Protective effect of interferon-based antiviral therapy on risk of bipolar disorder in patients with hepatitis C Virus infection: A nationwide longitudinal study
Background: A recent study has shown the beneficial effects of interferon (IFN)-based antiviral therapy (AVT) in reducing the risk of newly diagnosed depression among patients with hepatitis C virus (HCV) infection. But whether IFN-based AVT reduces the risk of bipolar disorder remains unknown. Meth...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2022-01-01
|
| Series: | Taiwanese Journal of Psychiatry |
| Subjects: | |
| Online Access: | http://www.e-tjp.org/article.asp?issn=1028-3684;year=2022;volume=36;issue=4;spage=182;epage=187;aulast=Chen |
| _version_ | 1828065922892431360 |
|---|---|
| author | Mu- Hong Chen Shih- Jen Tsai Tzeng- Ji Chen |
| author_facet | Mu- Hong Chen Shih- Jen Tsai Tzeng- Ji Chen |
| author_sort | Mu- Hong Chen |
| collection | DOAJ |
| description | Background: A recent study has shown the beneficial effects of interferon (IFN)-based antiviral therapy (AVT) in reducing the risk of newly diagnosed depression among patients with hepatitis C virus (HCV) infection. But whether IFN-based AVT reduces the risk of bipolar disorder remains unknown. Methods: This is a retrospective study based on the Taiwan National Health Insurance Research Database. From enrollment to the end of 2013, 24,240 patients with HCV infection (4473 treated with IFN-based AVT and 19,767 without such treatment) as well as 96,960 age- and sex-matched controls were included in this study. Time-dependent Cox regression models were used to study the differences in risk of newly-diagnosed bipolar disorder between patients being treated with and without IFN-based AVT and the control participants. Results: Patients with HCV infection who had not yet received IFN-based AVT (hazard ratio = 4.86, 95% confidence interval = 1.87–12.66, p = 0.001), but not those who were receiving IFN-based AVT (1.69, 0.94 - 30.50, nonsignificance) and those who completed the IFN-based AVT (1.77, 0.69 - 4.54, nonsignificance), were significantly more to be diagnosed with bipolar disorder compared with the control group. Conclusion: Our study supports the temporal association between HCV infection and subsequent bipolar disorder, further suggesting that the optimal AVT to eradicate HCV may be associated with a reduced risk of incident bipolar disorder later in life. |
| first_indexed | 2024-04-10T23:21:47Z |
| format | Article |
| id | doaj.art-2f319f3534c44c3387f6f79b1800c05f |
| institution | Directory Open Access Journal |
| issn | 1028-3684 2666-2078 |
| language | English |
| last_indexed | 2024-04-10T23:21:47Z |
| publishDate | 2022-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Taiwanese Journal of Psychiatry |
| spelling | doaj.art-2f319f3534c44c3387f6f79b1800c05f2023-01-12T13:42:19ZengWolters Kluwer Medknow PublicationsTaiwanese Journal of Psychiatry1028-36842666-20782022-01-0136418218710.4103/TPSY.TPSY_37_22Protective effect of interferon-based antiviral therapy on risk of bipolar disorder in patients with hepatitis C Virus infection: A nationwide longitudinal studyMu- Hong ChenShih- Jen TsaiTzeng- Ji ChenBackground: A recent study has shown the beneficial effects of interferon (IFN)-based antiviral therapy (AVT) in reducing the risk of newly diagnosed depression among patients with hepatitis C virus (HCV) infection. But whether IFN-based AVT reduces the risk of bipolar disorder remains unknown. Methods: This is a retrospective study based on the Taiwan National Health Insurance Research Database. From enrollment to the end of 2013, 24,240 patients with HCV infection (4473 treated with IFN-based AVT and 19,767 without such treatment) as well as 96,960 age- and sex-matched controls were included in this study. Time-dependent Cox regression models were used to study the differences in risk of newly-diagnosed bipolar disorder between patients being treated with and without IFN-based AVT and the control participants. Results: Patients with HCV infection who had not yet received IFN-based AVT (hazard ratio = 4.86, 95% confidence interval = 1.87–12.66, p = 0.001), but not those who were receiving IFN-based AVT (1.69, 0.94 - 30.50, nonsignificance) and those who completed the IFN-based AVT (1.77, 0.69 - 4.54, nonsignificance), were significantly more to be diagnosed with bipolar disorder compared with the control group. Conclusion: Our study supports the temporal association between HCV infection and subsequent bipolar disorder, further suggesting that the optimal AVT to eradicate HCV may be associated with a reduced risk of incident bipolar disorder later in life.http://www.e-tjp.org/article.asp?issn=1028-3684;year=2022;volume=36;issue=4;spage=182;epage=187;aulast=Chendepressioninflammationtemporal associationthe taiwan national health insurance research database |
| spellingShingle | Mu- Hong Chen Shih- Jen Tsai Tzeng- Ji Chen Protective effect of interferon-based antiviral therapy on risk of bipolar disorder in patients with hepatitis C Virus infection: A nationwide longitudinal study Taiwanese Journal of Psychiatry depression inflammation temporal association the taiwan national health insurance research database |
| title | Protective effect of interferon-based antiviral therapy on risk of bipolar disorder in patients with hepatitis C Virus infection: A nationwide longitudinal study |
| title_full | Protective effect of interferon-based antiviral therapy on risk of bipolar disorder in patients with hepatitis C Virus infection: A nationwide longitudinal study |
| title_fullStr | Protective effect of interferon-based antiviral therapy on risk of bipolar disorder in patients with hepatitis C Virus infection: A nationwide longitudinal study |
| title_full_unstemmed | Protective effect of interferon-based antiviral therapy on risk of bipolar disorder in patients with hepatitis C Virus infection: A nationwide longitudinal study |
| title_short | Protective effect of interferon-based antiviral therapy on risk of bipolar disorder in patients with hepatitis C Virus infection: A nationwide longitudinal study |
| title_sort | protective effect of interferon based antiviral therapy on risk of bipolar disorder in patients with hepatitis c virus infection a nationwide longitudinal study |
| topic | depression inflammation temporal association the taiwan national health insurance research database |
| url | http://www.e-tjp.org/article.asp?issn=1028-3684;year=2022;volume=36;issue=4;spage=182;epage=187;aulast=Chen |
| work_keys_str_mv | AT muhongchen protectiveeffectofinterferonbasedantiviraltherapyonriskofbipolardisorderinpatientswithhepatitiscvirusinfectionanationwidelongitudinalstudy AT shihjentsai protectiveeffectofinterferonbasedantiviraltherapyonriskofbipolardisorderinpatientswithhepatitiscvirusinfectionanationwidelongitudinalstudy AT tzengjichen protectiveeffectofinterferonbasedantiviraltherapyonriskofbipolardisorderinpatientswithhepatitiscvirusinfectionanationwidelongitudinalstudy |