Cellular Senescence and Ageing: Mechanisms and Interventions
The influence of the activation of a cellular phenotype termed senescence and it’s importance in ageing and age-related diseases is becoming more and more evident. In fact, there is a huge effort to tackle these diseases via therapeutic drugs targeting senescent cells named senolytics. However, a cl...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2022-03-01
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| Series: | Frontiers in Aging |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fragi.2022.866718/full |
| _version_ | 1811329439711100928 |
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| author | Andreas Mylonas Ana O’Loghlen |
| author_facet | Andreas Mylonas Ana O’Loghlen |
| author_sort | Andreas Mylonas |
| collection | DOAJ |
| description | The influence of the activation of a cellular phenotype termed senescence and it’s importance in ageing and age-related diseases is becoming more and more evident. In fact, there is a huge effort to tackle these diseases via therapeutic drugs targeting senescent cells named senolytics. However, a clearer understanding of how senescence is activated and the influence it has on specific cellular types and tissues is needed. Here, we describe general triggers and characteristics of senescence. In addition, we describe the influence of senescent cells in ageing and different age-related diseases. |
| first_indexed | 2024-04-13T15:45:08Z |
| format | Article |
| id | doaj.art-2f30eda9444a4de284f7d8ed7174cf36 |
| institution | Directory Open Access Journal |
| issn | 2673-6217 |
| language | English |
| last_indexed | 2024-04-13T15:45:08Z |
| publishDate | 2022-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Aging |
| spelling | doaj.art-2f30eda9444a4de284f7d8ed7174cf362022-12-22T02:41:01ZengFrontiers Media S.A.Frontiers in Aging2673-62172022-03-01310.3389/fragi.2022.866718866718Cellular Senescence and Ageing: Mechanisms and InterventionsAndreas MylonasAna O’LoghlenThe influence of the activation of a cellular phenotype termed senescence and it’s importance in ageing and age-related diseases is becoming more and more evident. In fact, there is a huge effort to tackle these diseases via therapeutic drugs targeting senescent cells named senolytics. However, a clearer understanding of how senescence is activated and the influence it has on specific cellular types and tissues is needed. Here, we describe general triggers and characteristics of senescence. In addition, we describe the influence of senescent cells in ageing and different age-related diseases.https://www.frontiersin.org/articles/10.3389/fragi.2022.866718/fullsenescenceageingSASPage-related diseasehallmarkssenolytics |
| spellingShingle | Andreas Mylonas Ana O’Loghlen Cellular Senescence and Ageing: Mechanisms and Interventions Frontiers in Aging senescence ageing SASP age-related disease hallmarks senolytics |
| title | Cellular Senescence and Ageing: Mechanisms and Interventions |
| title_full | Cellular Senescence and Ageing: Mechanisms and Interventions |
| title_fullStr | Cellular Senescence and Ageing: Mechanisms and Interventions |
| title_full_unstemmed | Cellular Senescence and Ageing: Mechanisms and Interventions |
| title_short | Cellular Senescence and Ageing: Mechanisms and Interventions |
| title_sort | cellular senescence and ageing mechanisms and interventions |
| topic | senescence ageing SASP age-related disease hallmarks senolytics |
| url | https://www.frontiersin.org/articles/10.3389/fragi.2022.866718/full |
| work_keys_str_mv | AT andreasmylonas cellularsenescenceandageingmechanismsandinterventions AT anaologhlen cellularsenescenceandageingmechanismsandinterventions |