Novel Biomarkers of Renal Dysfunction and Congestion in Heart Failure
Heart failure is a major public health problem and, despite the constantly emerging, new, effective treatments, it remains a leading cause of morbidity and mortality. Reliable tools for early diagnosis and risk stratification are crucial in the management of HF. This explains a growing interest in t...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-05-01
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| Series: | Journal of Personalized Medicine |
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| Online Access: | https://www.mdpi.com/2075-4426/12/6/898 |
| _version_ | 1797485540201725952 |
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| author | Agata Zdanowicz Szymon Urban Barbara Ponikowska Gracjan Iwanek Robert Zymliński Piotr Ponikowski Jan Biegus |
| author_facet | Agata Zdanowicz Szymon Urban Barbara Ponikowska Gracjan Iwanek Robert Zymliński Piotr Ponikowski Jan Biegus |
| author_sort | Agata Zdanowicz |
| collection | DOAJ |
| description | Heart failure is a major public health problem and, despite the constantly emerging, new, effective treatments, it remains a leading cause of morbidity and mortality. Reliable tools for early diagnosis and risk stratification are crucial in the management of HF. This explains a growing interest in the development of new biomarkers related to various pathophysiological mechanisms of HF. In the course of this review, we focused on the markers of congestion and renal dysfunction in terms of their interference with cardiovascular homeostasis. Congestion is a hallmark feature of heart failure, contributing to symptoms, morbidity, and hospitalizations of patients with HF and has, therefore, become a therapeutic target in AHF. On the other hand, impaired renal function by altering the volume status contributes to the development and progression of HF and serves as a marker of an adverse clinical outcome. Early detection of congestion and an adequate assessment of renal status are essential for the prompt administration of patient-tailored therapy. This review provides an insight into recent advances in the field of HF biomarkers that could be potentially implemented in diagnosis and risk stratification of patients with HF. |
| first_indexed | 2024-03-09T23:20:16Z |
| format | Article |
| id | doaj.art-2f3c77dda07a4f89890ed3eafe06c2c3 |
| institution | Directory Open Access Journal |
| issn | 2075-4426 |
| language | English |
| last_indexed | 2024-03-09T23:20:16Z |
| publishDate | 2022-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Personalized Medicine |
| spelling | doaj.art-2f3c77dda07a4f89890ed3eafe06c2c32023-11-23T17:27:16ZengMDPI AGJournal of Personalized Medicine2075-44262022-05-0112689810.3390/jpm12060898Novel Biomarkers of Renal Dysfunction and Congestion in Heart FailureAgata Zdanowicz0Szymon Urban1Barbara Ponikowska2Gracjan Iwanek3Robert Zymliński4Piotr Ponikowski5Jan Biegus6Institute of Heart Diseases, Medical University, 50-556 Wroclaw, PolandInstitute of Heart Diseases, Medical University, 50-556 Wroclaw, PolandStudent Scientific Organization, Institute of Heart Diseases, Medical University, 50-556 Wroclaw, PolandInstitute of Heart Diseases, Medical University, 50-556 Wroclaw, PolandInstitute of Heart Diseases, Medical University, 50-556 Wroclaw, PolandInstitute of Heart Diseases, Medical University, 50-556 Wroclaw, PolandInstitute of Heart Diseases, Medical University, 50-556 Wroclaw, PolandHeart failure is a major public health problem and, despite the constantly emerging, new, effective treatments, it remains a leading cause of morbidity and mortality. Reliable tools for early diagnosis and risk stratification are crucial in the management of HF. This explains a growing interest in the development of new biomarkers related to various pathophysiological mechanisms of HF. In the course of this review, we focused on the markers of congestion and renal dysfunction in terms of their interference with cardiovascular homeostasis. Congestion is a hallmark feature of heart failure, contributing to symptoms, morbidity, and hospitalizations of patients with HF and has, therefore, become a therapeutic target in AHF. On the other hand, impaired renal function by altering the volume status contributes to the development and progression of HF and serves as a marker of an adverse clinical outcome. Early detection of congestion and an adequate assessment of renal status are essential for the prompt administration of patient-tailored therapy. This review provides an insight into recent advances in the field of HF biomarkers that could be potentially implemented in diagnosis and risk stratification of patients with HF.https://www.mdpi.com/2075-4426/12/6/898heart failurecongestionrenal dysfunctionbiomarker |
| spellingShingle | Agata Zdanowicz Szymon Urban Barbara Ponikowska Gracjan Iwanek Robert Zymliński Piotr Ponikowski Jan Biegus Novel Biomarkers of Renal Dysfunction and Congestion in Heart Failure Journal of Personalized Medicine heart failure congestion renal dysfunction biomarker |
| title | Novel Biomarkers of Renal Dysfunction and Congestion in Heart Failure |
| title_full | Novel Biomarkers of Renal Dysfunction and Congestion in Heart Failure |
| title_fullStr | Novel Biomarkers of Renal Dysfunction and Congestion in Heart Failure |
| title_full_unstemmed | Novel Biomarkers of Renal Dysfunction and Congestion in Heart Failure |
| title_short | Novel Biomarkers of Renal Dysfunction and Congestion in Heart Failure |
| title_sort | novel biomarkers of renal dysfunction and congestion in heart failure |
| topic | heart failure congestion renal dysfunction biomarker |
| url | https://www.mdpi.com/2075-4426/12/6/898 |
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