Time to relapse and remission of bipolar disorder: findings from a 1-year prospective study in Thailand
Thawatchai Leelahanaj,1 Ronnachai Kongsakon,2 Somrak Choovanichvong,3 Sookjaroen Tangwongchai,4 Suchat Paholpak,5 Thoranin Kongsuk,6 Manit Srisurapanont7 For the Thai Bipolar Registry Study Group 1Department of Psychiatry and Neurology, Phramongkutklao Hospital, Bangkok, Thailand; 2Department of Psy...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Dove Medical Press
2013-08-01
|
| Series: | Neuropsychiatric Disease and Treatment |
| Online Access: | http://www.dovepress.com/time-to-relapse-and-remission-of-bipolar-disorder-findings-from-a-1-ye-a14132 |
| _version_ | 1831633681067802624 |
|---|---|
| author | Leelahanaj T Kongsakon R Choovanichvong S Tangwongchai S Paholpak S Kongsuk T Srisurapanont M |
| author_facet | Leelahanaj T Kongsakon R Choovanichvong S Tangwongchai S Paholpak S Kongsuk T Srisurapanont M |
| author_sort | Leelahanaj T |
| collection | DOAJ |
| description | Thawatchai Leelahanaj,1 Ronnachai Kongsakon,2 Somrak Choovanichvong,3 Sookjaroen Tangwongchai,4 Suchat Paholpak,5 Thoranin Kongsuk,6 Manit Srisurapanont7 For the Thai Bipolar Registry Study Group 1Department of Psychiatry and Neurology, Phramongkutklao Hospital, Bangkok, Thailand; 2Department of Psychiatry, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand; 3Srithanya Hospital, Nonthaburi, Thailand; 4Department of Psychiatry, Chulalongkorn University, Bangkok, Thailand; 5Department of Psychiatry, Khon Kaen University, Khon Kaen, Thailand; 6Prasrimahabhodi Psychiatric Hospital, Ubon Ratchathani, Thailand; 7Department of Psychiatry, Chiang Mai University, Chiang Mai, Thailand Background and methods: This study aimed to determine time to relapse and remission of mood episodes in Thai patients with bipolar disorder (BD). The Thai Bipolar Disorder Registry was a multicenter, prospective, naturalistic, observational study conducted in Thailand. Participants were adult inpatients or outpatients with Diagnostic and Statistical Manual of Mental Disorders bipolar disorder. The diagnosis of bipolar disorder, current psychiatric comorbidity, mood relapse, and mood remission were determined by using the Mini International Neuropsychiatric Interview. Relapse and remission were assessed every 2 months. Results: Of 424 BD participants, 404 (95.3%) were BD I, and 258 (60.8%) were female. At entry, 260 (61.3%) had recovered, and 49 (11.6%) were recovering. During 1-year follow-up (381.7 person-years), 92 participants (21.7%) had 119 relapses or 0.31 (95% confidence interval 0.25–0.35) episodes per person-year. Among 119 relapses, 58 (48.7%), 39 (32.7%), and 21 (17.6%) of them were depressive, hypomanic, and manic episodes, respectively. Using the Kaplan–Meier method, we found that 25% of the participants relapsed in 361 days. Of the 400 participants who reached remission, 113 (28.2%) had mood relapses. Of 173 mood events accountable for remission analysis, the median time to remission was 67.5 days (72.5 days for depressive episodes versus 58.0 days for manic episodes, log rank P = 0.014). Conclusions: The 1-year relapse rate in Thai patients with BD was 21.7% or 0.31 episodes per person-year. About one-fifth of recovered patients had mood relapses within 371 days. On average, a mood episode would remit in 67.5 days. Keywords: bipolar disorder, course, outcome, relapse, remission, Thai |
| first_indexed | 2024-12-19T05:40:18Z |
| format | Article |
| id | doaj.art-2f3e201e65f042af944a98412f122fc2 |
| institution | Directory Open Access Journal |
| issn | 1176-6328 1178-2021 |
| language | English |
| last_indexed | 2024-12-19T05:40:18Z |
| publishDate | 2013-08-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Neuropsychiatric Disease and Treatment |
