High fat diet induces obesity, alters eating pattern and disrupts corticosterone circadian rhythms in female ICR mice.
Circadian, metabolic, and reproductive systems are inter-regulated. Excessive fatness and circadian disruption alter normal physiology and the endocrine milieu, including cortisol, the primary stress hormone. Our aim was to determine the effect feeding a high fat diet to female ICR mice had on diurn...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2023-01-01
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| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0279209 |
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| author | Kelsey Teeple Prabha Rajput Maria Gonzalez Yu Han-Hallett Esteban Fernández-Juricic Theresa Casey |
| author_facet | Kelsey Teeple Prabha Rajput Maria Gonzalez Yu Han-Hallett Esteban Fernández-Juricic Theresa Casey |
| author_sort | Kelsey Teeple |
| collection | DOAJ |
| description | Circadian, metabolic, and reproductive systems are inter-regulated. Excessive fatness and circadian disruption alter normal physiology and the endocrine milieu, including cortisol, the primary stress hormone. Our aim was to determine the effect feeding a high fat diet to female ICR mice had on diurnal feeding pattern, weight gain, body composition, hair corticosterone levels and circadian patterns of fecal corticosterone. Prepubertal (~35d of age) ICR mice were assigned to control (CON; 10% fat) or high fat (HF; 60% fat) diet and fed for 4 wk to achieve obesity under 12h light and 12h of dark. Feed intake was measured twice daily to determine diurnal intake. Mice were weighed weekly. After 4 wk on diets hair was collected to measure corticosterone, crown-rump length was measured to calculate body mass index (BMI), and body composition was measured with EchoMRI to determine percent fat. HF mice weighed more (P<0.05) after week two, BMI and percent body fat was greater (P<0.05) in HF than CON at the end of wk 4. HF mice consumed more during the day (P<0.05) than CON mice after 1 week on diets. Hair corticosterone was higher in HF mice than in CON (P<0.05). Fecal circadian sampling over 48hr demonstrated that HF mice had elevated basal corticosterone, attenuated circadian rhythms, and a shift in amplitude. High fat feeding for diet induced obesity alters circadian eating pattern and corticosterone rhythms, indicating a need to consider the impact of circadian system disruption on reproductive competence. |
| first_indexed | 2024-04-10T20:15:21Z |
| format | Article |
| id | doaj.art-2f34263f01224028a7ff46ea9dcebf5e |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-04-10T20:15:21Z |
| publishDate | 2023-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-2f34263f01224028a7ff46ea9dcebf5e2023-01-26T05:32:11ZengPublic Library of Science (PLoS)PLoS ONE1932-62032023-01-01181e027920910.1371/journal.pone.0279209High fat diet induces obesity, alters eating pattern and disrupts corticosterone circadian rhythms in female ICR mice.Kelsey TeeplePrabha RajputMaria GonzalezYu Han-HallettEsteban Fernández-JuricicTheresa CaseyCircadian, metabolic, and reproductive systems are inter-regulated. Excessive fatness and circadian disruption alter normal physiology and the endocrine milieu, including cortisol, the primary stress hormone. Our aim was to determine the effect feeding a high fat diet to female ICR mice had on diurnal feeding pattern, weight gain, body composition, hair corticosterone levels and circadian patterns of fecal corticosterone. Prepubertal (~35d of age) ICR mice were assigned to control (CON; 10% fat) or high fat (HF; 60% fat) diet and fed for 4 wk to achieve obesity under 12h light and 12h of dark. Feed intake was measured twice daily to determine diurnal intake. Mice were weighed weekly. After 4 wk on diets hair was collected to measure corticosterone, crown-rump length was measured to calculate body mass index (BMI), and body composition was measured with EchoMRI to determine percent fat. HF mice weighed more (P<0.05) after week two, BMI and percent body fat was greater (P<0.05) in HF than CON at the end of wk 4. HF mice consumed more during the day (P<0.05) than CON mice after 1 week on diets. Hair corticosterone was higher in HF mice than in CON (P<0.05). Fecal circadian sampling over 48hr demonstrated that HF mice had elevated basal corticosterone, attenuated circadian rhythms, and a shift in amplitude. High fat feeding for diet induced obesity alters circadian eating pattern and corticosterone rhythms, indicating a need to consider the impact of circadian system disruption on reproductive competence.https://doi.org/10.1371/journal.pone.0279209 |
| spellingShingle | Kelsey Teeple Prabha Rajput Maria Gonzalez Yu Han-Hallett Esteban Fernández-Juricic Theresa Casey High fat diet induces obesity, alters eating pattern and disrupts corticosterone circadian rhythms in female ICR mice. PLoS ONE |
| title | High fat diet induces obesity, alters eating pattern and disrupts corticosterone circadian rhythms in female ICR mice. |
| title_full | High fat diet induces obesity, alters eating pattern and disrupts corticosterone circadian rhythms in female ICR mice. |
| title_fullStr | High fat diet induces obesity, alters eating pattern and disrupts corticosterone circadian rhythms in female ICR mice. |
| title_full_unstemmed | High fat diet induces obesity, alters eating pattern and disrupts corticosterone circadian rhythms in female ICR mice. |
| title_short | High fat diet induces obesity, alters eating pattern and disrupts corticosterone circadian rhythms in female ICR mice. |
| title_sort | high fat diet induces obesity alters eating pattern and disrupts corticosterone circadian rhythms in female icr mice |
| url | https://doi.org/10.1371/journal.pone.0279209 |
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