Continuous Renal Replacement Therapy: A Review of Use and Application in Pediatric Hematopoietic Stem Cell Transplant Recipients
Hematopoietic stem cell transplant (HSCT) is a curative therapy for malignant and non-malignant conditions. However, complications post-HSCT contribute to significant morbidity and mortality in this population. Acute kidney injury (AKI) is common in the post-allogeneic transplant phase and contribut...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-02-01
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| Series: | Frontiers in Oncology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2021.632263/full |
| _version_ | 1819175579263434752 |
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| author | Lama Elbahlawan John Bissler John Bissler R. Ray Morrison |
| author_facet | Lama Elbahlawan John Bissler John Bissler R. Ray Morrison |
| author_sort | Lama Elbahlawan |
| collection | DOAJ |
| description | Hematopoietic stem cell transplant (HSCT) is a curative therapy for malignant and non-malignant conditions. However, complications post-HSCT contribute to significant morbidity and mortality in this population. Acute kidney injury (AKI) is common in the post-allogeneic transplant phase and contributes to morbidity in this population. Continuous renal replacement therapy (CRRT) is used often in the setting of AKI or multiorgan dysfunction in critically ill children. In addition, CRRT can be useful in many disease processes related to transplant and can potentially improve outcomes in this population. This review will focus on the use of CRRT in critically ill children in the post-HSCT setting outside the realm of acute renal failure and highlight the benefits and applications of this modality in this high-risk population. |
| first_indexed | 2024-12-22T20:57:06Z |
| format | Article |
| id | doaj.art-2f2b957b9935481f873c28a1c9943a90 |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-12-22T20:57:06Z |
| publishDate | 2021-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-2f2b957b9935481f873c28a1c9943a902022-12-21T18:12:56ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2021-02-011110.3389/fonc.2021.632263632263Continuous Renal Replacement Therapy: A Review of Use and Application in Pediatric Hematopoietic Stem Cell Transplant RecipientsLama Elbahlawan0John Bissler1John Bissler2R. Ray Morrison3Division of Critical Care Medicine, St. Jude Children’s Research Hospital, Memphis, TN, United StatesDepartment of Pediatrics, University of Tennessee Health Science Center and Le Bonheur Children’s Hospital, Memphis, TN, United StatesDepartment of Pediatrics, St. Jude Children’s Research Hospital, Memphis, TN, United StatesDivision of Critical Care Medicine, St. Jude Children’s Research Hospital, Memphis, TN, United StatesHematopoietic stem cell transplant (HSCT) is a curative therapy for malignant and non-malignant conditions. However, complications post-HSCT contribute to significant morbidity and mortality in this population. Acute kidney injury (AKI) is common in the post-allogeneic transplant phase and contributes to morbidity in this population. Continuous renal replacement therapy (CRRT) is used often in the setting of AKI or multiorgan dysfunction in critically ill children. In addition, CRRT can be useful in many disease processes related to transplant and can potentially improve outcomes in this population. This review will focus on the use of CRRT in critically ill children in the post-HSCT setting outside the realm of acute renal failure and highlight the benefits and applications of this modality in this high-risk population.https://www.frontiersin.org/articles/10.3389/fonc.2021.632263/fullcontinuous renal replacement therapy (CRRT)renal replacement therapyhematopoietic (stem) cell transplantation (HCST)fluid overloadpediatricsoutcome |
| spellingShingle | Lama Elbahlawan John Bissler John Bissler R. Ray Morrison Continuous Renal Replacement Therapy: A Review of Use and Application in Pediatric Hematopoietic Stem Cell Transplant Recipients Frontiers in Oncology continuous renal replacement therapy (CRRT) renal replacement therapy hematopoietic (stem) cell transplantation (HCST) fluid overload pediatrics outcome |
| title | Continuous Renal Replacement Therapy: A Review of Use and Application in Pediatric Hematopoietic Stem Cell Transplant Recipients |
| title_full | Continuous Renal Replacement Therapy: A Review of Use and Application in Pediatric Hematopoietic Stem Cell Transplant Recipients |
| title_fullStr | Continuous Renal Replacement Therapy: A Review of Use and Application in Pediatric Hematopoietic Stem Cell Transplant Recipients |
| title_full_unstemmed | Continuous Renal Replacement Therapy: A Review of Use and Application in Pediatric Hematopoietic Stem Cell Transplant Recipients |
| title_short | Continuous Renal Replacement Therapy: A Review of Use and Application in Pediatric Hematopoietic Stem Cell Transplant Recipients |
| title_sort | continuous renal replacement therapy a review of use and application in pediatric hematopoietic stem cell transplant recipients |
| topic | continuous renal replacement therapy (CRRT) renal replacement therapy hematopoietic (stem) cell transplantation (HCST) fluid overload pediatrics outcome |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2021.632263/full |
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