Fatal disseminated cytomegalovirus infection with necrotizing oophoritis in a patient with acquired immunodeficiency syndrome
Disseminated human cytomegalovirus (CMV) disease occurs mainly as a congenital infection and among immunocompromised hosts. Patients with acquired immunodeficiency syndrome (AIDS) are at increased risk for CMV infection, and the most prevalent clinical manifestation is retinitis, followed by colitis...
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| Format: | Article |
| Language: | English |
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University of São Paulo
2018-08-01
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| Series: | Autopsy and Case Reports |
| Subjects: | |
| Online Access: | http://www.revistas.usp.br/autopsy/article/view/149955 |
| _version_ | 1818918533078188032 |
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| author | Laís Braga Soares Renata Buccheri Renata Bacic Palhares Amaro Nunes Duarte-Neto |
| author_facet | Laís Braga Soares Renata Buccheri Renata Bacic Palhares Amaro Nunes Duarte-Neto |
| author_sort | Laís Braga Soares |
| collection | DOAJ |
| description | Disseminated human cytomegalovirus (CMV) disease occurs mainly as a congenital infection and among immunocompromised hosts. Patients with acquired immunodeficiency syndrome (AIDS) are at increased risk for CMV infection, and the most prevalent clinical manifestation is retinitis, followed by colitis, esophagitis, pneumonitis, and encephalitis. CMV oophoritis is poorly described in the literature with some cases reported in patients with hematological or solid malignancies, bone marrow or solid organ transplantation, immunosuppressive therapy, and advanced AIDS cases. We report the case of a 61-year-old woman with a recent diagnosis of AIDS, which was associated with a wasting syndrome. The patient presented with abdominal pain, headache, cutaneous vesicular lesions on the abdomen, anemia, lymphopenia, and hyponatremia; she died suddenly on the fourth day of hospitalization. The autopsy was performed and demonstrated disseminated CMV infection with hemorrhagic encephalitis as the immediate cause of death. Additionally, pneumonitis, extensive adrenalitis, ulcerated enteritis, focal hepatitis, and necrotizing oophoritis were found. |
| first_indexed | 2024-12-20T00:51:28Z |
| format | Article |
| id | doaj.art-2f3bfcc0c4d34637a9301007ca465442 |
| institution | Directory Open Access Journal |
| issn | 2236-1960 |
| language | English |
| last_indexed | 2024-12-20T00:51:28Z |
| publishDate | 2018-08-01 |
| publisher | University of São Paulo |
| record_format | Article |
| series | Autopsy and Case Reports |
| spelling | doaj.art-2f3bfcc0c4d34637a9301007ca4654422022-12-21T19:59:14ZengUniversity of São PauloAutopsy and Case Reports2236-19602018-08-018310.4322/acr.2018.029Fatal disseminated cytomegalovirus infection with necrotizing oophoritis in a patient with acquired immunodeficiency syndromeLaís Braga Soares0Renata Buccheri1Renata Bacic Palhares2Amaro Nunes Duarte-Neto3Emilio Ribas Institute of Infectious Diseases.Emilio Ribas Institute of Infectious Diseases.Emilio Ribas Institute of Infectious Diseases.Universidade de São Paulo, Faculty of Medicine, Department of Anatomic Pathology, Emergency Department and LIM06.Disseminated human cytomegalovirus (CMV) disease occurs mainly as a congenital infection and among immunocompromised hosts. Patients with acquired immunodeficiency syndrome (AIDS) are at increased risk for CMV infection, and the most prevalent clinical manifestation is retinitis, followed by colitis, esophagitis, pneumonitis, and encephalitis. CMV oophoritis is poorly described in the literature with some cases reported in patients with hematological or solid malignancies, bone marrow or solid organ transplantation, immunosuppressive therapy, and advanced AIDS cases. We report the case of a 61-year-old woman with a recent diagnosis of AIDS, which was associated with a wasting syndrome. The patient presented with abdominal pain, headache, cutaneous vesicular lesions on the abdomen, anemia, lymphopenia, and hyponatremia; she died suddenly on the fourth day of hospitalization. The autopsy was performed and demonstrated disseminated CMV infection with hemorrhagic encephalitis as the immediate cause of death. Additionally, pneumonitis, extensive adrenalitis, ulcerated enteritis, focal hepatitis, and necrotizing oophoritis were found.http://www.revistas.usp.br/autopsy/article/view/149955Cytomegalovirus; Acquired Immunodeficiency Syndrome; Oophoritis; Autopsy |
| spellingShingle | Laís Braga Soares Renata Buccheri Renata Bacic Palhares Amaro Nunes Duarte-Neto Fatal disseminated cytomegalovirus infection with necrotizing oophoritis in a patient with acquired immunodeficiency syndrome Autopsy and Case Reports Cytomegalovirus; Acquired Immunodeficiency Syndrome; Oophoritis; Autopsy |
| title | Fatal disseminated cytomegalovirus infection with necrotizing oophoritis in a patient with acquired immunodeficiency syndrome |
| title_full | Fatal disseminated cytomegalovirus infection with necrotizing oophoritis in a patient with acquired immunodeficiency syndrome |
| title_fullStr | Fatal disseminated cytomegalovirus infection with necrotizing oophoritis in a patient with acquired immunodeficiency syndrome |
| title_full_unstemmed | Fatal disseminated cytomegalovirus infection with necrotizing oophoritis in a patient with acquired immunodeficiency syndrome |
| title_short | Fatal disseminated cytomegalovirus infection with necrotizing oophoritis in a patient with acquired immunodeficiency syndrome |
| title_sort | fatal disseminated cytomegalovirus infection with necrotizing oophoritis in a patient with acquired immunodeficiency syndrome |
| topic | Cytomegalovirus; Acquired Immunodeficiency Syndrome; Oophoritis; Autopsy |
| url | http://www.revistas.usp.br/autopsy/article/view/149955 |
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