Mechanisms of exercise-induced preconditioning in skeletal muscles
Endurance exercise training promotes numerous biochemical adaptations within skeletal muscle fibers culminating into a phenotype that is safeguarded against numerous perils including doxorubicin-induced myopathy and inactivity-induced muscle atrophy. This exercise-induced protection of skeletal musc...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2020-08-01
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| Series: | Redox Biology |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213231720300707 |
| _version_ | 1819066747191296000 |
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| author | Scott K. Powers Matthew Bomkamp Mustafa Ozdemir Hayden Hyatt |
| author_facet | Scott K. Powers Matthew Bomkamp Mustafa Ozdemir Hayden Hyatt |
| author_sort | Scott K. Powers |
| collection | DOAJ |
| description | Endurance exercise training promotes numerous biochemical adaptations within skeletal muscle fibers culminating into a phenotype that is safeguarded against numerous perils including doxorubicin-induced myopathy and inactivity-induced muscle atrophy. This exercise-induced protection of skeletal muscle fibers is commonly termed “exercise preconditioning”. This review will discuss the biochemical mechanisms responsible for exercise-induced protection of skeletal muscle fibers against these harmful events. The first segment of this report highlights the evidence that endurance exercise training provides cytoprotection to skeletal muscle fibers against several potentially damaging insults. The second and third sections of the review will discuss the cellular adaptations responsible for exercise-induced protection of skeletal muscle fibers against doxorubicin-provoked damage and inactivity-induced fiber atrophy, respectively. Importantly, we also identify gaps in our understanding of exercise preconditioning in hopes of stimulating future research. |
| first_indexed | 2024-12-21T16:07:16Z |
| format | Article |
| id | doaj.art-2f34b0559a624b1a920ae0394ba6f098 |
| institution | Directory Open Access Journal |
| issn | 2213-2317 |
| language | English |
| last_indexed | 2024-12-21T16:07:16Z |
| publishDate | 2020-08-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Redox Biology |
| spelling | doaj.art-2f34b0559a624b1a920ae0394ba6f0982022-12-21T18:57:52ZengElsevierRedox Biology2213-23172020-08-0135101462Mechanisms of exercise-induced preconditioning in skeletal musclesScott K. Powers0Matthew Bomkamp1Mustafa Ozdemir2Hayden Hyatt3Department of Applied Physiology and Kinesiology, University of Florida, Gainesville, FL, 32611, USADepartment of Applied Physiology and Kinesiology, University of Florida, Gainesville, FL, 32611, USADepartment of Applied Physiology and Kinesiology, University of Florida, Gainesville, FL, 32611, USADepartment of Applied Physiology and Kinesiology, University of Florida, Gainesville, FL, 32611, USAEndurance exercise training promotes numerous biochemical adaptations within skeletal muscle fibers culminating into a phenotype that is safeguarded against numerous perils including doxorubicin-induced myopathy and inactivity-induced muscle atrophy. This exercise-induced protection of skeletal muscle fibers is commonly termed “exercise preconditioning”. This review will discuss the biochemical mechanisms responsible for exercise-induced protection of skeletal muscle fibers against these harmful events. The first segment of this report highlights the evidence that endurance exercise training provides cytoprotection to skeletal muscle fibers against several potentially damaging insults. The second and third sections of the review will discuss the cellular adaptations responsible for exercise-induced protection of skeletal muscle fibers against doxorubicin-provoked damage and inactivity-induced fiber atrophy, respectively. Importantly, we also identify gaps in our understanding of exercise preconditioning in hopes of stimulating future research.http://www.sciencedirect.com/science/article/pii/S2213231720300707DoxorubicinEndurance exerciseDiaphragmMechanical ventilationMuscle atrophyHeart |
| spellingShingle | Scott K. Powers Matthew Bomkamp Mustafa Ozdemir Hayden Hyatt Mechanisms of exercise-induced preconditioning in skeletal muscles Redox Biology Doxorubicin Endurance exercise Diaphragm Mechanical ventilation Muscle atrophy Heart |
| title | Mechanisms of exercise-induced preconditioning in skeletal muscles |
| title_full | Mechanisms of exercise-induced preconditioning in skeletal muscles |
| title_fullStr | Mechanisms of exercise-induced preconditioning in skeletal muscles |
| title_full_unstemmed | Mechanisms of exercise-induced preconditioning in skeletal muscles |
| title_short | Mechanisms of exercise-induced preconditioning in skeletal muscles |
| title_sort | mechanisms of exercise induced preconditioning in skeletal muscles |
| topic | Doxorubicin Endurance exercise Diaphragm Mechanical ventilation Muscle atrophy Heart |
| url | http://www.sciencedirect.com/science/article/pii/S2213231720300707 |
| work_keys_str_mv | AT scottkpowers mechanismsofexerciseinducedpreconditioninginskeletalmuscles AT matthewbomkamp mechanismsofexerciseinducedpreconditioninginskeletalmuscles AT mustafaozdemir mechanismsofexerciseinducedpreconditioninginskeletalmuscles AT haydenhyatt mechanismsofexerciseinducedpreconditioninginskeletalmuscles |