| spelling | doaj.art-2f3e201e65f042af944a98412f122fc22022-12-21T20:34:01ZengDove Medical PressNeuropsychiatric Disease and Treatment1176-63281178-20212013-08-012013default12491256Time to relapse and remission of bipolar disorder: findings from a 1-year prospective study in ThailandLeelahanaj TKongsakon RChoovanichvong STangwongchai SPaholpak SKongsuk TSrisurapanont MThawatchai Leelahanaj,1 Ronnachai Kongsakon,2 Somrak Choovanichvong,3 Sookjaroen Tangwongchai,4 Suchat Paholpak,5 Thoranin Kongsuk,6 Manit Srisurapanont7 For the Thai Bipolar Registry Study Group 1Department of Psychiatry and Neurology, Phramongkutklao Hospital, Bangkok, Thailand; 2Department of Psychiatry, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand; 3Srithanya Hospital, Nonthaburi, Thailand; 4Department of Psychiatry, Chulalongkorn University, Bangkok, Thailand; 5Department of Psychiatry, Khon Kaen University, Khon Kaen, Thailand; 6Prasrimahabhodi Psychiatric Hospital, Ubon Ratchathani, Thailand; 7Department of Psychiatry, Chiang Mai University, Chiang Mai, Thailand Background and methods: This study aimed to determine time to relapse and remission of mood episodes in Thai patients with bipolar disorder (BD). The Thai Bipolar Disorder Registry was a multicenter, prospective, naturalistic, observational study conducted in Thailand. Participants were adult inpatients or outpatients with Diagnostic and Statistical Manual of Mental Disorders bipolar disorder. The diagnosis of bipolar disorder, current psychiatric comorbidity, mood relapse, and mood remission were determined by using the Mini International Neuropsychiatric Interview. Relapse and remission were assessed every 2 months. Results: Of 424 BD participants, 404 (95.3%) were BD I, and 258 (60.8%) were female. At entry, 260 (61.3%) had recovered, and 49 (11.6%) were recovering. During 1-year follow-up (381.7 person-years), 92 participants (21.7%) had 119 relapses or 0.31 (95% confidence interval 0.25–0.35) episodes per person-year. Among 119 relapses, 58 (48.7%), 39 (32.7%), and 21 (17.6%) of them were depressive, hypomanic, and manic episodes, respectively. Using the Kaplan–Meier method, we found that 25% of the participants relapsed in 361 days. Of the 400 participants who reached remission, 113 (28.2%) had mood relapses. Of 173 mood events accountable for remission analysis, the median time to remission was 67.5 days (72.5 days for depressive episodes versus 58.0 days for manic episodes, log rank P = 0.014). Conclusions: The 1-year relapse rate in Thai patients with BD was 21.7% or 0.31 episodes per person-year. About one-fifth of recovered patients had mood relapses within 371 days. On average, a mood episode would remit in 67.5 days. Keywords: bipolar disorder, course, outcome, relapse, remission, Thaihttp://www.dovepress.com/time-to-relapse-and-remission-of-bipolar-disorder-findings-from-a-1-ye-a14132 |
| spellingShingle | Leelahanaj T Kongsakon R Choovanichvong S Tangwongchai S Paholpak S Kongsuk T Srisurapanont M Time to relapse and remission of bipolar disorder: findings from a 1-year prospective study in Thailand Neuropsychiatric Disease and Treatment |
| title | Time to relapse and remission of bipolar disorder: findings from a 1-year prospective study in Thailand |
| title_full | Time to relapse and remission of bipolar disorder: findings from a 1-year prospective study in Thailand |
| title_fullStr | Time to relapse and remission of bipolar disorder: findings from a 1-year prospective study in Thailand |
| title_full_unstemmed | Time to relapse and remission of bipolar disorder: findings from a 1-year prospective study in Thailand |
| title_short | Time to relapse and remission of bipolar disorder: findings from a 1-year prospective study in Thailand |
| title_sort | time to relapse and remission of bipolar disorder findings from a 1 year prospective study in thailand |
| url | http://www.dovepress.com/time-to-relapse-and-remission-of-bipolar-disorder-findings-from-a-1-ye-a14132 |
| work_keys_str_mv | AT leelahanajt timetorelapseandremissionofbipolardisorderfindingsfroma1yearprospectivestudyinthailand AT kongsakonr timetorelapseandremissionofbipolardisorderfindingsfroma1yearprospectivestudyinthailand AT choovanichvongs timetorelapseandremissionofbipolardisorderfindingsfroma1yearprospectivestudyinthailand AT tangwongchais timetorelapseandremissionofbipolardisorderfindingsfroma1yearprospectivestudyinthailand AT paholpaks timetorelapseandremissionofbipolardisorderfindingsfroma1yearprospectivestudyinthailand AT kongsukt timetorelapseandremissionofbipolardisorderfindingsfroma1yearprospectivestudyinthailand AT srisurapanontm timetorelapseandremissionofbipolardisorderfindingsfroma1yearprospectivestudyinthailand |