Molecular Design of NIR-II Polymethine Fluorophores for Bioimaging and Biosensing
Organic polymethine fluorophores with emission in the NIR-II window (1000–1700 nm) are receiving enormous attention in biomolecular medicine and bioimaging, attributed to the high absorption coefficients, bright NIR-II emission, excellent biocompatibility, and molecule adjustability. Recently, resea...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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American Chemical Society
2023-05-01
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| Series: | Chemical & Biomedical Imaging |
| Online Access: | https://doi.org/10.1021/cbmi.3c00040 |
| _version_ | 1797739806850023424 |
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| author | Yi-Feng Ou Tian-Bing Ren Lin Yuan Xiao-Bing Zhang |
| author_facet | Yi-Feng Ou Tian-Bing Ren Lin Yuan Xiao-Bing Zhang |
| author_sort | Yi-Feng Ou |
| collection | DOAJ |
| description | Organic polymethine fluorophores with emission in the NIR-II window (1000–1700 nm) are receiving enormous attention in biomolecular medicine and bioimaging, attributed to the high absorption coefficients, bright NIR-II emission, excellent biocompatibility, and molecule adjustability. Recently, researchers have devoted significant effort to designing and improving NIR-II polymethine fluorophores and making notable progress in the NIR-II fluorescence imaging performance. This review summarizes recent developments in the molecular engineering design mentality of polymethine fluorophores and probes and highlights their extensive bioimaging and biosensing applications. Furthermore, we elucidate the potential challenges and perspectives of these NIR-II polymethine dyes in chemical and biomedicine imaging, which may stimulate the further development of high-performance NIR-II polymethine dye contrast agents for their future clinical applications. |
| first_indexed | 2024-03-12T14:03:28Z |
| format | Article |
| id | doaj.art-2f3a6da1473c486da0165d2fcab00315 |
| institution | Directory Open Access Journal |
| issn | 2832-3637 |
| language | English |
| last_indexed | 2024-03-12T14:03:28Z |
| publishDate | 2023-05-01 |
| publisher | American Chemical Society |
| record_format | Article |
| series | Chemical & Biomedical Imaging |
| spelling | doaj.art-2f3a6da1473c486da0165d2fcab003152023-08-21T17:58:59ZengAmerican Chemical SocietyChemical & Biomedical Imaging2832-36372023-05-011322023310.1021/cbmi.3c00040Molecular Design of NIR-II Polymethine Fluorophores for Bioimaging and BiosensingYi-Feng OuTian-Bing RenLin YuanXiao-Bing ZhangOrganic polymethine fluorophores with emission in the NIR-II window (1000–1700 nm) are receiving enormous attention in biomolecular medicine and bioimaging, attributed to the high absorption coefficients, bright NIR-II emission, excellent biocompatibility, and molecule adjustability. Recently, researchers have devoted significant effort to designing and improving NIR-II polymethine fluorophores and making notable progress in the NIR-II fluorescence imaging performance. This review summarizes recent developments in the molecular engineering design mentality of polymethine fluorophores and probes and highlights their extensive bioimaging and biosensing applications. Furthermore, we elucidate the potential challenges and perspectives of these NIR-II polymethine dyes in chemical and biomedicine imaging, which may stimulate the further development of high-performance NIR-II polymethine dye contrast agents for their future clinical applications.https://doi.org/10.1021/cbmi.3c00040 |
| spellingShingle | Yi-Feng Ou Tian-Bing Ren Lin Yuan Xiao-Bing Zhang Molecular Design of NIR-II Polymethine Fluorophores for Bioimaging and Biosensing Chemical & Biomedical Imaging |
| title | Molecular Design of NIR-II Polymethine Fluorophores for Bioimaging and Biosensing |
| title_full | Molecular Design of NIR-II Polymethine Fluorophores for Bioimaging and Biosensing |
| title_fullStr | Molecular Design of NIR-II Polymethine Fluorophores for Bioimaging and Biosensing |
| title_full_unstemmed | Molecular Design of NIR-II Polymethine Fluorophores for Bioimaging and Biosensing |
| title_short | Molecular Design of NIR-II Polymethine Fluorophores for Bioimaging and Biosensing |
| title_sort | molecular design of nir ii polymethine fluorophores for bioimaging and biosensing |
| url | https://doi.org/10.1021/cbmi.3c00040 |
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