Functionalized Hybrid Iron Oxide–Gold Nanoparticles Targeting Membrane Hsp70 Radiosensitize Triple-Negative Breast Cancer Cells by ROS-Mediated Apoptosis

Functionalized Hybrid Iron Oxide–Gold Nanoparticles Targeting Membrane Hsp70 Radiosensitize Triple-Negative Breast Cancer Cells by ROS-Mediated Apoptosis

Triple-negative breast cancer (TNBC) a highly aggressive tumor entity with an unfavorable prognosis, is treated by multimodal therapies, including ionizing radiation (IR). Radiation-resistant tumor cells, as well as induced normal tissue toxicity, contribute to the poor clinical outcome of the disea...

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Bibliographic Details
Main Authors: Zhiyuan Wu, Stefan Stangl, Alicia Hernandez-Schnelzer, Fei Wang, Morteza Hasanzadeh Kafshgari, Ali Bashiri Dezfouli, Gabriele Multhoff
Format: Article
Language:English
Published: MDPI AG 2023-02-01
Series:Cancers
Subjects:
TNBC
Hsp70
TPP-PEG4-FeAuNPs
ROS
Online Access:https://www.mdpi.com/2072-6694/15/4/1167

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