Mechanistic Insights into Peptide Binding and Deactivation of an Adhesion G Protein-Coupled Receptor

Mechanistic Insights into Peptide Binding and Deactivation of an Adhesion G Protein-Coupled Receptor

Adhesion G protein-coupled receptors (ADGRGs) play critical roles in the reproductive, neurological, cardiovascular, and endocrine systems. In particular, ADGRG2 plays a significant role in Ewing sarcoma cell proliferation, parathyroid cell function, and male fertility. In 2022, a cryo-EM structure...

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Bibliographic Details
Main Authors: Victor A. Adediwura, Yinglong Miao
Format: Article
Language:English
Published: MDPI AG 2023-12-01
Series:Molecules
Subjects:
adhesion G protein-coupled receptors
peptides
deactivation
Gaussian accelerated molecular dynamics (GaMD)
drug design
Online Access:https://www.mdpi.com/1420-3049/29/1/164

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