell Carcinoma Bone Microenvironment Diagnostics neurokinin B receptor gingival squamous cell carcinoma osteoclast |
| title | Expression of Neurokinin B Receptor in the Gingival Squamous Cell Carcinoma Bone Microenvironment |
| title_full | Expression of Neurokinin B Receptor in the Gingival Squamous Cell Carcinoma Bone Microenvironment |
| title_fullStr | Expression of Neurokinin B Receptor in the Gingival Squamous Cell Carcinoma Bone Microenvironment |
| title_full_unstemmed | Expression of Neurokinin B Receptor in the Gingival Squamous Cell Carcinoma Bone Microenvironment |
| title_short | Expression of Neurokinin B Receptor in the Gingival Squamous Cell Carcinoma Bone Microenvironment |
| title_sort | expression of neurokinin b receptor in the gingival squamous cell carcinoma bone microenvironment |
| topic | neurokinin B receptor gingival squamous cell carcinoma osteoclast |
| url | https://www.mdpi.com/2075-4418/11/6/1044 |
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