EHMT2 methyltransferase governs cell identity in the lung and is required for KRAS G12D tumor development and propagation

EHMT2 methyltransferase governs cell identity in the lung and is required for KRAS G12D tumor development and propagation

Lung development, integrity and repair rely on precise Wnt signaling, which is corrupted in diverse diseases, including cancer. Here, we discover that EHMT2 methyltransferase regulates Wnt signaling in the lung by controlling the transcriptional activity of chromatin-bound β-catenin, through a non-h...

Full description

Bibliographic Details
Main Authors: Ariel Pribluda, Anneleen Daemen, Anthony Nelson Lima, Xi Wang, Marc Hafner, Chungkee Poon, Zora Modrusan, Anand Kumar Katakam, Oded Foreman, Jefferey Eastham, Jefferey Hung, Benjamin Haley, Julia T Garcia, Erica L Jackson, Melissa R Junttila
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2022-08-01
Series:eLife
Subjects:
lung
Wnt
cancer
AT2
G9a
Ehmt2
Online Access:https://elifesciences.org/articles/57648

Internet

https://elifesciences.org/articles/57648

Similar Items