The Application of Mesenchymal Stromal Cells and Their Homing Capabilities to Regenerate the Intervertebral Disc
Chronic low back pain (LBP) remains a challenging condition to treat, and especially to cure. If conservative treatment approaches fail, the current “gold standard” for intervertebral disc degeneration (IDD)-provoked back pain is spinal fusion. However, due to its invasive and destructive nature, th...
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| Format: | Article |
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MDPI AG
2021-03-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/22/7/3519 |
| _version_ | 1797539667282755584 |
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| author | Andreas S. Croft Svenja Illien-Jünger Sibylle Grad Julien Guerrero Sebastian Wangler Benjamin Gantenbein |
| author_facet | Andreas S. Croft Svenja Illien-Jünger Sibylle Grad Julien Guerrero Sebastian Wangler Benjamin Gantenbein |
| author_sort | Andreas S. Croft |
| collection | DOAJ |
| description | Chronic low back pain (LBP) remains a challenging condition to treat, and especially to cure. If conservative treatment approaches fail, the current “gold standard” for intervertebral disc degeneration (IDD)-provoked back pain is spinal fusion. However, due to its invasive and destructive nature, the focus of orthopedic research related to the intervertebral disc (IVD) has shifted more towards cell-based therapeutic approaches. They aim to reduce or even reverse the degenerative cascade by mimicking the human body’s physiological healing system. The implementation of progenitor and/or stem cells and, in particular, the delivery of mesenchymal stromal cells (MSCs) has revealed significant potential to cure the degenerated/injured IVD. Over the past decade, many research groups have invested efforts to find ways to utilize these cells as efficiently and sustainably as possible. This narrative literature review presents a summary of achievements made with the application of MSCs for the regeneration of the IVD in recent years, including their preclinical and clinical applications. Moreover, this review presents state-of-the-art strategies on how the homing capabilities of MSCs can be utilized to repair damaged or degenerated IVDs, as well as their current limitations and future perspectives. |
| first_indexed | 2024-03-10T12:49:08Z |
| format | Article |
| id | doaj.art-2f3462619e7545a0a9dd72642ab6ef89 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T12:49:08Z |
| publishDate | 2021-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-2f3462619e7545a0a9dd72642ab6ef892023-11-21T13:14:01ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-03-01227351910.3390/ijms22073519The Application of Mesenchymal Stromal Cells and Their Homing Capabilities to Regenerate the Intervertebral DiscAndreas S. Croft0Svenja Illien-Jünger1Sibylle Grad2Julien Guerrero3Sebastian Wangler4Benjamin Gantenbein5Tissue Engineering for Orthopaedics & Mechanobiology (TOM), The Department for BioMedical Research (DBMR) of the Faculty of Medicine of the University of Bern, University of Bern, CH-3008 Bern, SwitzerlandDepartment of Orthopaedics, Emory University School of Medicine, VAMC, 1670 Clairmont Rd, Decatur, GA 30033, USAAO Research Institute Davos, CH-7270 Davos, SwitzerlandTissue Engineering for Orthopaedics & Mechanobiology (TOM), The Department for BioMedical Research (DBMR) of the Faculty of Medicine of the University of Bern, University of Bern, CH-3008 Bern, SwitzerlandDepartment of Orthopaedic Surgery and Traumatology, Inselspital, Bern University Hospital, University of Bern, CH-3010, Bern, SwitzerlandTissue Engineering for Orthopaedics & Mechanobiology (TOM), The Department for BioMedical Research (DBMR) of the Faculty of Medicine of the University of Bern, University of Bern, CH-3008 Bern, SwitzerlandChronic low back pain (LBP) remains a challenging condition to treat, and especially to cure. If conservative treatment approaches fail, the current “gold standard” for intervertebral disc degeneration (IDD)-provoked back pain is spinal fusion. However, due to its invasive and destructive nature, the focus of orthopedic research related to the intervertebral disc (IVD) has shifted more towards cell-based therapeutic approaches. They aim to reduce or even reverse the degenerative cascade by mimicking the human body’s physiological healing system. The implementation of progenitor and/or stem cells and, in particular, the delivery of mesenchymal stromal cells (MSCs) has revealed significant potential to cure the degenerated/injured IVD. Over the past decade, many research groups have invested efforts to find ways to utilize these cells as efficiently and sustainably as possible. This narrative literature review presents a summary of achievements made with the application of MSCs for the regeneration of the IVD in recent years, including their preclinical and clinical applications. Moreover, this review presents state-of-the-art strategies on how the homing capabilities of MSCs can be utilized to repair damaged or degenerated IVDs, as well as their current limitations and future perspectives.https://www.mdpi.com/1422-0067/22/7/3519mesenchymal stromal cellshomingcell-based therapyintervertebral disc regeneration |
| spellingShingle | Andreas S. Croft Svenja Illien-Jünger Sibylle Grad Julien Guerrero Sebastian Wangler Benjamin Gantenbein The Application of Mesenchymal Stromal Cells and Their Homing Capabilities to Regenerate the Intervertebral Disc International Journal of Molecular Sciences mesenchymal stromal cells homing cell-based therapy intervertebral disc regeneration |
| title | The Application of Mesenchymal Stromal Cells and Their Homing Capabilities to Regenerate the Intervertebral Disc |
| title_full | The Application of Mesenchymal Stromal Cells and Their Homing Capabilities to Regenerate the Intervertebral Disc |
| title_fullStr | The Application of Mesenchymal Stromal Cells and Their Homing Capabilities to Regenerate the Intervertebral Disc |
| title_full_unstemmed | The Application of Mesenchymal Stromal Cells and Their Homing Capabilities to Regenerate the Intervertebral Disc |
| title_short | The Application of Mesenchymal Stromal Cells and Their Homing Capabilities to Regenerate the Intervertebral Disc |
| title_sort | application of mesenchymal stromal cells and their homing capabilities to regenerate the intervertebral disc |
| topic | mesenchymal stromal cells homing cell-based therapy intervertebral disc regeneration |
| url | https://www.mdpi.com/1422-0067/22/7/3519 |
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