Biopsy-proven recurrent, acute, familial hypersensitivity pneumonitis: A case report and literature review

Hypersensitivity pneumonitis (HP) is characterized by inflammation of the lung parenchyma that is induced by exposure to an inhaled organic antigen. We present a case of recurrent, acute HP caused by repeated transient exposure to a down sleeping bag in a patient with a family history of chronic bir...

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Bibliographic Details
Main Authors: Tiffany Winstone, Cameron J. Hague, Andrew Churg, Joanne L. Wright, Robert Schellenberg, Chris Ryerson
Format: Article
Language:English
Published: Elsevier 2018-01-01
Series:Respiratory Medicine Case Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2213007117303258
Description
Summary:Hypersensitivity pneumonitis (HP) is characterized by inflammation of the lung parenchyma that is induced by exposure to an inhaled organic antigen. We present a case of recurrent, acute HP caused by repeated transient exposure to a down sleeping bag in a patient with a family history of chronic bird-associated hypersensitivity pneumonitis. The patient's recurrent symptoms, changes in physiology, and radiographic findings coincided with repeated exposure to this source. It was later confirmed that the patient's sister had also developed chronic HP from recurrent exposure to household birds. This case highlights recent studies implicating gene-exposure interactions in the development of HP. Keywords: Hypersensitivity pneumonitis, Familial hypersensitivity pneumonitis, Organic antigen, Interstitial lung disease
ISSN:2213-0071