Intravascular Large B-Cell Lymphoma Presenting As Thyroid, Adrenal And Mesenteric Nodules
ABSTRACT: Objective: Identification of multiple endocrine abnormalities can result from endocrine or nonendocrine malignancies, genetic syndromes, or systemic diseases. Here, we evaluate an unusual presentation of several endocrine pathologies.Methods: We present a female with multiple endocrine abn...
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| Format: | Article |
| Language: | English |
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Elsevier
2017-01-01
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| Series: | AACE Clinical Case Reports |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S237606052030198X |
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| author | Priya H. Dedhia, MD, PhD Kerri Lopez, BS Anupama Reddy, DO Jonathan B. McHugh, MD Eric Langer, DO Barbra S. Miller, MD |
| author_facet | Priya H. Dedhia, MD, PhD Kerri Lopez, BS Anupama Reddy, DO Jonathan B. McHugh, MD Eric Langer, DO Barbra S. Miller, MD |
| author_sort | Priya H. Dedhia, MD, PhD |
| collection | DOAJ |
| description | ABSTRACT: Objective: Identification of multiple endocrine abnormalities can result from endocrine or nonendocrine malignancies, genetic syndromes, or systemic diseases. Here, we evaluate an unusual presentation of several endocrine pathologies.Methods: We present a female with multiple endocrine abnormalities who was ultimately diagnosed with intravascular large B-cell lymphoma (IVLBCL). We also review the literature on IVLBCL, including presentation, management, treatment, and outcomes.Results: A 52-year-old woman with multinodular goiter presented with an enlarging thyroid nodule. Fine needle aspiration revealed a high-grade neoplasm of unclear etiology. Due to a history of nephrolithiasis, the patient was also evaluated for and found to have probable primary hyperparathyroidism. Magnetic resonance imaging performed for lumbar pain identified an incidental indeterminate 2.7-cm nonfunctioning adrenal nodule. [18F]-fluorodeoxyglucose (FDG) positron emission tomography–computed tomography (PET-CT) demonstrated an FDG-avid adrenal nodule and an additional mesenteric nodule with standardized uptake values of 12.8 and 11.9, respectively. The thyroid gland showed no clear focus of FDG uptake. She underwent total thyroidectomy, limited central neck dissection, and excision of an enlarged hypercellular parathyroid gland. Final pathology revealed the rare diagnosis of diffuse IVLBCL coursing throughout the vasculature of the thyroid, including an otherwise benign thyroid nodule. The patient received rituximab-cyclophosphamide-doxorubicin-vincristine-prednisone chemotherapy with intrathecal methotrexate postoperatively. Post-chemotherapy PET-CT documented resolution of the adrenal and mesenteric nodules. This is a rare case of IVLBCL presenting in the background of an enlarging thyroid nodule and a multinodular goiter.Conclusion: Pathology involving multiple endocrine organs necessitates careful evaluation and management with consideration for syndromal or other systemic disorders.Abbreviations: CNS = central nervous system; FDG = [18F]-fluorodeoxyglucose; IVLBCL = intravascular large B-cell lymphoma; PET-CT = positron emission tomography–computed tomography; R-CHOP = rituximab-cyclophosphamide-doxorubicin-vincristineprednisone |
| first_indexed | 2024-12-21T10:17:54Z |
| format | Article |
| id | doaj.art-2f2bbd1a35604c0d969228a112951f77 |
| institution | Directory Open Access Journal |
| issn | 2376-0605 |
| language | English |
| last_indexed | 2024-12-21T10:17:54Z |
| publishDate | 2017-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | AACE Clinical Case Reports |
