Design, Synthesis, Molecular Docking, and Biological Evaluation of Pyrazole Hybrid Chalcone Conjugates as Potential Anticancer Agents and Tubulin Polymerization Inhibitors

Design, Synthesis, Molecular Docking, and Biological Evaluation of Pyrazole Hybrid Chalcone Conjugates as Potential Anticancer Agents and Tubulin Polymerization Inhibitors

Some (<i>E</i>)-3-(3-(4-(benzyloxy)phenyl)-1-phenyl-1<i>H</i>-pyrazol-4-yl)-1-phenylprop-2-en-1-one conjugates <b>5a</b>–<b>r</b> were designed; synthesized; characterized by <sup>1</sup>H, <sup>13</sup>C NMR, and ESI-MS; and ev...

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Bibliographic Details
Main Authors: Md. Jahangir Alam, Ozair Alam, Ahmad Perwez, Moshahid Alam Rizvi, Mohd Javed Naim, Vegi G. M. Naidu, Mohd Imran, Mohammed M. Ghoneim, Sultan Alshehri, Faiyaz Shakeel
Format: Article
Language:English
Published: MDPI AG 2022-02-01
Series:Pharmaceuticals
Subjects:
pyrazole conjugate
anticancer
MTT assay
molecular docking
cytotoxicity
tubulin polymerization inhibitors
Online Access:https://www.mdpi.com/1424-8247/15/3/280

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