Case report: Successful treatment of non-bullous lichen planus pemphigoides with dupilumab
Lichen planus pemphigoides (LPP) is a rare autoimmune bullous disease, characterized by the coexistence of lichen planus and subepidermal bullae. However, the minority of LPP patients present with papules rather than vesicles or blisters, which is defined as non-bullous LPP. The diagnosis of LPP rel...
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| Format: | Article |
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Frontiers Media S.A.
2022-12-01
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| Series: | Frontiers in Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2022.1023458/full |
| _version_ | 1811198659855908864 |
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| author | Si-Zhe Li Ying-Han Xie Si-Hang Wang Rou-Yu Fang Hong-Zhong Jin Ya-Gang Zuo |
| author_facet | Si-Zhe Li Ying-Han Xie Si-Hang Wang Rou-Yu Fang Hong-Zhong Jin Ya-Gang Zuo |
| author_sort | Si-Zhe Li |
| collection | DOAJ |
| description | Lichen planus pemphigoides (LPP) is a rare autoimmune bullous disease, characterized by the coexistence of lichen planus and subepidermal bullae. However, the minority of LPP patients present with papules rather than vesicles or blisters, which is defined as non-bullous LPP. The diagnosis of LPP relies on manifestations, histopathology, serological assay, and direct immunofluorescence of linear disposition of IgG and/or C3 at the basement membrane zone. Up to now, no standard therapeutic strategies have been proposed for the treatment of LPP. Herein, we describe an uncommon non-bullous LPP patient with widespread papules and erythema, probably induced by vaccination. During hospitalization, he had a poor response to the conventional treatment of topical and systemic corticosteroids, and his condition was finally alleviated by the addition of dupilumab. For LPP patients with a traditional medication failure, or who were not suitable for a higher dose of corticosteroids, a combination with dupilumab could be an alternative option. |
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| institution | Directory Open Access Journal |
| issn | 2296-858X |
| language | English |
| last_indexed | 2024-04-12T01:35:00Z |
| publishDate | 2022-12-01 |
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| series | Frontiers in Medicine |
| spelling | doaj.art-2f3626e2071445d1b8ff0f11bfa617b72022-12-22T03:53:21ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2022-12-01910.3389/fmed.2022.10234581023458Case report: Successful treatment of non-bullous lichen planus pemphigoides with dupilumabSi-Zhe LiYing-Han XieSi-Hang WangRou-Yu FangHong-Zhong JinYa-Gang ZuoLichen planus pemphigoides (LPP) is a rare autoimmune bullous disease, characterized by the coexistence of lichen planus and subepidermal bullae. However, the minority of LPP patients present with papules rather than vesicles or blisters, which is defined as non-bullous LPP. The diagnosis of LPP relies on manifestations, histopathology, serological assay, and direct immunofluorescence of linear disposition of IgG and/or C3 at the basement membrane zone. Up to now, no standard therapeutic strategies have been proposed for the treatment of LPP. Herein, we describe an uncommon non-bullous LPP patient with widespread papules and erythema, probably induced by vaccination. During hospitalization, he had a poor response to the conventional treatment of topical and systemic corticosteroids, and his condition was finally alleviated by the addition of dupilumab. For LPP patients with a traditional medication failure, or who were not suitable for a higher dose of corticosteroids, a combination with dupilumab could be an alternative option.https://www.frontiersin.org/articles/10.3389/fmed.2022.1023458/fulllichen planus pemphigoidsnon-bullousdupilumabvaccinelichen planuscorticosteroid |
| spellingShingle | Si-Zhe Li Ying-Han Xie Si-Hang Wang Rou-Yu Fang Hong-Zhong Jin Ya-Gang Zuo Case report: Successful treatment of non-bullous lichen planus pemphigoides with dupilumab Frontiers in Medicine lichen planus pemphigoids non-bullous dupilumab vaccine lichen planus corticosteroid |
| title | Case report: Successful treatment of non-bullous lichen planus pemphigoides with dupilumab |
| title_full | Case report: Successful treatment of non-bullous lichen planus pemphigoides with dupilumab |
| title_fullStr | Case report: Successful treatment of non-bullous lichen planus pemphigoides with dupilumab |
| title_full_unstemmed | Case report: Successful treatment of non-bullous lichen planus pemphigoides with dupilumab |
| title_short | Case report: Successful treatment of non-bullous lichen planus pemphigoides with dupilumab |
| title_sort | case report successful treatment of non bullous lichen planus pemphigoides with dupilumab |
| topic | lichen planus pemphigoids non-bullous dupilumab vaccine lichen planus corticosteroid |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2022.1023458/full |
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