The role of interleukin-1 in perinatal inflammation and its impact on transitional circulation
Preterm birth is defined as delivery at <37 weeks of gestational age (GA) and exposes 15 million infants worldwide to serious early life diseases. Lowering the age of viability to 22 weeks GA entailed provision of intensive care to a greater number of extremely premature infants. Moreover, im...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-03-01
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| Series: | Frontiers in Pediatrics |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fped.2023.1130013/full |
| _version_ | 1797884395591303168 |
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| author | Josephine C. Owen Josephine C. Owen Steven P. Garrick Steven P. Garrick Briana M. Peterson Briana M. Peterson Philip J. Berger Philip J. Berger Marcel F. Nold Marcel F. Nold Marcel F. Nold Arvind Sehgal Arvind Sehgal Claudia A. Nold-Petry Claudia A. Nold-Petry |
| author_facet | Josephine C. Owen Josephine C. Owen Steven P. Garrick Steven P. Garrick Briana M. Peterson Briana M. Peterson Philip J. Berger Philip J. Berger Marcel F. Nold Marcel F. Nold Marcel F. Nold Arvind Sehgal Arvind Sehgal Claudia A. Nold-Petry Claudia A. Nold-Petry |
| author_sort | Josephine C. Owen |
| collection | DOAJ |
| description | Preterm birth is defined as delivery at <37 weeks of gestational age (GA) and exposes 15 million infants worldwide to serious early life diseases. Lowering the age of viability to 22 weeks GA entailed provision of intensive care to a greater number of extremely premature infants. Moreover, improved survival, especially at extremes of prematurity, comes with a rising incidence of early life diseases with short- and long-term sequelae. The transition from fetal to neonatal circulation is a substantial and complex physiologic adaptation, which normally happens rapidly and in an orderly sequence. Maternal chorioamnionitis or fetal growth restriction (FGR) are two common causes of preterm birth that are associated with impaired circulatory transition. Among many cytokines contributing to the pathogenesis of chorioamnionitis-related perinatal inflammatory diseases, the potent pro-inflammatory interleukin (IL)-1 has been shown to play a central role. The effects of utero-placental insufficiency-related FGR and in-utero hypoxia may also be mediated, in part, via the inflammatory cascade. In preclinical studies, blocking such inflammation, early and effectively, holds great promise for improving the transition of circulation. In this mini-review, we outline the mechanistic pathways leading to abnormalities in transitional circulation in chorioamnionitis and FGR. In addition, we explore the therapeutic potential of targeting IL-1 and its influence on perinatal transition in the context of chorioamnionitis and FGR. |
| first_indexed | 2024-04-10T04:06:59Z |
| format | Article |
| id | doaj.art-2f38a545ab6f4be389709b70050b4fb2 |
| institution | Directory Open Access Journal |
| issn | 2296-2360 |
| language | English |
| last_indexed | 2024-04-10T04:06:59Z |
| publishDate | 2023-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pediatrics |
| spelling | doaj.art-2f38a545ab6f4be389709b70050b4fb22023-03-13T04:40:37ZengFrontiers Media S.A.Frontiers in Pediatrics2296-23602023-03-011110.3389/fped.2023.11300131130013The role of interleukin-1 in perinatal inflammation and its impact on transitional circulationJosephine C. Owen0Josephine C. Owen1Steven P. Garrick2Steven P. Garrick3Briana M. Peterson4Briana M. Peterson5Philip J. Berger6Philip J. Berger7Marcel F. Nold8Marcel F. Nold9Marcel F. Nold10Arvind Sehgal11Arvind Sehgal12Claudia A. Nold-Petry13Claudia A. Nold-Petry14Ritchie Centre, Hudson Institute of Medical Research, Melbourne, VIC, AustraliaDepartment of Paediatrics, Monash University, Melbourne, VIC, AustraliaRitchie Centre, Hudson Institute of Medical Research, Melbourne, VIC, AustraliaDepartment of