Computationally Guided Design of Single-Chain Variable Fragment Improves Specificity of Chimeric Antigen Receptors

Computationally Guided Design of Single-Chain Variable Fragment Improves Specificity of Chimeric Antigen Receptors

Chimeric antigen receptor (CAR)-T cell-based immunotherapy of malignant disease relies on the specificity and association constant of single-chain variable fragments (scFvs). The latter are synthesized from parent antibodies by fusing their light (VL) and heavy (VH)-chain variable domains into a sin...

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Bibliographic Details
Main Authors: Andrey Krokhotin, Hongwei Du, Koichi Hirabayashi, Konstantin Popov, Tomohiro Kurokawa, Xinhui Wan, Soldano Ferrone, Gianpietro Dotti, Nikolay V. Dokholyan
Format: Article
Language:English
Published: Elsevier 2019-12-01
Series:Molecular Therapy: Oncolytics
Online Access:http://www.sciencedirect.com/science/article/pii/S2372770519300798

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