15-Hydroxyprostaglandin Dehydrogenase Is a Predictor of Stroke-Associated Pneumonia
Background and PurposeStroke is a serious fatal and disabling disease. Stroke-associated pneumonia (SAP) is the most common complication of stroke, which may further aggravate the stroke. The prevention and early prediction of SAP is a key clinical strategy. 15-hydroxyprostaglandin dehydrogenase (15...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-05-01
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| Series: | Frontiers in Neurology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fneur.2022.893624/full |
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| author | Yunfei Xu Yunfei Xu Yunfei Xu Yunfei Xu Haoduo Qiao Haoduo Qiao Haoduo Qiao Haoduo Qiao Shun Yang Lin Zhou Lin Zhou Lin Zhou Lin Zhou Yao Zhao Yao Zhao Yao Zhao Yao Zhao Qing Xu Qing Xu Qing Xu Qing Xu Shuying Miao Shuying Miao Dun Yuan Jie Zhao Ying Liu Ying Liu Ying Liu Ying Liu |
| author_facet | Yunfei Xu Yunfei Xu Yunfei Xu Yunfei Xu Haoduo Qiao Haoduo Qiao Haoduo Qiao Haoduo Qiao Shun Yang Lin Zhou Lin Zhou Lin Zhou Lin Zhou Yao Zhao Yao Zhao Yao Zhao Yao Zhao Qing Xu Qing Xu Qing Xu Qing Xu Shuying Miao Shuying Miao Dun Yuan Jie Zhao Ying Liu Ying Liu Ying Liu Ying Liu |
| author_sort | Yunfei Xu |
| collection | DOAJ |
| description | Background and PurposeStroke is a serious fatal and disabling disease. Stroke-associated pneumonia (SAP) is the most common complication of stroke, which may further aggravate the stroke. The prevention and early prediction of SAP is a key clinical strategy. 15-hydroxyprostaglandin dehydrogenase (15-PGDH) is involved in pneumonia, while its relationship with SAP has yet to be determined. Therefore, we investigated the predictive value of 15-PGDH for SAP and visualized their relationship.MethodsStroke patients were recruited and divided into SAP group and Non-SAP group. Baseline demographic and clinical data were obtained from the medical record system, blood samples were collected to detect relevant variables and 15-PGDH levels. Patient characteristics were compared with a t-test. Binary logistic regression analysis was performed to determine the predictive value of 15-PGDH for SAP. Restricted cubic splines (RCS) were performed to visualize the relationship between 15-PGDH and SAP risk. Finally, the SAP patient characteristics between the severe group and mild group were compared.Results50 patients were enrolled and divided into SAP group (n = 26) and Non-SAP group (n = 24). 15-PGDH in the SAP group was lower than that in the Non-SAP group (0.258 ± 0.275 vs. 0.784 ± 0.615, p = 0.025). Binary logistic regression analysis revealed that the lower 15-PGDH, the higher the risk of SAP (OR = 0.04, 95%CI, 0.010–0.157, p < 0.001). The RCS model showed the L-shaped relationship between 15-PGDH and SAP.ConclusionsIn stroke patients, serum 15-PGDH is a valuable biomarker for predicting SAP. There is an L-shaped relationship between the level of 15-PGDH and the risk of SAP. |
| first_indexed | 2024-12-12T19:41:40Z |
| format | Article |
| id | doaj.art-2f3f893c2dcd404988d3232b982152dc |
| institution | Directory Open Access Journal |
| issn | 1664-2295 |
| language | English |
| last_indexed | 2024-12-12T19:41:40Z |
| publishDate | 2022-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neurology |
| spelling | doaj.art-2f3f893c2dcd404988d3232b982152dc2022-12-22T00:14:12ZengFrontiers Media S.A.Frontiers in Neurology1664-22952022-05-011310.3389/fneur.2022.89362489362415-Hydroxyprostaglandin Dehydrogenase Is a Predictor of Stroke-Associated PneumoniaYunfei Xu0Yunfei Xu1Yunfei Xu2Yunfei Xu3Haoduo Qiao4Haoduo Qiao5Haoduo Qiao6Haoduo Qiao7Shun Yang8Lin Zhou9Lin Zhou10Lin Zhou11Lin Zhou12Yao Zhao13Yao Zhao14Yao Zhao15Yao Zhao16Qing Xu17Qing Xu18Qing Xu19Qing Xu20Shuying Miao21Shuying Miao22Dun Yuan23Jie Zhao24Ying Liu25Ying Liu26Ying Liu27Ying Liu28Department of Pathophysiology, Xiangya School of Medicine, Central South University, Changsha, ChinaDepartment of Neurosurgery, Xiangya Hospital, Central South University, Changsha, ChinaSepsis Translational Medicine Key Lab of Hunan Province, Central South University, Changsha, ChinaChina-Africa Research Center of Infectious Diseases, Central South University, Changsha, ChinaDepartment of Pathophysiology, Xiangya School of Medicine, Central South University, Changsha, ChinaDepartment of Neurosurgery, Xiangya Hospital, Central South University, Changsha, ChinaSepsis Translational Medicine Key Lab of Hunan Province, Central South University, Changsha, ChinaChina-Africa Research Center of Infectious Diseases, Central South University, Changsha, ChinaDepartment of Pathophysiology, Xiangya School of Medicine, Central South University, Changsha, ChinaDepartment of Pathophysiology, Xiangya School of Medicine, Central South University, Changsha, ChinaDepartment