Paediatrics, Monash University, Melbourne, VIC, AustraliaRitchie Centre, Hudson Institute of Medical Research, Melbourne, VIC, AustraliaDepartment of Paediatrics, Monash University, Melbourne, VIC, AustraliaRitchie Centre, Hudson Institute of Medical Research, Melbourne, VIC, AustraliaDepartment of Paediatrics, Monash University, Melbourne, VIC, AustraliaRitchie Centre, Hudson Institute of Medical Research, Melbourne, VIC, AustraliaDepartment of Paediatrics, Monash University, Melbourne, VIC, AustraliaMonash Newborn, Monash Children’s Hospital, Melbourne, VIC, AustraliaDepartment of Paediatrics, Monash University, Melbourne, VIC, AustraliaMonash Newborn, Monash Children’s Hospital, Melbourne, VIC, AustraliaRitchie Centre, Hudson Institute of Medical Research, Melbourne, VIC, AustraliaDepartment of Paediatrics, Monash University, Melbourne, VIC, AustraliaPreterm birth is defined as delivery at <37 weeks of gestational age (GA) and exposes 15 million infants worldwide to serious early life diseases. Lowering the age of viability to 22 weeks GA entailed provision of intensive care to a greater number of extremely premature infants. Moreover, improved survival, especially at extremes of prematurity, comes with a rising incidence of early life diseases with short- and long-term sequelae. The transition from fetal to neonatal circulation is a substantial and complex physiologic adaptation, which normally happens rapidly and in an orderly sequence. Maternal chorioamnionitis or fetal growth restriction (FGR) are two common causes of preterm birth that are associated with impaired circulatory transition. Among many cytokines contributing to the pathogenesis of chorioamnionitis-related perinatal inflammatory diseases, the potent pro-inflammatory interleukin (IL)-1 has been shown to play a central role. The effects of utero-placental insufficiency-related FGR and in-utero hypoxia may also be mediated, in part, via the inflammatory cascade. In preclinical studies, blocking such inflammation, early and effectively, holds great promise for improving the transition of circulation. In this mini-review, we outline the mechanistic pathways leading to abnormalities in transitional circulation in chorioamnionitis and FGR. In addition, we explore the therapeutic potential of targeting IL-1 and its influence on perinatal transition in the context of chorioamnionitis and FGR.https://www.frontiersin.org/articles/10.3389/fped.2023.1130013/fullperinatal inflammationtransitional circulationinterleukin-1chorioamnionitisfetal growth restriction |
| spellingShingle | Josephine C. Owen Josephine C. Owen Steven P. Garrick Steven P. Garrick Briana M. Peterson Briana M. Peterson Philip J. Berger Philip J. Berger Marcel F. Nold Marcel F. Nold Marcel F. Nold Arvind Sehgal Arvind Sehgal Claudia A. Nold-Petry Claudia A. Nold-Petry The role of interleukin-1 in perinatal inflammation and its impact on transitional circulation Frontiers in Pediatrics perinatal inflammation transitional circulation interleukin-1 chorioamnionitis fetal growth restriction |
| title | The role of interleukin-1 in perinatal inflammation and its impact on transitional circulation |
| title_full | The role of interleukin-1 in perinatal inflammation and its impact on transitional circulation |
| title_fullStr | The role of interleukin-1 in perinatal inflammation and its impact on transitional circulation |
| title_full_unstemmed | The role of interleukin-1 in perinatal inflammation and its impact on transitional circulation |
| title_short | The role of interleukin-1 in perinatal inflammation and its impact on transitional circulation |
| title_sort | role of interleukin 1 in perinatal inflammation and its impact on transitional circulation |
| topic | perinatal inflammation transitional circulation interleukin-1 chorioamnionitis fetal growth restriction |
| url | https://www.frontiersin.org/articles/10.3389/fped.2023.1130013/full |
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