The impact of Angiopoietin-2 genetic polymorphisms on susceptibility for malignant breast neoplasms
Abstract Breast cancer causes morbidity and mortality among women worldwide, despite much research illuminating the genetic basis of this disease. Anti-angiogenesis therapies have been widely studied, although the association between angiopoietin-2 (ANGPT2) single nucleotide polymorphisms (SNPs) and...
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| Format: | Article |
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Nature Portfolio
2022-08-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-022-18712-9 |
| _version_ | 1811188863621660672 |
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| author | Gui-Nv Hu Yan Wang Chih-Hsin Tang Lu-Lu Jin Bi-Fei Huang Qian Wang Jun-Kang Shao Chao-Qun Wang Chen-Ming Su |
| author_facet | Gui-Nv Hu Yan Wang Chih-Hsin Tang Lu-Lu Jin Bi-Fei Huang Qian Wang Jun-Kang Shao Chao-Qun Wang Chen-Ming Su |
| author_sort | Gui-Nv Hu |
| collection | DOAJ |
| description | Abstract Breast cancer causes morbidity and mortality among women worldwide, despite much research illuminating the genetic basis of this disease. Anti-angiogenesis therapies have been widely studied, although the association between angiopoietin-2 (ANGPT2) single nucleotide polymorphisms (SNPs) and breast cancer subtypes remains unclear. This case–control study included 464 patients with malignant breast neoplasms and 539 cancer-free females. We explored the effects of ANGPT2 SNPs on the susceptibility for a malignant breast neoplasm in a Chinese Han population. Five ANGPT2 SNPs (rs2442598, rs734701, rs1823375, 11,137,037, and rs12674822) were analyzed using TaqMan SNP genotyping. Carriers of the variant GG allele of rs1823375 were less likely than wild-type carriers to be diagnosed with clinically staged breast cancer, while females with human epidermal growth factor receptor 2 (HER2)-enriched disease carrying the CG or the CG+GG genotype at rs1823375 were significantly less likely than CC genotype carriers to be of lymph node status N1–N3. We also found that the T-T-C-A-T ANGPT2 haplotype significantly increased the risk for developing a malignant breast neoplasm by 1.385-fold (95% CI: 1.025–1.871; p < 0.05). Our study is the first to document a correlation between ANGPT2 polymorphisms and the development and progression of a malignant breast neoplasm in females of Chinese Han ethnicity. |
| first_indexed | 2024-04-11T14:25:16Z |
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| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-04-11T14:25:16Z |
| publishDate | 2022-08-01 |
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| series | Scientific Reports |
| spelling | doaj.art-2f2fca65f7bc49418ac99e721c5f846f2022-12-22T04:18:53ZengNature PortfolioScientific Reports2045-23222022-08-0112111010.1038/s41598-022-18712-9The impact of Angiopoietin-2 genetic polymorphisms on susceptibility for malignant breast neoplasmsGui-Nv Hu0Yan Wang1Chih-Hsin Tang2Lu-Lu Jin3Bi-Fei Huang4Qian Wang5Jun-Kang Shao6Chao-Qun Wang7Chen-Ming Su8Department of Surgical Oncology, Affiliated Dongyang Hospital of Wenzhou Medical UniversityDepartment of Medical Oncology, Affiliated Dongyang Hospital of Wenzhou Medical UniversityDepartment of Pharmacology, School of Medicine, China Medical UniversityDepartment of Biomedical Sciences Laboratory, Affiliated Dongyang Hospital of Wenzhou Medical UniversityDepartment of Pathology, Affiliated Dongyang Hospital of Wenzhou Medical UniversityDepartment of Pathology, Affiliated Dongyang Hospital of Wenzhou Medical UniversityDepartment of Pathology, Affiliated Dongyang Hospital of Wenzhou Medical UniversityDepartment of Pathology, Affiliated Dongyang Hospital of Wenzhou Medical UniversityDepartment of Sports Medicine, China Medical UniversityAbstract Breast cancer causes morbidity and mortality among women worldwide, despite much research illuminating the genetic basis of this disease. Anti-angiogenesis therapies have been widely studied, although the association between angiopoietin-2 (ANGPT2) single nucleotide polymorphisms (SNPs) and breast cancer subtypes remains unclear. This case–control study included 464 patients with malignant breast neoplasms and 539 cancer-free females. We explored the effects of ANGPT2 SNPs on the susceptibility for a malignant breast neoplasm in a Chinese Han population. Five ANGPT2 SNPs (rs2442598, rs734701, rs1823375, 11,137,037, and rs12674822) were analyzed using TaqMan SNP genotyping. Carriers of the variant GG allele of rs1823375 were less likely than wild-type carriers to be diagnosed with clinically staged breast cancer, while females with human epidermal growth factor receptor 2 (HER2)-enriched disease carrying the CG or the CG+GG genotype at rs1823375 were significantly less likely than CC genotype carriers to be of lymph node status N1–N3. We also found that the T-T-C-A-T ANGPT2 haplotype significantly increased the risk for developing a malignant breast neoplasm by 1.385-fold (95% CI: 1.025–1.871; p < 0.05). Our study is the first to document a correlation between ANGPT2 polymorphisms and the development and progression of a malignant breast neoplasm in females of Chinese Han ethnicity.https://doi.org/10.1038/s41598-022-18712-9 |
| spellingShingle | Gui-Nv Hu Yan Wang Chih-Hsin Tang Lu-Lu Jin Bi-Fei Huang Qian Wang Jun-Kang Shao Chao-Qun Wang Chen-Ming Su The impact of Angiopoietin-2 genetic polymorphisms on susceptibility for malignant breast neoplasms Scientific Reports |
| title | The impact of Angiopoietin-2 genetic polymorphisms on susceptibility for malignant breast neoplasms |
| title_full | The impact of Angiopoietin-2 genetic polymorphisms on susceptibility for malignant breast neoplasms |
| title_fullStr | The impact of Angiopoietin-2 genetic polymorphisms on susceptibility for malignant breast neoplasms |
| title_full_unstemmed | The impact of Angiopoietin-2 genetic polymorphisms on susceptibility for malignant breast neoplasms |
| title_short | The impact of Angiopoietin-2 genetic polymorphisms on susceptibility for malignant breast neoplasms |
| title_sort | impact of angiopoietin 2 genetic polymorphisms on susceptibility for malignant breast neoplasms |
| url | https://doi.org/10.1038/s41598-022-18712-9 |
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