Reduced Size of Telangiectatic Capillaries After Intravitreal Injection of Anti-Vascular Endothelial Growth Factor Agents in Diabetic Macular Edema
Junichi Itou,1,* Kei Furushima,1,* Masatoshi Haruta,1 Nobuhiro Kato,1 Rikki Arai,1 Kenichiro Mori,2 Keijiro Ishikawa,2 Shigeo Yoshida1 1Department of Ophthalmology, Kurume University School of Medicine, Kurume, Japan; 2Department of Ophthalmology, Graduate School of Medical Sciences,...
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Dove Medical Press
2023-01-01
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| Series: | Clinical Ophthalmology |
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| Online Access: | https://www.dovepress.com/reduced-size-of-telangiectatic-capillaries-after-intravitreal-injectio-peer-reviewed-fulltext-article-OPTH |
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| author | Itou J Furushima K Haruta M Kato N Arai R Mori K Ishikawa K Yoshida S |
| author_facet | Itou J Furushima K Haruta M Kato N Arai R Mori K Ishikawa K Yoshida S |
| author_sort | Itou J |
| collection | DOAJ |
| description | Junichi Itou,1,* Kei Furushima,1,* Masatoshi Haruta,1 Nobuhiro Kato,1 Rikki Arai,1 Kenichiro Mori,2 Keijiro Ishikawa,2 Shigeo Yoshida1 1Department of Ophthalmology, Kurume University School of Medicine, Kurume, Japan; 2Department of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan*These authors contributed equally to this workCorrespondence: Shigeo Yoshida, Department of Ophthalmology, Kurume University School of Medicine, 67 Asahi-machi, Kurume, Fukuoka, 830-0011, Japan, Tel +81-942-317574, Fax +81-942-370324, Email yoshi@med.kurume-u.ac.jpPurpose: Intravitreal injection of anti-vascular endothelial growth factor (anti-VEGF) agents reduces microaneurysms in patients with diabetic macular edema (DME). However, residual anti-VEGF-resistant telangiectatic capillaries (TelCaps) have been reported. In this study, we investigated changes in the size of TelCaps after intravitreal injection of anti-VEGF agents in DME.Patients and Methods: Indocyanine green angiography (IA) and optical coherence tomography were performed before and 3 months after the intravitreal injection of anti-VEGF agents (pro re nata regimen after three monthly loading doses) in 12 eyes of 12 patients (7 males and 5 females, mean age 65.2 ± 8.8 years) with DME. The number and size of TelCaps within a 6-mm diameter macular region of the edema were measured using optical coherence tomography B-scan images overlaid on IA images.Results: There were significant reductions in the number and size of TelCaps between the baseline and 3 months after anti-VEGF agent administration (P < 0.05 and P < 0.0001, respectively). The maximum corrected visual acuity (logMAR visual acuity) and the central macular thickness after anti-VEGF therapy were significantly improved (P < 0.01 and P < 0.02, respectively). The TelCaps remaining after loading three consecutive anti-VEGF agents had a significantly larger mean size at baseline than the TelCaps that resolved after the treatment (P < 0.03).Conclusion: Our study demonstrated that intravitreal injection of anti-VEGF agents could reduce TelCap size in patients with DME. We propose that larger-sized TelCaps detected by IA might be useful predictors of refractory DME, which could thus be principal targets of laser photocoagulation.Keywords: anti-VEGF therapy, diabetic retinopathy, TelCap, indocyanine green angiography, microaneurysm, optical coherence tomography |
| first_indexed | 2024-04-10T21:25:49Z |
| format | Article |
| id | doaj.art-2f352741c51f4cab80ef00a4f6aebc5a |
| institution | Directory Open Access Journal |
| issn | 1177-5483 |
| language | English |
| last_indexed | 2024-04-10T21:25:49Z |
| publishDate | 2023-01-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Clinical Ophthalmology |
