Evaluation of some organic compounds on bloodstream forms of Trypanosoma cruzi
Accidental transmission of Chagas' disease to man by blood transfusion is a serious problem in Latin-America. This paper describes the testing of several synthetic, semi-synthetic, and natural compounds for their activity against blood trypomastigotes in vitro at 4-C. The compounds embody sever...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Fundação Oswaldo Cruz (FIOCRUZ)
1992-09-01
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| Series: | Memorias do Instituto Oswaldo Cruz |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02761992000300003 |
| _version_ | 1797703167019843584 |
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| author | João S. Silva S. Ferrioli-Filho M. M. Kanesiro V. F. Ferreira S. C. Santos C. N. Pinto J. L. Fonseca H. E. Mizrahy B. Gilbert M. C. F. R. Pinto F. W. Ribeiro A. V. Pinto |
| author_facet | João S. Silva S. Ferrioli-Filho M. M. Kanesiro V. F. Ferreira S. C. Santos C. N. Pinto J. L. Fonseca H. E. Mizrahy B. Gilbert M. C. F. R. Pinto F. W. Ribeiro A. V. Pinto |
| author_sort | João S. Silva |
| collection | DOAJ |
| description | Accidental transmission of Chagas' disease to man by blood transfusion is a serious problem in Latin-America. This paper describes the testing of several synthetic, semi-synthetic, and natural compounds for their activity against blood trypomastigotes in vitro at 4-C. The compounds embody several types of chemical structures: benzoquinone, naphthoquinone, anthracenequinone, phenanthrenequinone, imidazole, piperazine, quinoline, xanthene, and simple benzenic and naphthalenic derivates. Some of them are for the first time tested against Trypanosoma cruzi. The toxic effect these compounds on this parasite was done by two quite distinct sets of experiments. In one set, the compounds were added to infected blood as ethanolic solution. In this situation the most active one was a furan-1, 2-naphthoquinone, in the same range as gentian violet, a new fact to be considered in the assessment of structure-activity relationships in this class of compounds. In other set, we tentatively evaluated the biological activity of water insoluble compounds by adding them in a pure form without solvent into infected blood. In this way some appear to be very active and it was postulated that the effectiveness of such compounds must result from interactions between them and specific blood components. |
| first_indexed | 2024-03-12T05:01:35Z |
| format | Article |
| id | doaj.art-2f412987d56a4311a9ba09a5f74e670a |
| institution | Directory Open Access Journal |
| issn | 0074-0276 1678-8060 |
| language | English |
| last_indexed | 2024-03-12T05:01:35Z |
| publishDate | 1992-09-01 |
| publisher | Fundação Oswaldo Cruz (FIOCRUZ) |
| record_format | Article |
| series | Memorias do Instituto Oswaldo Cruz |
| spelling | doaj.art-2f412987d56a4311a9ba09a5f74e670a2023-09-03T09:11:22ZengFundação Oswaldo Cruz (FIOCRUZ)Memorias do Instituto Oswaldo Cruz0074-02761678-80601992-09-0187334535110.1590/S0074-02761992000300003Evaluation of some organic compounds on bloodstream forms of Trypanosoma cruziJoão S. SilvaS. Ferrioli-FilhoM. M. KanesiroV. F. FerreiraS. C. SantosC. N. PintoJ. L. FonsecaH. E. MizrahyB. GilbertM. C. F. R. PintoF. W. RibeiroA. V. PintoAccidental transmission of Chagas' disease to man by blood transfusion is a serious problem in Latin-America. This paper describes the testing of several synthetic, semi-synthetic, and natural compounds for their activity against blood trypomastigotes in vitro at 4-C. The compounds embody several types of chemical structures: benzoquinone, naphthoquinone, anthracenequinone, phenanthrenequinone, imidazole, piperazine, quinoline, xanthene, and simple benzenic and naphthalenic derivates. Some of them are for the first time tested against Trypanosoma cruzi. The toxic effect these compounds on this parasite was done by two quite distinct sets of experiments. In one set, the compounds were added to infected blood as ethanolic solution. In this situation the most active one was a furan-1, 2-naphthoquinone, in the same range as gentian violet, a new fact to be considered in the assessment of structure-activity relationships in this class of compounds. In other set, we tentatively evaluated the biological activity of water insoluble compounds by adding them in a pure form without solvent into infected blood. In this way some appear to be very active and it was postulated that the effectiveness of such compounds must result from interactions between them and specific blood components.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02761992000300003Trypanosoma cruzichemical compoundstoxicitynaphthoquinones |
| spellingShingle | João S. Silva S. Ferrioli-Filho M. M. Kanesiro V. F. Ferreira S. C. Santos C. N. Pinto J. L. Fonseca H. E. Mizrahy B. Gilbert M. C. F. R. Pinto F. W. Ribeiro A. V. Pinto Evaluation of some organic compounds on bloodstream forms of Trypanosoma cruzi Memorias do Instituto Oswaldo Cruz Trypanosoma cruzi chemical compounds toxicity naphthoquinones |
| title | Evaluation of some organic compounds on bloodstream forms of Trypanosoma cruzi |
| title_full | Evaluation of some organic compounds on bloodstream forms of Trypanosoma cruzi |
| title_fullStr | Evaluation of some organic compounds on bloodstream forms of Trypanosoma cruzi |
| title_full_unstemmed | Evaluation of some organic compounds on bloodstream forms of Trypanosoma cruzi |
| title_short | Evaluation of some organic compounds on bloodstream forms of Trypanosoma cruzi |
| title_sort | evaluation of some organic compounds on bloodstream forms of trypanosoma cruzi |
| topic | Trypanosoma cruzi chemical compounds toxicity naphthoquinones |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02761992000300003 |
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