Lycium barbarum Ameliorates Neural Damage Induced by Experimental Ischemic Stroke and Radiation Exposure
Ischemic stroke and cranial radiotherapy may induce brain inflammatory response, oxidative stress, apoptosis and neuronal loss, and impairment of neurogenesis. Lycium barbarum has anti-oxidation, anti-inflammatory, anti-tumor and anti-aging properties, may produce both neuroprotective and radioprote...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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IMR Press
2023-02-01
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| Series: | Frontiers in Bioscience-Landmark |
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| Online Access: | https://www.imrpress.com/journal/FBL/28/2/10.31083/j.fbl2802038 |
| _version_ | 1811160676454891520 |
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| author | Yan Huang Xing Zhang Ling Chen Bo Xu Ren Feng Ru Tang |
| author_facet | Yan Huang Xing Zhang Ling Chen Bo Xu Ren Feng Ru Tang |
| author_sort | Yan Huang |
| collection | DOAJ |
| description | Ischemic stroke and cranial radiotherapy may induce brain inflammatory response, oxidative stress, apoptosis and neuronal loss, and impairment of neurogenesis. Lycium barbarum has anti-oxidation, anti-inflammatory, anti-tumor and anti-aging properties, may produce both neuroprotective and radioprotective effects. In this narrative review paper, we described the neuroprotective effect of Lycium barbarum in different animal models of experimental ischemic stroke and limited studies in irradiated animal models. Relevant molecular mechanisms are also summarized. It has been shown that in experimental ischemic stroke models, Lycium barbarum produces neuroprotective effects by modulating neuroinflammatory factors such as cytokines and chemokines, reactive oxygen species, and neurotransmitter and receptor systems. In irradiation animal models, Lycium barbarum prevents radiation-induced loss of hippocampal interneurons. Given its minimal side-effects, these preclinical studies suggest that Lycium barbarum may be a promising radio-neuro-protective drug that can be used as an adjunct treatment to radiotherapy for brain tumor and in the treatment of ischemic stroke. At molecular levels, Lycium barbarum may regulate PI3K/Akt/GSK-3β, PI3K/Akt/mTOR, PKCε/Nrf2/HO-1, keap1-Nrf2/HO-1, and NR2A and NR2B receptor- related signal transduction pathways to produce neuroprotective effects. |
| first_indexed | 2024-04-10T06:01:24Z |
| format | Article |
| id | doaj.art-2f39a7a0dc3343b18a5cf8e08f71c2f7 |
| institution | Directory Open Access Journal |
| issn | 2768-6701 |
| language | English |
| last_indexed | 2024-04-10T06:01:24Z |
| publishDate | 2023-02-01 |
| publisher | IMR Press |
| record_format | Article |
| series | Frontiers in Bioscience-Landmark |
| spelling | doaj.art-2f39a7a0dc3343b18a5cf8e08f71c2f72023-03-03T08:24:30ZengIMR PressFrontiers in Bioscience-Landmark2768-67012023-02-012823810.31083/j.fbl2802038S2768-6701(23)00792-XLycium barbarum Ameliorates Neural Damage Induced by Experimental Ischemic Stroke and Radiation ExposureYan Huang0Xing Zhang1Ling Chen2Bo Xu Ren3Feng Ru Tang4Department of Medical Imaging, Medical School of Yangtze University, 434023 Jingzhou, Hubei, ChinaDepartment of Medical Imaging, Medical School of Yangtze University, 434023 Jingzhou, Hubei, ChinaDepartment of General Practice, Wuhan Fourth Hospital, 430033 Wuhan, Hubei, ChinaDepartment of Medical Imaging, Medical School of Yangtze University, 434023 Jingzhou, Hubei, ChinaRadiation Physiology Lab, Singapore Nuclear Research and Safety Initiative, National University of Singapore, 138602 Singapore, SingaporeIschemic stroke and cranial radiotherapy may induce brain inflammatory response, oxidative stress, apoptosis and neuronal loss, and impairment of neurogenesis. Lycium barbarum has anti-oxidation, anti-inflammatory, anti-tumor and anti-aging properties, may produce both neuroprotective and radioprotective effects. In this narrative review paper, we described the neuroprotective effect of Lycium barbarum in different animal models of experimental ischemic stroke and limited studies in irradiated animal models. Relevant molecular mechanisms are also summarized. It has been shown that in experimental ischemic stroke models, Lycium barbarum produces neuroprotective effects by modulating neuroinflammatory factors such as cytokines and chemokines, reactive oxygen species, and neurotransmitter and receptor systems. In irradiation animal models, Lycium barbarum prevents radiation-induced loss of hippocampal interneurons. Given its minimal side-effects, these preclinical studies suggest that Lycium barbarum may be a promising radio-neuro-protective drug that can be used as an adjunct treatment to radiotherapy for brain tumor and in the treatment of ischemic stroke. At molecular levels, Lycium barbarum may regulate PI3K/Akt/GSK-3β, PI3K/Akt/mTOR, PKCε/Nrf2/HO-1, keap1-Nrf2/HO-1, and NR2A and NR2B receptor- related signal transduction pathways to produce neuroprotective effects.https://www.imrpress.com/journal/FBL/28/2/10.31083/j.fbl2802038ischemic strokeradiationradiotherapyapoptosisinflammationoxidative stresslycium barbarumneuroprotectivemolecular mechanismslycium barbarum polysaccharides |
| spellingShingle | Yan Huang Xing Zhang Ling Chen Bo Xu Ren Feng Ru Tang Lycium barbarum Ameliorates Neural Damage Induced by Experimental Ischemic Stroke and Radiation Exposure Frontiers in Bioscience-Landmark ischemic stroke radiation radiotherapy apoptosis inflammation oxidative stress lycium barbarum neuroprotective molecular mechanisms lycium barbarum polysaccharides |
| title | Lycium barbarum Ameliorates Neural Damage Induced by Experimental Ischemic Stroke and Radiation Exposure |
| title_full | Lycium barbarum Ameliorates Neural Damage Induced by Experimental Ischemic Stroke and Radiation Exposure |
| title_fullStr | Lycium barbarum Ameliorates Neural Damage Induced by Experimental Ischemic Stroke and Radiation Exposure |
| title_full_unstemmed | Lycium barbarum Ameliorates Neural Damage Induced by Experimental Ischemic Stroke and Radiation Exposure |
| title_short | Lycium barbarum Ameliorates Neural Damage Induced by Experimental Ischemic Stroke and Radiation Exposure |
| title_sort | lycium barbarum ameliorates neural damage induced by experimental ischemic stroke and radiation exposure |
| topic | ischemic stroke radiation radiotherapy apoptosis inflammation oxidative stress lycium barbarum neuroprotective molecular mechanisms lycium barbarum polysaccharides |
| url | https://www.imrpress.com/journal/FBL/28/2/10.31083/j.fbl2802038 |
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