Recent Advances in Elastin-Based Biomaterial
Elastin is one of the main components of the extracellular matrix; it provides resistance and elasticity to a variety of tissues and organs of the human body, besides participating in cellular signaling. On the other hand, elastin-derived peptides are synthetic biopolymers with a similar conformatio...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2020-08-01
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| Series: | Journal of Pharmacy & Pharmaceutical Sciences |
| Online Access: | https://journals.library.ualberta.ca/jpps/index.php/JPPS/article/view/31254 |
| _version_ | 1797722187713478656 |
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| author | María Luisa Del Prado Audelo Néstor Mendoza-Muñoz Lidia Escutia-Guadarrama David Giraldo-Gomez Maykel González-Torres Benjamín Florán Hernán Cortés Gerardo Leyva-Gomez |
| author_facet | María Luisa Del Prado Audelo Néstor Mendoza-Muñoz Lidia Escutia-Guadarrama David Giraldo-Gomez Maykel González-Torres Benjamín Florán Hernán Cortés Gerardo Leyva-Gomez |
| author_sort | María Luisa Del Prado Audelo |
| collection | DOAJ |
| description | Elastin is one of the main components of the extracellular matrix; it provides resistance and elasticity to a variety of tissues and organs of the human body, besides participating in cellular signaling. On the other hand, elastin-derived peptides are synthetic biopolymers with a similar conformation and structure to elastin, but these possess the advantage of solubility in aqueous mediums. Due to their biological activities and physicochemical properties, elastin and related peptides may be applied as biomaterials to develop diverse biomedical devices, including scaffolds, hydrogels, and drug delivery systems for tissue engineering. Likewise, the combination of elastin with natural or synthetic polymers has demonstrated to improve the mechanical properties of biomedical products and drug delivery systems. Here we comprehensively describe the physicochemical properties and physiological functions of elastin. Moreover, we offer an overview of the use of elastin and its derivative polymers as biomaterials to develop scaffolds and hydrogels for tissue engineering. Finally, we discuss some perspectives on the employment of these biopolymers to fabricate new biomedical products. |
| first_indexed | 2024-03-12T09:43:53Z |
| format | Article |
| id | doaj.art-2f36346877234440bf78ec6f8cab7e5e |
| institution | Directory Open Access Journal |
| issn | 1482-1826 |
| language | English |
| last_indexed | 2024-03-12T09:43:53Z |
| publishDate | 2020-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Journal of Pharmacy & Pharmaceutical Sciences |
| spelling | doaj.art-2f36346877234440bf78ec6f8cab7e5e2023-09-02T13:00:35ZengFrontiers Media S.A.Journal of Pharmacy & Pharmaceutical Sciences1482-18262020-08-0123110.18433/jpps31254Recent Advances in Elastin-Based BiomaterialMaría Luisa Del Prado Audelo0Néstor Mendoza-Muñoz1Lidia Escutia-Guadarrama2David Giraldo-Gomez3Maykel González-Torres4Benjamín Florán5Hernán Cortés6Gerardo Leyva-Gomez7Departamento de Farmacia, Facultad de Química, Universidad Nacional Autónoma de México, Ciudad de México, 04510, Mexico. Escuela de Ingeniería y Ciencias, Departamento de Bioingeniería, Tecnológico de Monterrey, Campus Ciudad de México, Ciudad de México, 14380, MexicoFacultad de Ciencias Químicas, Universidad de Colima, Colima, 28400, Mexico.Departamento de Física, Facultad de Ciencias, Universidad Nacional Autónoma de México, Ciudad de México, 04510, Mexico.Departamento de Biología Celular y Tisular, Facultad de Medicina, Universidad Nacional Autónoma de México, Ciudad de México, 04510, Mexico. Unidad de Microscopía, Facultad de Medicina, Universidad Nacional Autónoma de México, Ciudad de México, 04510, Mexico.CONACyT-Laboratorio de Biotecnología, Instituto Nacional de Rehabilitación Luis Guillermo Ibarra Ibarra, Ciudad de México, 14389, Mexico.Departamento de Fisiología, Biofísica & Neurociencias, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional, Ciudad de México, 07360, Mexico.Laboratorio de Medicina Genómica, Departamento de Genómica, Instituto Nacional de Rehabilitación Luis Guillermo Ibarra Ibarra, Ciudad de México, 14389, Mexico.Departamento de Farmacia, Facultad de Química, Universidad Nacional Autónoma de México, Ciudad de México, 04510, Mexico.Elastin is one of the main components of the extracellular matrix; it provides resistance and elasticity to a variety of tissues and organs of the human body, besides participating in cellular signaling. On the other hand, elastin-derived peptides are synthetic biopolymers with a similar conformation and structure to elastin, but these possess the advantage of solubility in aqueous mediums. Due to their biological activities and physicochemical properties, elastin and related peptides may be applied as biomaterials to develop diverse biomedical devices, including scaffolds, hydrogels, and drug delivery systems for tissue engineering. Likewise, the combination of elastin with natural or synthetic polymers has demonstrated to improve the mechanical properties of biomedical products and drug delivery systems. Here we comprehensively describe the physicochemical properties and physiological functions of elastin. Moreover, we offer an overview of the use of elastin and its derivative polymers as biomaterials to develop scaffolds and hydrogels for tissue engineering. Finally, we discuss some perspectives on the employment of these biopolymers to fabricate new biomedical products.https://journals.library.ualberta.ca/jpps/index.php/JPPS/article/view/31254 |
| spellingShingle | María Luisa Del Prado Audelo Néstor Mendoza-Muñoz Lidia Escutia-Guadarrama David Giraldo-Gomez Maykel González-Torres Benjamín Florán Hernán Cortés Gerardo Leyva-Gomez Recent Advances in Elastin-Based Biomaterial Journal of Pharmacy & Pharmaceutical Sciences |
| title | Recent Advances in Elastin-Based Biomaterial |
| title_full | Recent Advances in Elastin-Based Biomaterial |
| title_fullStr | Recent Advances in Elastin-Based Biomaterial |
| title_full_unstemmed | Recent Advances in Elastin-Based Biomaterial |
| title_short | Recent Advances in Elastin-Based Biomaterial |
| title_sort | recent advances in elastin based biomaterial |
| url | https://journals.library.ualberta.ca/jpps/index.php/JPPS/article/view/31254 |
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