| spelling | doaj.art-2f352741c51f4cab80ef00a4f6aebc5a2023-01-19T17:31:53ZengDove Medical PressClinical Ophthalmology1177-54832023-01-01Volume 1723924581070Reduced Size of Telangiectatic Capillaries After Intravitreal Injection of Anti-Vascular Endothelial Growth Factor Agents in Diabetic Macular EdemaItou JFurushima KHaruta MKato NArai RMori KIshikawa KYoshida SJunichi Itou,1,* Kei Furushima,1,* Masatoshi Haruta,1 Nobuhiro Kato,1 Rikki Arai,1 Kenichiro Mori,2 Keijiro Ishikawa,2 Shigeo Yoshida1 1Department of Ophthalmology, Kurume University School of Medicine, Kurume, Japan; 2Department of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan*These authors contributed equally to this workCorrespondence: Shigeo Yoshida, Department of Ophthalmology, Kurume University School of Medicine, 67 Asahi-machi, Kurume, Fukuoka, 830-0011, Japan, Tel +81-942-317574, Fax +81-942-370324, Email yoshi@med.kurume-u.ac.jpPurpose: Intravitreal injection of anti-vascular endothelial growth factor (anti-VEGF) agents reduces microaneurysms in patients with diabetic macular edema (DME). However, residual anti-VEGF-resistant telangiectatic capillaries (TelCaps) have been reported. In this study, we investigated changes in the size of TelCaps after intravitreal injection of anti-VEGF agents in DME.Patients and Methods: Indocyanine green angiography (IA) and optical coherence tomography were performed before and 3 months after the intravitreal injection of anti-VEGF agents (pro re nata regimen after three monthly loading doses) in 12 eyes of 12 patients (7 males and 5 females, mean age 65.2 ± 8.8 years) with DME. The number and size of TelCaps within a 6-mm diameter macular region of the edema were measured using optical coherence tomography B-scan images overlaid on IA images.Results: There were significant reductions in the number and size of TelCaps between the baseline and 3 months after anti-VEGF agent administration (P < 0.05 and P < 0.0001, respectively). The maximum corrected visual acuity (logMAR visual acuity) and the central macular thickness after anti-VEGF therapy were significantly improved (P < 0.01 and P < 0.02, respectively). The TelCaps remaining after loading three consecutive anti-VEGF agents had a significantly larger mean size at baseline than the TelCaps that resolved after the treatment (P < 0.03).Conclusion: Our study demonstrated that intravitreal injection of anti-VEGF agents could reduce TelCap size in patients with DME. We propose that larger-sized TelCaps detected by IA might be useful predictors of refractory DME, which could thus be principal targets of laser photocoagulation.Keywords: anti-VEGF therapy, diabetic retinopathy, TelCap, indocyanine green angiography, microaneurysm, optical coherence tomographyhttps://www.dovepress.com/reduced-size-of-telangiectatic-capillaries-after-intravitreal-injectio-peer-reviewed-fulltext-article-OPTHanti-vegf therapydiabetic retinopathytelcapindocyanine green angiographymicroaneurysmoptical coherence tomography |
| spellingShingle | Itou J Furushima K Haruta M Kato N Arai R Mori K Ishikawa K Yoshida S Reduced Size of Telangiectatic Capillaries After Intravitreal Injection of Anti-Vascular Endothelial Growth Factor Agents in Diabetic Macular Edema Clinical Ophthalmology anti-vegf therapy diabetic retinopathy telcap indocyanine green angiography microaneurysm optical coherence tomography |
| title | Reduced Size of Telangiectatic Capillaries After Intravitreal Injection of Anti-Vascular Endothelial Growth Factor Agents in Diabetic Macular Edema |
| title_full | Reduced Size of Telangiectatic Capillaries After Intravitreal Injection of Anti-Vascular Endothelial Growth Factor Agents in Diabetic Macular Edema |
| title_fullStr | Reduced Size of Telangiectatic Capillaries After Intravitreal Injection of Anti-Vascular Endothelial Growth Factor Agents in Diabetic Macular Edema |
| title_full_unstemmed | Reduced Size of Telangiectatic Capillaries After Intravitreal Injection of Anti-Vascular Endothelial Growth Factor Agents in Diabetic Macular Edema |
| title_short | Reduced Size of Telangiectatic Capillaries After Intravitreal Injection of Anti-Vascular Endothelial Growth Factor Agents in Diabetic Macular Edema |
| title_sort | reduced size of telangiectatic capillaries after intravitreal injection of anti vascular endothelial growth factor agents in diabetic macular edema |
| topic | anti-vegf therapy diabetic retinopathy telcap indocyanine green angiography microaneurysm optical coherence tomography |
| url | https://www.dovepress.com/reduced-size-of-telangiectatic-capillaries-after-intravitreal-injectio-peer-reviewed-fulltext-article-OPTH |
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