| spelling | doaj.art-2f2bbd1a35604c0d969228a112951f772022-12-21T19:07:32ZengElsevierAACE Clinical Case Reports2376-06052017-01-0132e106e110Intravascular Large B-Cell Lymphoma Presenting As Thyroid, Adrenal And Mesenteric NodulesPriya H. Dedhia, MD, PhD0Kerri Lopez, BS1Anupama Reddy, DO2Jonathan B. McHugh, MD3Eric Langer, DO4Barbra S. Miller, MD5From the 1Division of Endocrine Surgery, Department of Surgery, University of Michigan, Ann Arbor, Michigan; Address correspondence to Dr. Priya H. Dedhia, Section of General Surgery, 2110 Taubman Center, SPC 5346, 1500 East Medical Center Drive, Ann Arbor, MI 48109. E-mail:From the 1Division of Endocrine Surgery, Department of Surgery, University of Michigan, Ann Arbor, MichiganTri-County Endocrinology and Nuclear Medicine, McLaren Health Care, Sterling Heights, MichiganDivision of Anatomic Pathology, Department of Pathology, University of Michigan, Ann Arbor, Michigan.Tri-County Endocrinology and Nuclear Medicine, McLaren Health Care, Sterling Heights, MichiganFrom the 1Division of Endocrine Surgery, Department of Surgery, University of Michigan, Ann Arbor, MichiganABSTRACT: Objective: Identification of multiple endocrine abnormalities can result from endocrine or nonendocrine malignancies, genetic syndromes, or systemic diseases. Here, we evaluate an unusual presentation of several endocrine pathologies.Methods: We present a female with multiple endocrine abnormalities who was ultimately diagnosed with intravascular large B-cell lymphoma (IVLBCL). We also review the literature on IVLBCL, including presentation, management, treatment, and outcomes.Results: A 52-year-old woman with multinodular goiter presented with an enlarging thyroid nodule. Fine needle aspiration revealed a high-grade neoplasm of unclear etiology. Due to a history of nephrolithiasis, the patient was also evaluated for and found to have probable primary hyperparathyroidism. Magnetic resonance imaging performed for lumbar pain identified an incidental indeterminate 2.7-cm nonfunctioning adrenal nodule. [18F]-fluorodeoxyglucose (FDG) positron emission tomography–computed tomography (PET-CT) demonstrated an FDG-avid adrenal nodule and an additional mesenteric nodule with standardized uptake values of 12.8 and 11.9, respectively. The thyroid gland showed no clear focus of FDG uptake. She underwent total thyroidectomy, limited central neck dissection, and excision of an enlarged hypercellular parathyroid gland. Final pathology revealed the rare diagnosis of diffuse IVLBCL coursing throughout the vasculature of the thyroid, including an otherwise benign thyroid nodule. The patient received rituximab-cyclophosphamide-doxorubicin-vincristine-prednisone chemotherapy with intrathecal methotrexate postoperatively. Post-chemotherapy PET-CT documented resolution of the adrenal and mesenteric nodules. This is a rare case of IVLBCL presenting in the background of an enlarging thyroid nodule and a multinodular goiter.Conclusion: Pathology involving multiple endocrine organs necessitates careful evaluation and management with consideration for syndromal or other systemic disorders.Abbreviations: CNS = central nervous system; FDG = [18F]-fluorodeoxyglucose; IVLBCL = intravascular large B-cell lymphoma; PET-CT = positron emission tomography–computed tomography; R-CHOP = rituximab-cyclophosphamide-doxorubicin-vincristineprednisonehttp://www.sciencedirect.com/science/article/pii/S237606052030198X |
| spellingShingle | Priya H. Dedhia, MD, PhD Kerri Lopez, BS Anupama Reddy, DO Jonathan B. McHugh, MD Eric Langer, DO Barbra S. Miller, MD Intravascular Large B-Cell Lymphoma Presenting As Thyroid, Adrenal And Mesenteric Nodules AACE Clinical Case Reports |
| title | Intravascular Large B-Cell Lymphoma Presenting As Thyroid, Adrenal And Mesenteric Nodules |
| title_full | Intravascular Large B-Cell Lymphoma Presenting As Thyroid, Adrenal And Mesenteric Nodules |
| title_fullStr | Intravascular Large B-Cell Lymphoma Presenting As Thyroid, Adrenal And Mesenteric Nodules |
| title_full_unstemmed | Intravascular Large B-Cell Lymphoma Presenting As Thyroid, Adrenal And Mesenteric Nodules |
| title_short | Intravascular Large B-Cell Lymphoma Presenting As Thyroid, Adrenal And Mesenteric Nodules |
| title_sort | intravascular large b cell lymphoma presenting as thyroid adrenal and mesenteric nodules |
| url | http://www.sciencedirect.com/science/article/pii/S237606052030198X |
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