Signatures of T and B Cell Development, Functional Responses and PD-1 Upregulation After HCMV Latent Infections and Reactivations in Nod.Rag.Gamma Mice Humanized With Cord Blood CD34+ Cells

Signatures of T and B Cell Development, Functional Responses and PD-1 Upregulation After HCMV Latent Infections and Reactivations in Nod.Rag.Gamma Mice Humanized With Cord Blood CD34+ Cells

Human cytomegalovirus (HCMV) latency is typically harmless but reactivation can be largely detrimental to immune compromised hosts. We modeled latency and reactivation using a traceable HCMV laboratory strain expressing the Gaussia luciferase reporter gene (HCMV/GLuc) in order to interrogate the vir...

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Bibliographic Details
Main Authors: Sebastian J. Theobald, Sahamoddin Khailaie, Michael Meyer-Hermann, Valery Volk, Henning Olbrich, Simon Danisch, Laura Gerasch, Andreas Schneider, Christian Sinzger, Dirk Schaudien, Stefan Lienenklaus, Peggy Riese, Carlos A. Guzman, Constanca Figueiredo, Constantin von Kaisenberg, Loukia M. Spineli, Stephanie Glaesener, Almut Meyer-Bahlburg, Arnold Ganser, Michael Schmitt, Michael Mach, Martin Messerle, Renata Stripecke
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-11-01
Series:Frontiers in Immunology
Subjects:
HCMV
reactivation
humanized mice
T cell maturation
B cell class switch
optical imaging analyses
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.02734/full

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