Taming Parasites by Tailoring Them
The next-generation gene editing based on CRISPR (clustered regularly interspaced short palindromic repeats) has been successfully implemented in a wide range of organisms including some protozoan parasites. However, application of such a versatile game-changing technology in molecular parasitology...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2017-07-01
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| Series: | Frontiers in Cellular and Infection Microbiology |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/article/10.3389/fcimb.2017.00292/full |
| _version_ | 1811237473205878784 |
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| author | Bingjian Ren Nishith Gupta |
| author_facet | Bingjian Ren Nishith Gupta |
| author_sort | Bingjian Ren |
| collection | DOAJ |
| description | The next-generation gene editing based on CRISPR (clustered regularly interspaced short palindromic repeats) has been successfully implemented in a wide range of organisms including some protozoan parasites. However, application of such a versatile game-changing technology in molecular parasitology remains fairly underexplored. Here, we briefly introduce state-of-the-art in human and mouse research and usher new directions to drive the parasitology research in the years to come. In precise, we outline contemporary ways to embolden existing apicomplexan and kinetoplastid parasite models by commissioning front-line gene-tailoring methods, and illustrate how we can break the enduring gridlock of gene manipulation in non-model parasitic protists to tackle intriguing questions that remain long unresolved otherwise. We show how a judicious solicitation of the CRISPR technology can eventually balance out the two facets of pathogen-host interplay. |
| first_indexed | 2024-04-12T12:24:01Z |
| format | Article |
| id | doaj.art-2f3c0254d89c45838cc40f34224d669b |
| institution | Directory Open Access Journal |
| issn | 2235-2988 |
| language | English |
| last_indexed | 2024-04-12T12:24:01Z |
| publishDate | 2017-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cellular and Infection Microbiology |
| spelling | doaj.art-2f3c0254d89c45838cc40f34224d669b2022-12-22T03:33:13ZengFrontiers Media S.A.Frontiers in Cellular and Infection Microbiology2235-29882017-07-01710.3389/fcimb.2017.00292276431Taming Parasites by Tailoring ThemBingjian RenNishith GuptaThe next-generation gene editing based on CRISPR (clustered regularly interspaced short palindromic repeats) has been successfully implemented in a wide range of organisms including some protozoan parasites. However, application of such a versatile game-changing technology in molecular parasitology remains fairly underexplored. Here, we briefly introduce state-of-the-art in human and mouse research and usher new directions to drive the parasitology research in the years to come. In precise, we outline contemporary ways to embolden existing apicomplexan and kinetoplastid parasite models by commissioning front-line gene-tailoring methods, and illustrate how we can break the enduring gridlock of gene manipulation in non-model parasitic protists to tackle intriguing questions that remain long unresolved otherwise. We show how a judicious solicitation of the CRISPR technology can eventually balance out the two facets of pathogen-host interplay.http://journal.frontiersin.org/article/10.3389/fcimb.2017.00292/fullparasite manipulationCRISPRgenetic engineeringprotozoan infectionsgenome editing |
| spellingShingle | Bingjian Ren Nishith Gupta Taming Parasites by Tailoring Them Frontiers in Cellular and Infection Microbiology parasite manipulation CRISPR genetic engineering protozoan infections genome editing |
| title | Taming Parasites by Tailoring Them |
| title_full | Taming Parasites by Tailoring Them |
| title_fullStr | Taming Parasites by Tailoring Them |
| title_full_unstemmed | Taming Parasites by Tailoring Them |
| title_short | Taming Parasites by Tailoring Them |
| title_sort | taming parasites by tailoring them |
| topic | parasite manipulation CRISPR genetic engineering protozoan infections genome editing |
| url | http://journal.frontiersin.org/article/10.3389/fcimb.2017.00292/full |
| work_keys_str_mv | AT bingjianren tamingparasitesbytailoringthem AT nishithgupta tamingparasitesbytailoringthem |