High-Fat Diet-Induced Obesity Model Does Not Promote Endothelial Dysfunction via Increasing Leptin/Akt/eNOS Signaling

High-Fat Diet-Induced Obesity Model Does Not Promote Endothelial Dysfunction via Increasing Leptin/Akt/eNOS Signaling

Experimental studies show that the unsaturated high-fat diet-induced obesity promotes vascular alterations characterized by improving the endothelial L-arginine/Nitric Oxide (NO) pathway. Leptin seems to be involved in this process, promoting vasodilation via increasing NO bioavailability. The aim o...

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Bibliographic Details
Main Authors: Vanessa da Silva Rocha, Erick Roberto Gonçalves Claudio, Vitor Loureiro da Silva, Jóctan Pimentel Cordeiro, Lucas Furtado Domingos, Márcia Regina Holanda da Cunha, Helder Mauad, Thiago Bruder do Nascimento, Ana Paula Lima-Leopoldo, André Soares Leopoldo
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-03-01
Series:Frontiers in Physiology
Subjects:
obesity
high-fat diet
leptin
Akt
vascular reactivity
Online Access:https://www.frontiersin.org/article/10.3389/fphys.2019.00268/full

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