of Neurosurgery, Xiangya Hospital, Central South University, Changsha, ChinaSepsis Translational Medicine Key Lab of Hunan Province, Central South University, Changsha, ChinaChina-Africa Research Center of Infectious Diseases, Central South University, Changsha, ChinaDepartment of Pathophysiology, Xiangya School of Medicine, Central South University, Changsha, ChinaDepartment of Neurosurgery, Xiangya Hospital, Central South University, Changsha, ChinaSepsis Translational Medicine Key Lab of Hunan Province, Central South University, Changsha, ChinaChina-Africa Research Center of Infectious Diseases, Central South University, Changsha, ChinaDepartment of Pathophysiology, Xiangya School of Medicine, Central South University, Changsha, ChinaDepartment of Neurosurgery, Xiangya Hospital, Central South University, Changsha, ChinaSepsis Translational Medicine Key Lab of Hunan Province, Central South University, Changsha, ChinaChina-Africa Research Center of Infectious Diseases, Central South University, Changsha, ChinaChina-Africa Research Center of Infectious Diseases, Central South University, Changsha, ChinaDepartment of Pathology, Nanjing Drum Tower Hospital, Nanjing University Medical School, Nanjing, ChinaDepartment of Pathophysiology, Xiangya School of Medicine, Central South University, Changsha, ChinaDepartment of Pathophysiology, Xiangya School of Medicine, Central South University, Changsha, ChinaDepartment of Pathophysiology, Xiangya School of Medicine, Central South University, Changsha, ChinaDepartment of Neurosurgery, Xiangya Hospital, Central South University, Changsha, ChinaSepsis Translational Medicine Key Lab of Hunan Province, Central South University, Changsha, ChinaChina-Africa Research Center of Infectious Diseases, Central South University, Changsha, ChinaBackground and PurposeStroke is a serious fatal and disabling disease. Stroke-associated pneumonia (SAP) is the most common complication of stroke, which may further aggravate the stroke. The prevention and early prediction of SAP is a key clinical strategy. 15-hydroxyprostaglandin dehydrogenase (15-PGDH) is involved in pneumonia, while its relationship with SAP has yet to be determined. Therefore, we investigated the predictive value of 15-PGDH for SAP and visualized their relationship.MethodsStroke patients were recruited and divided into SAP group and Non-SAP group. Baseline demographic and clinical data were obtained from the medical record system, blood samples were collected to detect relevant variables and 15-PGDH levels. Patient characteristics were compared with a t-test. Binary logistic regression analysis was performed to determine the predictive value of 15-PGDH for SAP. Restricted cubic splines (RCS) were performed to visualize the relationship between 15-PGDH and SAP risk. Finally, the SAP patient characteristics between the severe group and mild group were compared.Results50 patients were enrolled and divided into SAP group (n = 26) and Non-SAP group (n = 24). 15-PGDH in the SAP group was lower than that in the Non-SAP group (0.258 ± 0.275 vs. 0.784 ± 0.615, p = 0.025). Binary logistic regression analysis revealed that the lower 15-PGDH, the higher the risk of SAP (OR = 0.04, 95%CI, 0.010–0.157, p < 0.001). The RCS model showed the L-shaped relationship between 15-PGDH and SAP.ConclusionsIn stroke patients, serum 15-PGDH is a valuable biomarker for predicting SAP. There is an L-shaped relationship between the level of 15-PGDH and the risk of SAP.https://www.frontiersin.org/articles/10.3389/fneur.2022.893624/full15-PGDHstrokepneumoniaPGE2predictor |
| spellingShingle | Yunfei Xu Yunfei Xu Yunfei Xu Yunfei Xu Haoduo Qiao Haoduo Qiao Haoduo Qiao Haoduo Qiao Shun Yang Lin Zhou Lin Zhou Lin Zhou Lin Zhou Yao Zhao Yao Zhao Yao Zhao Yao Zhao Qing Xu Qing Xu Qing Xu Qing Xu Shuying Miao Shuying Miao Dun Yuan Jie Zhao Ying Liu Ying Liu Ying Liu Ying Liu 15-Hydroxyprostaglandin Dehydrogenase Is a Predictor of Stroke-Associated Pneumonia Frontiers in Neurology 15-PGDH stroke pneumonia PGE2 predictor |
| title | 15-Hydroxyprostaglandin Dehydrogenase Is a Predictor of Stroke-Associated Pneumonia |
| title_full | 15-Hydroxyprostaglandin Dehydrogenase Is a Predictor of Stroke-Associated Pneumonia |
| title_fullStr | 15-Hydroxyprostaglandin Dehydrogenase Is a Predictor of Stroke-Associated Pneumonia |
| title_full_unstemmed | 15-Hydroxyprostaglandin Dehydrogenase Is a Predictor of Stroke-Associated Pneumonia |
| title_short | 15-Hydroxyprostaglandin Dehydrogenase Is a Predictor of Stroke-Associated Pneumonia |
| title_sort | 15 hydroxyprostaglandin dehydrogenase is a predictor of stroke associated pneumonia |
| topic | 15-PGDH stroke pneumonia PGE2 predictor |
| url | https://www.frontiersin.org/articles/10.3389/fneur.2022.893624/full |
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