Hepatic and Renal Functions in HIV-Positive Children with Malaria in Western Kenya
Background: The burden of HIV and malaria co-infection lies disproportionately in the Sub-Saharan Africa region which bears most of the malaria endemic zones. While both malaria and HIV are known to dysregulate hepatic and renal functions, the combined effect of co-infection with malaria and HIV on...
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| Format: | Article |
| Language: | English |
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Medical and Dental Consultants Association of Nigeria, OOUTH Sagamu
2023-12-01
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| Series: | Annals of Health Research |
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| Online Access: | https://www.annalsofhealthresearch.com/index.php/ahr/article/view/505 |
| _version_ | 1797296125917528064 |
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| author | Mambo FA Shaviya N Were T |
| author_facet | Mambo FA Shaviya N Were T |
| author_sort | Mambo FA |
| collection | DOAJ |
| description | Background: The burden of HIV and malaria co-infection lies disproportionately in the Sub-Saharan Africa region which bears most of the malaria endemic zones. While both malaria and HIV are known to dysregulate hepatic and renal functions, the combined effect of co-infection with malaria and HIV on hepatic and renal function among children remains poorly characterized.
Objective: To assess liver and renal functions in HIV-malaria co-infected children in Western Kenya.
Methods: A cross-sectional study was conducted among children aged 6-59 months with HIV and malaria coinfection at Kakamega County Referral Hospital, Western Kenya. A total of 138 children were enrolled. Microscopy and clinical chemistry analysers were used to diagnose malaria, and assay hepatic and renal function parameters respectively.
Results: HIV positive-malaria positive cases had significantly higher serum creatinine and urea levels compared to the HIV positive-malaria negative controls. Likewise, serum levels of the alanine aminotransferase (ALT), aspartate aminotransferase (AST), gamma glutamyl transferase (GGT), total protein, albumin and globulin were significantly elevated in the HIV and malaria-positive cases compared to HIV-positive and malaria-negative controls. Significantly higher proportions of children with HIV and malaria coinfection also had elevated serum levels of ALT, ASP, GGT, total proteins, albumin and globulin compared to children without coinfection. Serum levels of Alkaline phosphatase (ALP) and Lactate dehydrogenase (LDH) were comparable in both groups.
Conclusion: Co-infection with HIV and malaria among children is generally associated with disrupted hepatic and renal function parameters.
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| first_indexed | 2024-03-07T21:57:56Z |
| format | Article |
| id | doaj.art-2f3bc7f08c1e477fbba2f667c41848bf |
| institution | Directory Open Access Journal |
| issn | 2476-8642 2536-6149 |
| language | English |
| last_indexed | 2024-03-07T21:57:56Z |
| publishDate | 2023-12-01 |
| publisher | Medical and Dental Consultants Association of Nigeria, OOUTH Sagamu |
| record_format | Article |
| series | Annals of Health Research |
| spelling | doaj.art-2f3bc7f08c1e477fbba2f667c41848bf2024-02-24T07:06:22ZengMedical and Dental Consultants Association of Nigeria, OOUTH SagamuAnnals of Health Research2476-86422536-61492023-12-019431031210.30442/ahr.0904-03-215Hepatic and Renal Functions in HIV-Positive Children with Malaria in Western KenyaMambo FAShaviya NWere TBackground: The burden of HIV and malaria co-infection lies disproportionately in the Sub-Saharan Africa region which bears most of the malaria endemic zones. While both malaria and HIV are known to dysregulate hepatic and renal functions, the combined effect of co-infection with malaria and HIV on hepatic and renal function among children remains poorly characterized. Objective: To assess liver and renal functions in HIV-malaria co-infected children in Western Kenya. Methods: A cross-sectional study was conducted among children aged 6-59 months with HIV and malaria coinfection at Kakamega County Referral Hospital, Western Kenya. A total of 138 children were enrolled. Microscopy and clinical chemistry analysers were used to diagnose malaria, and assay hepatic and renal function parameters respectively. Results: HIV positive-malaria positive cases had significantly higher serum creatinine and urea levels compared to the HIV positive-malaria negative controls. Likewise, serum levels of the alanine aminotransferase (ALT), aspartate aminotransferase (AST), gamma glutamyl transferase (GGT), total protein, albumin and globulin were significantly elevated in the HIV and malaria-positive cases compared to HIV-positive and malaria-negative controls. Significantly higher proportions of children with HIV and malaria coinfection also had elevated serum levels of ALT, ASP, GGT, total proteins, albumin and globulin compared to children without coinfection. Serum levels of Alkaline phosphatase (ALP) and Lactate dehydrogenase (LDH) were comparable in both groups. Conclusion: Co-infection with HIV and malaria among children is generally associated with disrupted hepatic and renal function parameters. https://www.annalsofhealthresearch.com/index.php/ahr/article/view/505alanine aminotransferaseaspartate aminotransferasecreatininehiv-malaria coinfectionplasmodium falciparum |
| spellingShingle | Mambo FA Shaviya N Were T Hepatic and Renal Functions in HIV-Positive Children with Malaria in Western Kenya Annals of Health Research alanine aminotransferase aspartate aminotransferase creatinine hiv-malaria coinfection plasmodium falciparum |
| title | Hepatic and Renal Functions in HIV-Positive Children with Malaria in Western Kenya |
| title_full | Hepatic and Renal Functions in HIV-Positive Children with Malaria in Western Kenya |
| title_fullStr | Hepatic and Renal Functions in HIV-Positive Children with Malaria in Western Kenya |
| title_full_unstemmed | Hepatic and Renal Functions in HIV-Positive Children with Malaria in Western Kenya |
| title_short | Hepatic and Renal Functions in HIV-Positive Children with Malaria in Western Kenya |
| title_sort | hepatic and renal functions in hiv positive children with malaria in western kenya |
| topic | alanine aminotransferase aspartate aminotransferase creatinine hiv-malaria coinfection plasmodium falciparum |
| url | https://www.annalsofhealthresearch.com/index.php/ahr/article/view/505 |
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